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The effect of the surgical margins on the outcome of patients with head and neck squamous cell carcinoma: single institution experience.

Eldeeb H, Macmillan C, Elwell C, Hammod A - Cancer Biol Med (2012)

Bottom Line: Of these patients, 82 were eligible for the study.Patients were followed up for 5 years.The 5-year survival rates were 54%, 39% and 10%, respectively (P=0.002).

View Article: PubMed Central - PubMed

Affiliation: Northamptonshire Centre for Oncology, Northampton, Northamptonshire NN1 5BD, UK.

ABSTRACT

Objective: To assess the impact of close or positive surgical margins on the outcome, and to determine whether margin status influence the recurrence rate and the overall survival for patients with head and neck cancers.

Methods: Records from 1996 to 2001 of 413 patients with primary head and neck squamous cell carcinoma (SCC) treated with surgery as the first line treatment were analysed. Of these patients, 82 were eligible for the study. Patients were followed up for 5 years.

Results: Patients with margins between 5-10 mm had 50% recurrence rate (RR), those with surgical margins between 1-5 mm had RR of 59% and those with positive surgical margins had RR of 90% (P=0.004). The 5-year survival rates were 54%, 39% and 10%, respectively (P=0.002).

Conclusions: Unsatisfactory surgical margin is an independent risk factor for recurrence free survival as well as overall survival regardless of the other tumor and patient characteristics.

No MeSH data available.


Related in: MedlinePlus

The recurrence rate.
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f1: The recurrence rate.

Mentions: The recurrence rate for Group 1, 2 and 3 was 50%, 59.4%, and 90%, respectively. The median DFS in these groups was 30, 25, and 13 months, respectively. The local recurrence rate was 27%, 36%, and 53%, respectively. Regional recurrence rate in the three groups was 19%, 18%, and 26%, respectively. Distant metastasis occurred in 4%, 5% and 11% cases in the three groups, respectively. The recurrence rate in the positive margin group was significantly higher than in the other two groups (P=0.004) (Figure 1). The median survival for Group 1, 2 and 3 was 36, 26, and 20 months, respectively, and the mortality rates in these groups were 43%, 59%, and 90%, respectively (P=0.002) (Figure 2).


The effect of the surgical margins on the outcome of patients with head and neck squamous cell carcinoma: single institution experience.

Eldeeb H, Macmillan C, Elwell C, Hammod A - Cancer Biol Med (2012)

The recurrence rate.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643636&req=5

f1: The recurrence rate.
Mentions: The recurrence rate for Group 1, 2 and 3 was 50%, 59.4%, and 90%, respectively. The median DFS in these groups was 30, 25, and 13 months, respectively. The local recurrence rate was 27%, 36%, and 53%, respectively. Regional recurrence rate in the three groups was 19%, 18%, and 26%, respectively. Distant metastasis occurred in 4%, 5% and 11% cases in the three groups, respectively. The recurrence rate in the positive margin group was significantly higher than in the other two groups (P=0.004) (Figure 1). The median survival for Group 1, 2 and 3 was 36, 26, and 20 months, respectively, and the mortality rates in these groups were 43%, 59%, and 90%, respectively (P=0.002) (Figure 2).

Bottom Line: Of these patients, 82 were eligible for the study.Patients were followed up for 5 years.The 5-year survival rates were 54%, 39% and 10%, respectively (P=0.002).

View Article: PubMed Central - PubMed

Affiliation: Northamptonshire Centre for Oncology, Northampton, Northamptonshire NN1 5BD, UK.

ABSTRACT

Objective: To assess the impact of close or positive surgical margins on the outcome, and to determine whether margin status influence the recurrence rate and the overall survival for patients with head and neck cancers.

Methods: Records from 1996 to 2001 of 413 patients with primary head and neck squamous cell carcinoma (SCC) treated with surgery as the first line treatment were analysed. Of these patients, 82 were eligible for the study. Patients were followed up for 5 years.

Results: Patients with margins between 5-10 mm had 50% recurrence rate (RR), those with surgical margins between 1-5 mm had RR of 59% and those with positive surgical margins had RR of 90% (P=0.004). The 5-year survival rates were 54%, 39% and 10%, respectively (P=0.002).

Conclusions: Unsatisfactory surgical margin is an independent risk factor for recurrence free survival as well as overall survival regardless of the other tumor and patient characteristics.

No MeSH data available.


Related in: MedlinePlus