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Treatment of chronic regional pain syndrome type 1 with palmitoylethanolamide and topical ketamine cream: modulation of nonneuronal cells.

Keppel Hesselink JM, Kopsky DJ - J Pain Res (2013)

Bottom Line: Due to her swollen painful feet and left knee she is wheelchair-bound.The combination of palmitoylethanolamide and ketamine 10% cream reduced her pain by more than 50% after 1 month of treatment, and a marked reduction in swelling and skin discoloration was noticed.Furthermore, she could walk independently again and she experienced no side effects.

View Article: PubMed Central - PubMed

Affiliation: Institute for Neuropathic Pain, Bosch en Duin, The Netherlands;

ABSTRACT
Chronic regional pain syndrome (CRPS) can be intractable to treat and patients sometimes suffer for many years. Therefore, new treatment strategies are needed to alleviate symptoms in CRPS patients. This case report describes a patient suffering from intractable CRPS type 1 for 13 years. Due to her swollen painful feet and left knee she is wheelchair-bound. The combination of palmitoylethanolamide and ketamine 10% cream reduced her pain by more than 50% after 1 month of treatment, and a marked reduction in swelling and skin discoloration was noticed. Furthermore, she could walk independently again and she experienced no side effects. Thus, palmitoylethanolamide and topical ketamine could be a combination therapy option for treating CRPS patients.

No MeSH data available.


Related in: MedlinePlus

Chronic regional pain syndrome in the patient’s feet. (A) Before treatment.(B) After treatment with 10% ketamine cream and palmitoylethanolamide.
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f1-jpr-6-239: Chronic regional pain syndrome in the patient’s feet. (A) Before treatment.(B) After treatment with 10% ketamine cream and palmitoylethanolamide.

Mentions: The CRPS surged due to the fall and spread from the left foot to the knee. In November 2012, whenshe came to our Institute for Neuropathic Pain, the left knee, as well as both feet, were profoundlyswollen and the skin was red and bluish (Figure 1).The patient experienced severe impairment of functioning: walking was almost impossible and toe andfoot extensions were impaired. Thus, the patient presented herself as a severe, generalized,intractable CRPS type 1.


Treatment of chronic regional pain syndrome type 1 with palmitoylethanolamide and topical ketamine cream: modulation of nonneuronal cells.

Keppel Hesselink JM, Kopsky DJ - J Pain Res (2013)

Chronic regional pain syndrome in the patient’s feet. (A) Before treatment.(B) After treatment with 10% ketamine cream and palmitoylethanolamide.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3643547&req=5

f1-jpr-6-239: Chronic regional pain syndrome in the patient’s feet. (A) Before treatment.(B) After treatment with 10% ketamine cream and palmitoylethanolamide.
Mentions: The CRPS surged due to the fall and spread from the left foot to the knee. In November 2012, whenshe came to our Institute for Neuropathic Pain, the left knee, as well as both feet, were profoundlyswollen and the skin was red and bluish (Figure 1).The patient experienced severe impairment of functioning: walking was almost impossible and toe andfoot extensions were impaired. Thus, the patient presented herself as a severe, generalized,intractable CRPS type 1.

Bottom Line: Due to her swollen painful feet and left knee she is wheelchair-bound.The combination of palmitoylethanolamide and ketamine 10% cream reduced her pain by more than 50% after 1 month of treatment, and a marked reduction in swelling and skin discoloration was noticed.Furthermore, she could walk independently again and she experienced no side effects.

View Article: PubMed Central - PubMed

Affiliation: Institute for Neuropathic Pain, Bosch en Duin, The Netherlands;

ABSTRACT
Chronic regional pain syndrome (CRPS) can be intractable to treat and patients sometimes suffer for many years. Therefore, new treatment strategies are needed to alleviate symptoms in CRPS patients. This case report describes a patient suffering from intractable CRPS type 1 for 13 years. Due to her swollen painful feet and left knee she is wheelchair-bound. The combination of palmitoylethanolamide and ketamine 10% cream reduced her pain by more than 50% after 1 month of treatment, and a marked reduction in swelling and skin discoloration was noticed. Furthermore, she could walk independently again and she experienced no side effects. Thus, palmitoylethanolamide and topical ketamine could be a combination therapy option for treating CRPS patients.

No MeSH data available.


Related in: MedlinePlus