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Cytological diagnosis of Langerhans cell histiocytosis with cutaneous involvement.

Chandekar SA, Shah VB, Kavishwar V - J Cytol (2013)

Bottom Line: Diagnosis of LCH is often difficult and may be delayed because of its rarity and especially so if it occurs with unusual presentation.A high index of suspicion, awareness of characteristic cytological features of LCH and its differential diagnoses is necessary.This can obviate the need of biopsy and electron microscopy.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Topiwala National Medical College and B. Y. L. Nair Charitable Hospital, Mumbai, Maharashtra, India.

ABSTRACT
Langerhans cell histiocytosis (LCH) is a rare disease affecting predominantly children. The course of the disease varies, from spontaneous resolution to a progressive multisystem disorder with organ dysfunction and potential life-threatening complications. Diagnosis of LCH is often difficult and may be delayed because of its rarity and especially so if it occurs with unusual presentation. Fine needle aspiration cytology of a 4 year old male child, a case of LCH is presented with a purpose of highlighting the characteristic cytological features. A high index of suspicion, awareness of characteristic cytological features of LCH and its differential diagnoses is necessary. This can obviate the need of biopsy and electron microscopy. Immunohistochemistry if available can be performed on cytology smear and cell block.

No MeSH data available.


Related in: MedlinePlus

(a) Biopsy showing variable histiocytes with mononucleate, binucleate and multinucleate cells amidst lymphocytes and polymorphs (H and E, ×400); (b) Immunostaining with S100 showed diffuse positivity in the atypical histicytes (IHC, ×100)
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Figure 2: (a) Biopsy showing variable histiocytes with mononucleate, binucleate and multinucleate cells amidst lymphocytes and polymorphs (H and E, ×400); (b) Immunostaining with S100 showed diffuse positivity in the atypical histicytes (IHC, ×100)

Mentions: The biopsy showed sheets of atypical histiocytes with grooves with polymorphous inflammatory cells comprising of eosinophils, neutrophils, lymphocytes in background. There was no necrosis, and no mitosis [Figure 2a]. The immunohistochemistry was performed. On immunohistochemical staining, S-100 and CD1a were diffusely positive in all the atypical histiocytes [Figure 2b]. Desmin and ALK-1 were negative. The final diagnosis of Langerhans cell histiocytosis was given (Low risk).[34]


Cytological diagnosis of Langerhans cell histiocytosis with cutaneous involvement.

Chandekar SA, Shah VB, Kavishwar V - J Cytol (2013)

(a) Biopsy showing variable histiocytes with mononucleate, binucleate and multinucleate cells amidst lymphocytes and polymorphs (H and E, ×400); (b) Immunostaining with S100 showed diffuse positivity in the atypical histicytes (IHC, ×100)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643374&req=5

Figure 2: (a) Biopsy showing variable histiocytes with mononucleate, binucleate and multinucleate cells amidst lymphocytes and polymorphs (H and E, ×400); (b) Immunostaining with S100 showed diffuse positivity in the atypical histicytes (IHC, ×100)
Mentions: The biopsy showed sheets of atypical histiocytes with grooves with polymorphous inflammatory cells comprising of eosinophils, neutrophils, lymphocytes in background. There was no necrosis, and no mitosis [Figure 2a]. The immunohistochemistry was performed. On immunohistochemical staining, S-100 and CD1a were diffusely positive in all the atypical histiocytes [Figure 2b]. Desmin and ALK-1 were negative. The final diagnosis of Langerhans cell histiocytosis was given (Low risk).[34]

Bottom Line: Diagnosis of LCH is often difficult and may be delayed because of its rarity and especially so if it occurs with unusual presentation.A high index of suspicion, awareness of characteristic cytological features of LCH and its differential diagnoses is necessary.This can obviate the need of biopsy and electron microscopy.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Topiwala National Medical College and B. Y. L. Nair Charitable Hospital, Mumbai, Maharashtra, India.

ABSTRACT
Langerhans cell histiocytosis (LCH) is a rare disease affecting predominantly children. The course of the disease varies, from spontaneous resolution to a progressive multisystem disorder with organ dysfunction and potential life-threatening complications. Diagnosis of LCH is often difficult and may be delayed because of its rarity and especially so if it occurs with unusual presentation. Fine needle aspiration cytology of a 4 year old male child, a case of LCH is presented with a purpose of highlighting the characteristic cytological features. A high index of suspicion, awareness of characteristic cytological features of LCH and its differential diagnoses is necessary. This can obviate the need of biopsy and electron microscopy. Immunohistochemistry if available can be performed on cytology smear and cell block.

No MeSH data available.


Related in: MedlinePlus