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Role of cytology in fibroadenoma with clinging carcinoma.

Swetha N, Geetha Ch, Prayaga AK - J Cytol (2013)

Bottom Line: Fibroadenoma is the most common benign breast tumor in adolescent girls and young women with a peak incidence in the second and third decades of life.We describe a case of clinging type of ductal carcinoma in situ (DCIS) arising within a fibroadenoma.Clinging carcinoma, a variant of DCIS is an under recognized entity.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, India.

ABSTRACT
Fibroadenoma is the most common benign breast tumor in adolescent girls and young women with a peak incidence in the second and third decades of life. Carcinoma arising within a fibroadenoma is rare and is usually discovered incidentally. We describe a case of clinging type of ductal carcinoma in situ (DCIS) arising within a fibroadenoma. Clinging carcinoma, a variant of DCIS is an under recognized entity. Diagnosis of DCIS is made based on architecture and cytology. This case report highlights the role of fine needle aspiration cytology in the diagnosis of this entity coexisting in a fibroadenoma.

No MeSH data available.


Related in: MedlinePlus

(a) Benign glands in fibroadenoma area (H and E, ×100); (b) Dilated duct with necrotic material (H and E, ×400); (c and d) Nuclear hyperchromasia with irregular nuclear contours (H and E, ×400)
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Figure 3: (a) Benign glands in fibroadenoma area (H and E, ×100); (b) Dilated duct with necrotic material (H and E, ×400); (c and d) Nuclear hyperchromasia with irregular nuclear contours (H and E, ×400)

Mentions: Trucut biopsy of left breast lump showed features of infiltrative duct cell carcinoma. Immunohistochemistry was positive for estrogen and progesterone receptors. On the basis of the physical examination results, right breast lump was suspected as a fibroadenoma. Hence, lumpectomy was performed. The specimen grossly was a 1 × 1 cm, circumscribed tumor. Histopathology of multiple and serial sections revealed ductal structures surrounded by hyalinized stroma with focal myxoid areas. The lining of the ductal structures was bilayered. A significant number of ducts showed stratification of the lining epithelium, nuclear hyperchromasia and irregular nuclear contours, but myoepithelial lining was intact. There were no solid or cribriform areas, no stromal infiltration. The latter was confirmed by immunohistochemical staining with smooth muscle actin (SMA) and pancytokeratin (Pan CK). A diagnosis of fibroadenoma with DCIS, clinging type, was made (DCIS) [Figure 3].


Role of cytology in fibroadenoma with clinging carcinoma.

Swetha N, Geetha Ch, Prayaga AK - J Cytol (2013)

(a) Benign glands in fibroadenoma area (H and E, ×100); (b) Dilated duct with necrotic material (H and E, ×400); (c and d) Nuclear hyperchromasia with irregular nuclear contours (H and E, ×400)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643372&req=5

Figure 3: (a) Benign glands in fibroadenoma area (H and E, ×100); (b) Dilated duct with necrotic material (H and E, ×400); (c and d) Nuclear hyperchromasia with irregular nuclear contours (H and E, ×400)
Mentions: Trucut biopsy of left breast lump showed features of infiltrative duct cell carcinoma. Immunohistochemistry was positive for estrogen and progesterone receptors. On the basis of the physical examination results, right breast lump was suspected as a fibroadenoma. Hence, lumpectomy was performed. The specimen grossly was a 1 × 1 cm, circumscribed tumor. Histopathology of multiple and serial sections revealed ductal structures surrounded by hyalinized stroma with focal myxoid areas. The lining of the ductal structures was bilayered. A significant number of ducts showed stratification of the lining epithelium, nuclear hyperchromasia and irregular nuclear contours, but myoepithelial lining was intact. There were no solid or cribriform areas, no stromal infiltration. The latter was confirmed by immunohistochemical staining with smooth muscle actin (SMA) and pancytokeratin (Pan CK). A diagnosis of fibroadenoma with DCIS, clinging type, was made (DCIS) [Figure 3].

Bottom Line: Fibroadenoma is the most common benign breast tumor in adolescent girls and young women with a peak incidence in the second and third decades of life.We describe a case of clinging type of ductal carcinoma in situ (DCIS) arising within a fibroadenoma.Clinging carcinoma, a variant of DCIS is an under recognized entity.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, India.

ABSTRACT
Fibroadenoma is the most common benign breast tumor in adolescent girls and young women with a peak incidence in the second and third decades of life. Carcinoma arising within a fibroadenoma is rare and is usually discovered incidentally. We describe a case of clinging type of ductal carcinoma in situ (DCIS) arising within a fibroadenoma. Clinging carcinoma, a variant of DCIS is an under recognized entity. Diagnosis of DCIS is made based on architecture and cytology. This case report highlights the role of fine needle aspiration cytology in the diagnosis of this entity coexisting in a fibroadenoma.

No MeSH data available.


Related in: MedlinePlus