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Peritoneal washing cytology in an adult granulosa cell tumor: A case report and review of literature.

Atilgan AO, Tepeoglu M, Ozen O, Bilezikçi B - J Cytol (2013)

Bottom Line: Adult-type granulosa cell tumors (AGCT) account for 1-2% of all ovarian tumors and 95% of granulosa cell tumors.Patients with positive peritoneal washing cytology must be followed up for pelvic recurrence and metastasis.Here, we describe a case of AGCT with the emphasis on cytologic features observed in specimens obtained from peritoneal washing fluid.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Başkent University, School of Medicine, Bahçelievler, Turkey.

ABSTRACT
Adult-type granulosa cell tumors (AGCT) account for 1-2% of all ovarian tumors and 95% of granulosa cell tumors. In AGCT, at the time of peritoneal washing, tumor cells are rarely seen to exfoliate and FIGO stage is raised from IA/IB or IIA/IIB to stage IC or IIC despite the absence of a gross intraepithelial tumor. Patients with positive peritoneal washing cytology must be followed up for pelvic recurrence and metastasis. A more sensitive cytologic evaluation, histopathologic correlation and immunohistochemical staining can advance our practice. Here, we describe a case of AGCT with the emphasis on cytologic features observed in specimens obtained from peritoneal washing fluid.

No MeSH data available.


Related in: MedlinePlus

Photomicrograph of positive immunohistochemical stain for inhibin. (IHC, ×40)
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Figure 4: Photomicrograph of positive immunohistochemical stain for inhibin. (IHC, ×40)

Mentions: Gross examination of the right ovarian mass showed a tan and solid tumor with small cystic structures. Microscopically, the tumor was composed of granulosa cells arranged in the trabecular and microfollicular pattern [Figure 3]. Mild cytological atypia and 6 mitosis per 10 high power field (×400) were observed in the tumor, while there was no necrosis. Immunohistochemical stains exhibited that the tumor cells were strongly and diffusely cytoplasmic positive for inhibin and negative for epithelial membrane antigen (EMA) [Figure 4]. Both the cytological and histological findings were consistent with the diagnosis of AGCT. The histological examination of the implants in the peritoneal cavity and omentum also confirmed the diagnosis of AGCT.


Peritoneal washing cytology in an adult granulosa cell tumor: A case report and review of literature.

Atilgan AO, Tepeoglu M, Ozen O, Bilezikçi B - J Cytol (2013)

Photomicrograph of positive immunohistochemical stain for inhibin. (IHC, ×40)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643371&req=5

Figure 4: Photomicrograph of positive immunohistochemical stain for inhibin. (IHC, ×40)
Mentions: Gross examination of the right ovarian mass showed a tan and solid tumor with small cystic structures. Microscopically, the tumor was composed of granulosa cells arranged in the trabecular and microfollicular pattern [Figure 3]. Mild cytological atypia and 6 mitosis per 10 high power field (×400) were observed in the tumor, while there was no necrosis. Immunohistochemical stains exhibited that the tumor cells were strongly and diffusely cytoplasmic positive for inhibin and negative for epithelial membrane antigen (EMA) [Figure 4]. Both the cytological and histological findings were consistent with the diagnosis of AGCT. The histological examination of the implants in the peritoneal cavity and omentum also confirmed the diagnosis of AGCT.

Bottom Line: Adult-type granulosa cell tumors (AGCT) account for 1-2% of all ovarian tumors and 95% of granulosa cell tumors.Patients with positive peritoneal washing cytology must be followed up for pelvic recurrence and metastasis.Here, we describe a case of AGCT with the emphasis on cytologic features observed in specimens obtained from peritoneal washing fluid.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Başkent University, School of Medicine, Bahçelievler, Turkey.

ABSTRACT
Adult-type granulosa cell tumors (AGCT) account for 1-2% of all ovarian tumors and 95% of granulosa cell tumors. In AGCT, at the time of peritoneal washing, tumor cells are rarely seen to exfoliate and FIGO stage is raised from IA/IB or IIA/IIB to stage IC or IIC despite the absence of a gross intraepithelial tumor. Patients with positive peritoneal washing cytology must be followed up for pelvic recurrence and metastasis. A more sensitive cytologic evaluation, histopathologic correlation and immunohistochemical staining can advance our practice. Here, we describe a case of AGCT with the emphasis on cytologic features observed in specimens obtained from peritoneal washing fluid.

No MeSH data available.


Related in: MedlinePlus