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Peritoneal washing cytology in an adult granulosa cell tumor: A case report and review of literature.

Atilgan AO, Tepeoglu M, Ozen O, Bilezikçi B - J Cytol (2013)

Bottom Line: Adult-type granulosa cell tumors (AGCT) account for 1-2% of all ovarian tumors and 95% of granulosa cell tumors.Patients with positive peritoneal washing cytology must be followed up for pelvic recurrence and metastasis.Here, we describe a case of AGCT with the emphasis on cytologic features observed in specimens obtained from peritoneal washing fluid.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Başkent University, School of Medicine, Bahçelievler, Turkey.

ABSTRACT
Adult-type granulosa cell tumors (AGCT) account for 1-2% of all ovarian tumors and 95% of granulosa cell tumors. In AGCT, at the time of peritoneal washing, tumor cells are rarely seen to exfoliate and FIGO stage is raised from IA/IB or IIA/IIB to stage IC or IIC despite the absence of a gross intraepithelial tumor. Patients with positive peritoneal washing cytology must be followed up for pelvic recurrence and metastasis. A more sensitive cytologic evaluation, histopathologic correlation and immunohistochemical staining can advance our practice. Here, we describe a case of AGCT with the emphasis on cytologic features observed in specimens obtained from peritoneal washing fluid.

No MeSH data available.


Related in: MedlinePlus

Photomicrograph of cytology specimen. Tumor cells surrounding eosinophilic hyaline globules resembling call-Exner bodies. (H and E, ×100)
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Figure 2: Photomicrograph of cytology specimen. Tumor cells surrounding eosinophilic hyaline globules resembling call-Exner bodies. (H and E, ×100)

Mentions: Peritoneal washing fluid was prepared using conventional methods. Cytology was hypercellular with both large and small overlapping cell clusters [Figure 1]. Tumor cells were round to oval, with hyperchromatic nuclei containing granular chromatin. Micronucleoli and cytoplasmic vacuoles were not observed. Characteristic Call-Exner bodies showing microfollicular structures with amorphous material and rare, coffee-bean-like nuclear grooves were seen [Figure 2]. Theca cells were not observed.


Peritoneal washing cytology in an adult granulosa cell tumor: A case report and review of literature.

Atilgan AO, Tepeoglu M, Ozen O, Bilezikçi B - J Cytol (2013)

Photomicrograph of cytology specimen. Tumor cells surrounding eosinophilic hyaline globules resembling call-Exner bodies. (H and E, ×100)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643371&req=5

Figure 2: Photomicrograph of cytology specimen. Tumor cells surrounding eosinophilic hyaline globules resembling call-Exner bodies. (H and E, ×100)
Mentions: Peritoneal washing fluid was prepared using conventional methods. Cytology was hypercellular with both large and small overlapping cell clusters [Figure 1]. Tumor cells were round to oval, with hyperchromatic nuclei containing granular chromatin. Micronucleoli and cytoplasmic vacuoles were not observed. Characteristic Call-Exner bodies showing microfollicular structures with amorphous material and rare, coffee-bean-like nuclear grooves were seen [Figure 2]. Theca cells were not observed.

Bottom Line: Adult-type granulosa cell tumors (AGCT) account for 1-2% of all ovarian tumors and 95% of granulosa cell tumors.Patients with positive peritoneal washing cytology must be followed up for pelvic recurrence and metastasis.Here, we describe a case of AGCT with the emphasis on cytologic features observed in specimens obtained from peritoneal washing fluid.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Başkent University, School of Medicine, Bahçelievler, Turkey.

ABSTRACT
Adult-type granulosa cell tumors (AGCT) account for 1-2% of all ovarian tumors and 95% of granulosa cell tumors. In AGCT, at the time of peritoneal washing, tumor cells are rarely seen to exfoliate and FIGO stage is raised from IA/IB or IIA/IIB to stage IC or IIC despite the absence of a gross intraepithelial tumor. Patients with positive peritoneal washing cytology must be followed up for pelvic recurrence and metastasis. A more sensitive cytologic evaluation, histopathologic correlation and immunohistochemical staining can advance our practice. Here, we describe a case of AGCT with the emphasis on cytologic features observed in specimens obtained from peritoneal washing fluid.

No MeSH data available.


Related in: MedlinePlus