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Cytomorphology of pleomorphic fibroma of skin: A diagnostic enigma.

Yadav Y, Kushwaha R, Sharma U, Gupta K - J Cytol (2013)

Bottom Line: Pleomorphic fibroma (PF) is a benign, polypoid, or dome-shaped cutaneous neoplasm with cytologically atypical fibrohistiocytic cells.This lesion is benign despite the presence of pleomorphic or bizarre cells.We review the differential diagnosis of PF with other mesenchymal tumors.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Integral Institute of Medical Sciences and Research, Lucknow, India.

ABSTRACT
Pleomorphic fibroma (PF) is a benign, polypoid, or dome-shaped cutaneous neoplasm with cytologically atypical fibrohistiocytic cells. We describe the cytomorphological features of PF retrospectively with histopathological diagnosis in a 38-year-old male who presented with 3 × 1.5 cm swelling in the soft tissues of the thigh for 6 months. This lesion is benign despite the presence of pleomorphic or bizarre cells. We review the differential diagnosis of PF with other mesenchymal tumors. To the best of our knowledge, cytomorphological features on fine needle aspiration cytology of this tumor are not yet documented in literature.

No MeSH data available.


Related in: MedlinePlus

Section showing pleomorphic cells scattered between the collagen bundles (H and E, ×200)
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Figure 2: Section showing pleomorphic cells scattered between the collagen bundles (H and E, ×200)

Mentions: On gross examination, the mass was well circumscribed measuring 3 × 1.5 cm. The cut section was solid, grayish-white, and fibrous. Routine processing and hematoxylin and eosin staining were done. Microscopically, tumor showed thick bundle of haphazardly arranged collagen in the dermis. Spindle- and irregularly shaped stellate or multinucleate cells were scattered between the collagen bundles. These cells were markedly atypical showing scant cytoplasm and large, pleomorphic, enlarged hyperchromatic nuclei with small nucleoli [Figure 2]. No mitosis or necrosis was evident in multiple sections examined. Based on these features, diagnosis of PF was made.


Cytomorphology of pleomorphic fibroma of skin: A diagnostic enigma.

Yadav Y, Kushwaha R, Sharma U, Gupta K - J Cytol (2013)

Section showing pleomorphic cells scattered between the collagen bundles (H and E, ×200)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643370&req=5

Figure 2: Section showing pleomorphic cells scattered between the collagen bundles (H and E, ×200)
Mentions: On gross examination, the mass was well circumscribed measuring 3 × 1.5 cm. The cut section was solid, grayish-white, and fibrous. Routine processing and hematoxylin and eosin staining were done. Microscopically, tumor showed thick bundle of haphazardly arranged collagen in the dermis. Spindle- and irregularly shaped stellate or multinucleate cells were scattered between the collagen bundles. These cells were markedly atypical showing scant cytoplasm and large, pleomorphic, enlarged hyperchromatic nuclei with small nucleoli [Figure 2]. No mitosis or necrosis was evident in multiple sections examined. Based on these features, diagnosis of PF was made.

Bottom Line: Pleomorphic fibroma (PF) is a benign, polypoid, or dome-shaped cutaneous neoplasm with cytologically atypical fibrohistiocytic cells.This lesion is benign despite the presence of pleomorphic or bizarre cells.We review the differential diagnosis of PF with other mesenchymal tumors.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Integral Institute of Medical Sciences and Research, Lucknow, India.

ABSTRACT
Pleomorphic fibroma (PF) is a benign, polypoid, or dome-shaped cutaneous neoplasm with cytologically atypical fibrohistiocytic cells. We describe the cytomorphological features of PF retrospectively with histopathological diagnosis in a 38-year-old male who presented with 3 × 1.5 cm swelling in the soft tissues of the thigh for 6 months. This lesion is benign despite the presence of pleomorphic or bizarre cells. We review the differential diagnosis of PF with other mesenchymal tumors. To the best of our knowledge, cytomorphological features on fine needle aspiration cytology of this tumor are not yet documented in literature.

No MeSH data available.


Related in: MedlinePlus