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Intravascular papillary endothelial hyperplasia diagnosed by fine needle aspiration: Report of a case and cytology literature review.

Kovalovsky A, Reynders A, Khurana K - J Cytol (2013)

Bottom Line: The endothelial cells were positive for CD34 and factor VIII, supporting the cytological diagnosis of IVPEH.Surgical excision confirmed the diagnosis.To the best of our knowledge, this is the first reported case of IVPEH diagnosed by preoperative FNA.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, State University of New York, USA.

ABSTRACT
Intravascular papillary endothelial hyperplasia (IVPEH) is an unusual form of intravascular endothelial proliferation. Fine needle aspiration (FNA) diagnosis of IVPEH is quite challenging and only rare reports of the cytopathological features of this entity have been published. We report a case of a 55-year-old female patient who presented with a mass on her left jaw. FNA of the mass revealed pleomorphic polygonal and spindle cells. A preliminary (onsite) cytological diagnosis of suspicious for malignancy was rendered. Subsequent cell block showed delicate papillae composed of attenuated endothelial cells overlying collagenized cores. The endothelial cells were positive for CD34 and factor VIII, supporting the cytological diagnosis of IVPEH. Surgical excision confirmed the diagnosis. To the best of our knowledge, this is the first reported case of IVPEH diagnosed by preoperative FNA.

No MeSH data available.


Related in: MedlinePlus

Histological section of resected tumor showing numerous areas of endothelial ingrowths and delicate papillae with hyalinized cores covered by attenuated endothelial cells (H and E, ×200)
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Figure 6: Histological section of resected tumor showing numerous areas of endothelial ingrowths and delicate papillae with hyalinized cores covered by attenuated endothelial cells (H and E, ×200)

Mentions: The resected specimen measured 1.5 × 1.3 × 0.7 cm and revealed a hemorrhagic cut surface. The sections showed intravascular lesion with a blood clot. The characteristic features of IVPEH with numerous areas of endothelial ingrowths and delicate papillae with hyalinized cores covered by attenuated endothelial cells as noted in cell block sections were seen [Figure 6]. Loosely arranged bands of fibrous tissue were identified at the periphery of the specimen. No mitotic activity was noted. A CD34 immunohistochemical stain was performed, and it outlined the papillary structures, as well as some of the fibrous tissue at the periphery of the specimen.


Intravascular papillary endothelial hyperplasia diagnosed by fine needle aspiration: Report of a case and cytology literature review.

Kovalovsky A, Reynders A, Khurana K - J Cytol (2013)

Histological section of resected tumor showing numerous areas of endothelial ingrowths and delicate papillae with hyalinized cores covered by attenuated endothelial cells (H and E, ×200)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643361&req=5

Figure 6: Histological section of resected tumor showing numerous areas of endothelial ingrowths and delicate papillae with hyalinized cores covered by attenuated endothelial cells (H and E, ×200)
Mentions: The resected specimen measured 1.5 × 1.3 × 0.7 cm and revealed a hemorrhagic cut surface. The sections showed intravascular lesion with a blood clot. The characteristic features of IVPEH with numerous areas of endothelial ingrowths and delicate papillae with hyalinized cores covered by attenuated endothelial cells as noted in cell block sections were seen [Figure 6]. Loosely arranged bands of fibrous tissue were identified at the periphery of the specimen. No mitotic activity was noted. A CD34 immunohistochemical stain was performed, and it outlined the papillary structures, as well as some of the fibrous tissue at the periphery of the specimen.

Bottom Line: The endothelial cells were positive for CD34 and factor VIII, supporting the cytological diagnosis of IVPEH.Surgical excision confirmed the diagnosis.To the best of our knowledge, this is the first reported case of IVPEH diagnosed by preoperative FNA.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, State University of New York, USA.

ABSTRACT
Intravascular papillary endothelial hyperplasia (IVPEH) is an unusual form of intravascular endothelial proliferation. Fine needle aspiration (FNA) diagnosis of IVPEH is quite challenging and only rare reports of the cytopathological features of this entity have been published. We report a case of a 55-year-old female patient who presented with a mass on her left jaw. FNA of the mass revealed pleomorphic polygonal and spindle cells. A preliminary (onsite) cytological diagnosis of suspicious for malignancy was rendered. Subsequent cell block showed delicate papillae composed of attenuated endothelial cells overlying collagenized cores. The endothelial cells were positive for CD34 and factor VIII, supporting the cytological diagnosis of IVPEH. Surgical excision confirmed the diagnosis. To the best of our knowledge, this is the first reported case of IVPEH diagnosed by preoperative FNA.

No MeSH data available.


Related in: MedlinePlus