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Image-guided fine-needle aspiration of retroperitoneal masses: The role of the cytopathologist.

Mehdi G, Maheshwari V, Afzal S, Ansari HA, Ahmad I - J Cytol (2013)

Bottom Line: The results were analyzed to determine sensitivity, specificity, and diagnostic efficacy of cytopathological diagnosis using image-guided FNA techniques.No major complications were encountered.In areas where advanced tests are not available, the cytotechnologist and cytopathologist have a very important role to play in ensuring accurate diagnoses.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

ABSTRACT

Background: Retroperitoneal tumors constitute a difficult diagnostic category as they are not easily accessible. The advent of image-guided fine-needle aspiration (FNA) has resolved this problem significantly.

Aims: We present a short study based on guided aspiration of retroperitoneal tumors, in which we have tried to assess the role of image-guided fine-needle aspiration cytology as a tool for pre-operative diagnosis.

Materials and methods: The study was conducted on patients diagnosed with retroperitoneal masses. FNA was performed under image guidance with the help of ultrasonography and/or computed tomography; smears were prepared and meticulously screened according to a fixed protocol. The results were analyzed to determine sensitivity, specificity, and diagnostic efficacy of cytopathological diagnosis using image-guided FNA techniques.

Results: We assessed 38 patients with retroperitoneal masses. In all cases, adequate cellular material was obtained. No major complications were encountered. Statistical analysis was carried out in 35 cases; sensitivity, specificity, and diagnostic accuracy were 100% in these cases.

Conclusion: FNA under image guidance should be considered a first-line diagnostic approach for retroperitoneal and other abdominal tumors, although caution should be exercised in case selection. In areas where advanced tests are not available, the cytotechnologist and cytopathologist have a very important role to play in ensuring accurate diagnoses.

No MeSH data available.


Related in: MedlinePlus

(a) Neuroblastoma: Richly cellular smear composed of small, round, blue cells, with nuclear molding, rosette formations, and fibrillary neuropil (H and E, ×250); (b) Chordoma: Large physaliphorous cells with abundant, vacuolated cytoplasm and small nuclei in a myxoid background (↑) (H and E, ×250)
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Figure 4: (a) Neuroblastoma: Richly cellular smear composed of small, round, blue cells, with nuclear molding, rosette formations, and fibrillary neuropil (H and E, ×250); (b) Chordoma: Large physaliphorous cells with abundant, vacuolated cytoplasm and small nuclei in a myxoid background (↑) (H and E, ×250)

Mentions: Numerous, individually scattered small cells along with groups showing prominent nuclear molding and rosette formations were seen in smears of neuroblastoma. The cells had high nuclear-cytoplasmic ratio with oval or irregular hyperchromatic nuclei, prominent nucleoli, and negligible amount of cytoplasm [Figure 4a]. Fine fibrillary material, the neuropil, could be seen in the center of the rosettes as well as scattered freely in the background.


Image-guided fine-needle aspiration of retroperitoneal masses: The role of the cytopathologist.

Mehdi G, Maheshwari V, Afzal S, Ansari HA, Ahmad I - J Cytol (2013)

(a) Neuroblastoma: Richly cellular smear composed of small, round, blue cells, with nuclear molding, rosette formations, and fibrillary neuropil (H and E, ×250); (b) Chordoma: Large physaliphorous cells with abundant, vacuolated cytoplasm and small nuclei in a myxoid background (↑) (H and E, ×250)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643360&req=5

Figure 4: (a) Neuroblastoma: Richly cellular smear composed of small, round, blue cells, with nuclear molding, rosette formations, and fibrillary neuropil (H and E, ×250); (b) Chordoma: Large physaliphorous cells with abundant, vacuolated cytoplasm and small nuclei in a myxoid background (↑) (H and E, ×250)
Mentions: Numerous, individually scattered small cells along with groups showing prominent nuclear molding and rosette formations were seen in smears of neuroblastoma. The cells had high nuclear-cytoplasmic ratio with oval or irregular hyperchromatic nuclei, prominent nucleoli, and negligible amount of cytoplasm [Figure 4a]. Fine fibrillary material, the neuropil, could be seen in the center of the rosettes as well as scattered freely in the background.

Bottom Line: The results were analyzed to determine sensitivity, specificity, and diagnostic efficacy of cytopathological diagnosis using image-guided FNA techniques.No major complications were encountered.In areas where advanced tests are not available, the cytotechnologist and cytopathologist have a very important role to play in ensuring accurate diagnoses.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

ABSTRACT

Background: Retroperitoneal tumors constitute a difficult diagnostic category as they are not easily accessible. The advent of image-guided fine-needle aspiration (FNA) has resolved this problem significantly.

Aims: We present a short study based on guided aspiration of retroperitoneal tumors, in which we have tried to assess the role of image-guided fine-needle aspiration cytology as a tool for pre-operative diagnosis.

Materials and methods: The study was conducted on patients diagnosed with retroperitoneal masses. FNA was performed under image guidance with the help of ultrasonography and/or computed tomography; smears were prepared and meticulously screened according to a fixed protocol. The results were analyzed to determine sensitivity, specificity, and diagnostic efficacy of cytopathological diagnosis using image-guided FNA techniques.

Results: We assessed 38 patients with retroperitoneal masses. In all cases, adequate cellular material was obtained. No major complications were encountered. Statistical analysis was carried out in 35 cases; sensitivity, specificity, and diagnostic accuracy were 100% in these cases.

Conclusion: FNA under image guidance should be considered a first-line diagnostic approach for retroperitoneal and other abdominal tumors, although caution should be exercised in case selection. In areas where advanced tests are not available, the cytotechnologist and cytopathologist have a very important role to play in ensuring accurate diagnoses.

No MeSH data available.


Related in: MedlinePlus