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Image-guided fine-needle aspiration of retroperitoneal masses: The role of the cytopathologist.

Mehdi G, Maheshwari V, Afzal S, Ansari HA, Ahmad I - J Cytol (2013)

Bottom Line: The results were analyzed to determine sensitivity, specificity, and diagnostic efficacy of cytopathological diagnosis using image-guided FNA techniques.No major complications were encountered.In areas where advanced tests are not available, the cytotechnologist and cytopathologist have a very important role to play in ensuring accurate diagnoses.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

ABSTRACT

Background: Retroperitoneal tumors constitute a difficult diagnostic category as they are not easily accessible. The advent of image-guided fine-needle aspiration (FNA) has resolved this problem significantly.

Aims: We present a short study based on guided aspiration of retroperitoneal tumors, in which we have tried to assess the role of image-guided fine-needle aspiration cytology as a tool for pre-operative diagnosis.

Materials and methods: The study was conducted on patients diagnosed with retroperitoneal masses. FNA was performed under image guidance with the help of ultrasonography and/or computed tomography; smears were prepared and meticulously screened according to a fixed protocol. The results were analyzed to determine sensitivity, specificity, and diagnostic efficacy of cytopathological diagnosis using image-guided FNA techniques.

Results: We assessed 38 patients with retroperitoneal masses. In all cases, adequate cellular material was obtained. No major complications were encountered. Statistical analysis was carried out in 35 cases; sensitivity, specificity, and diagnostic accuracy were 100% in these cases.

Conclusion: FNA under image guidance should be considered a first-line diagnostic approach for retroperitoneal and other abdominal tumors, although caution should be exercised in case selection. In areas where advanced tests are not available, the cytotechnologist and cytopathologist have a very important role to play in ensuring accurate diagnoses.

No MeSH data available.


Related in: MedlinePlus

(a) Wilm's tumor: Spindle-shaped mesenchymal cells along with small, round, hyperchromatic blastemal cells (Pap, ×250); (b) Adenocarcinoma pancreas: Tumor cells with hyperchromatic nuclei arranged in acinar pattern (H and E, ×125); (c) Lipoma: Adipocytes with clear cytoplasm and compressed nuclei (H and E, ×250); (d) Liposarcoma: Lipoblasts with vacuolated cytoplasm and scalloped, hyperchromatic nuclei (↑) (H and E, ×250)
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Figure 3: (a) Wilm's tumor: Spindle-shaped mesenchymal cells along with small, round, hyperchromatic blastemal cells (Pap, ×250); (b) Adenocarcinoma pancreas: Tumor cells with hyperchromatic nuclei arranged in acinar pattern (H and E, ×125); (c) Lipoma: Adipocytes with clear cytoplasm and compressed nuclei (H and E, ×250); (d) Liposarcoma: Lipoblasts with vacuolated cytoplasm and scalloped, hyperchromatic nuclei (↑) (H and E, ×250)

Mentions: Aspirates from three cases of Wilms' tumor (pediatric age group) showed numerous undifferentiated small cells arranged singly or in tight clusters. Some rosette-like structures were also noticed. The cells had scant blue cytoplasm, with small, round or ovoid hyperchromatic nuclei and multiple small nucleoli. Mesenchymal differentiation in the form of spindle cells was also appreciated [Figure 3a]. Histopathology sections demonstrated the presence of the three major components of the tumor, undifferentiated blastema, mesenchymal, and epithelial tissue forming abortive glomeruli and tubules.


Image-guided fine-needle aspiration of retroperitoneal masses: The role of the cytopathologist.

Mehdi G, Maheshwari V, Afzal S, Ansari HA, Ahmad I - J Cytol (2013)

(a) Wilm's tumor: Spindle-shaped mesenchymal cells along with small, round, hyperchromatic blastemal cells (Pap, ×250); (b) Adenocarcinoma pancreas: Tumor cells with hyperchromatic nuclei arranged in acinar pattern (H and E, ×125); (c) Lipoma: Adipocytes with clear cytoplasm and compressed nuclei (H and E, ×250); (d) Liposarcoma: Lipoblasts with vacuolated cytoplasm and scalloped, hyperchromatic nuclei (↑) (H and E, ×250)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643360&req=5

Figure 3: (a) Wilm's tumor: Spindle-shaped mesenchymal cells along with small, round, hyperchromatic blastemal cells (Pap, ×250); (b) Adenocarcinoma pancreas: Tumor cells with hyperchromatic nuclei arranged in acinar pattern (H and E, ×125); (c) Lipoma: Adipocytes with clear cytoplasm and compressed nuclei (H and E, ×250); (d) Liposarcoma: Lipoblasts with vacuolated cytoplasm and scalloped, hyperchromatic nuclei (↑) (H and E, ×250)
Mentions: Aspirates from three cases of Wilms' tumor (pediatric age group) showed numerous undifferentiated small cells arranged singly or in tight clusters. Some rosette-like structures were also noticed. The cells had scant blue cytoplasm, with small, round or ovoid hyperchromatic nuclei and multiple small nucleoli. Mesenchymal differentiation in the form of spindle cells was also appreciated [Figure 3a]. Histopathology sections demonstrated the presence of the three major components of the tumor, undifferentiated blastema, mesenchymal, and epithelial tissue forming abortive glomeruli and tubules.

Bottom Line: The results were analyzed to determine sensitivity, specificity, and diagnostic efficacy of cytopathological diagnosis using image-guided FNA techniques.No major complications were encountered.In areas where advanced tests are not available, the cytotechnologist and cytopathologist have a very important role to play in ensuring accurate diagnoses.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

ABSTRACT

Background: Retroperitoneal tumors constitute a difficult diagnostic category as they are not easily accessible. The advent of image-guided fine-needle aspiration (FNA) has resolved this problem significantly.

Aims: We present a short study based on guided aspiration of retroperitoneal tumors, in which we have tried to assess the role of image-guided fine-needle aspiration cytology as a tool for pre-operative diagnosis.

Materials and methods: The study was conducted on patients diagnosed with retroperitoneal masses. FNA was performed under image guidance with the help of ultrasonography and/or computed tomography; smears were prepared and meticulously screened according to a fixed protocol. The results were analyzed to determine sensitivity, specificity, and diagnostic efficacy of cytopathological diagnosis using image-guided FNA techniques.

Results: We assessed 38 patients with retroperitoneal masses. In all cases, adequate cellular material was obtained. No major complications were encountered. Statistical analysis was carried out in 35 cases; sensitivity, specificity, and diagnostic accuracy were 100% in these cases.

Conclusion: FNA under image guidance should be considered a first-line diagnostic approach for retroperitoneal and other abdominal tumors, although caution should be exercised in case selection. In areas where advanced tests are not available, the cytotechnologist and cytopathologist have a very important role to play in ensuring accurate diagnoses.

No MeSH data available.


Related in: MedlinePlus