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Image-guided fine-needle aspiration of retroperitoneal masses: The role of the cytopathologist.

Mehdi G, Maheshwari V, Afzal S, Ansari HA, Ahmad I - J Cytol (2013)

Bottom Line: The results were analyzed to determine sensitivity, specificity, and diagnostic efficacy of cytopathological diagnosis using image-guided FNA techniques.No major complications were encountered.In areas where advanced tests are not available, the cytotechnologist and cytopathologist have a very important role to play in ensuring accurate diagnoses.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

ABSTRACT

Background: Retroperitoneal tumors constitute a difficult diagnostic category as they are not easily accessible. The advent of image-guided fine-needle aspiration (FNA) has resolved this problem significantly.

Aims: We present a short study based on guided aspiration of retroperitoneal tumors, in which we have tried to assess the role of image-guided fine-needle aspiration cytology as a tool for pre-operative diagnosis.

Materials and methods: The study was conducted on patients diagnosed with retroperitoneal masses. FNA was performed under image guidance with the help of ultrasonography and/or computed tomography; smears were prepared and meticulously screened according to a fixed protocol. The results were analyzed to determine sensitivity, specificity, and diagnostic efficacy of cytopathological diagnosis using image-guided FNA techniques.

Results: We assessed 38 patients with retroperitoneal masses. In all cases, adequate cellular material was obtained. No major complications were encountered. Statistical analysis was carried out in 35 cases; sensitivity, specificity, and diagnostic accuracy were 100% in these cases.

Conclusion: FNA under image guidance should be considered a first-line diagnostic approach for retroperitoneal and other abdominal tumors, although caution should be exercised in case selection. In areas where advanced tests are not available, the cytotechnologist and cytopathologist have a very important role to play in ensuring accurate diagnoses.

No MeSH data available.


Related in: MedlinePlus

(a) Renal cyst: Cytospin preparation of aspirated fluid showing numerous macrophages in a clear background (H and E,×250); (b) Renal cell carcinoma: Large cells with abundant vacuolated cytoplasm and atypical nuclei against a hemorrhagic background (H and E, ×500); (c) Adrenal cyst: Hemorrhagic aspirate with foamy macrophages (H and E, ×250); (d) Adrenal adenocarcinoma: Papillary clusters of malignant cells with eosinophilic, vacuolated cytoplasm and overlapping, hyperchromatic nuclei with coarse chromatin (H and E, ×500)
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Figure 2: (a) Renal cyst: Cytospin preparation of aspirated fluid showing numerous macrophages in a clear background (H and E,×250); (b) Renal cell carcinoma: Large cells with abundant vacuolated cytoplasm and atypical nuclei against a hemorrhagic background (H and E, ×500); (c) Adrenal cyst: Hemorrhagic aspirate with foamy macrophages (H and E, ×250); (d) Adrenal adenocarcinoma: Papillary clusters of malignant cells with eosinophilic, vacuolated cytoplasm and overlapping, hyperchromatic nuclei with coarse chromatin (H and E, ×500)

Mentions: Aspirates from benign renal cysts revealed degenerating epithelial cells and numerous macrophages scattered in a clear background [Figure 2a]. In cases of renal cell carcinoma, smears were rich in cells, which were arranged singly or in cohesive sheets and dominated by hemorrhage and necrosis. The cells were large, with abundant pale to pink, finely vacuolated or granular cytoplasm and large, atypical nuclei [Figure 2b].


Image-guided fine-needle aspiration of retroperitoneal masses: The role of the cytopathologist.

Mehdi G, Maheshwari V, Afzal S, Ansari HA, Ahmad I - J Cytol (2013)

(a) Renal cyst: Cytospin preparation of aspirated fluid showing numerous macrophages in a clear background (H and E,×250); (b) Renal cell carcinoma: Large cells with abundant vacuolated cytoplasm and atypical nuclei against a hemorrhagic background (H and E, ×500); (c) Adrenal cyst: Hemorrhagic aspirate with foamy macrophages (H and E, ×250); (d) Adrenal adenocarcinoma: Papillary clusters of malignant cells with eosinophilic, vacuolated cytoplasm and overlapping, hyperchromatic nuclei with coarse chromatin (H and E, ×500)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643360&req=5

Figure 2: (a) Renal cyst: Cytospin preparation of aspirated fluid showing numerous macrophages in a clear background (H and E,×250); (b) Renal cell carcinoma: Large cells with abundant vacuolated cytoplasm and atypical nuclei against a hemorrhagic background (H and E, ×500); (c) Adrenal cyst: Hemorrhagic aspirate with foamy macrophages (H and E, ×250); (d) Adrenal adenocarcinoma: Papillary clusters of malignant cells with eosinophilic, vacuolated cytoplasm and overlapping, hyperchromatic nuclei with coarse chromatin (H and E, ×500)
Mentions: Aspirates from benign renal cysts revealed degenerating epithelial cells and numerous macrophages scattered in a clear background [Figure 2a]. In cases of renal cell carcinoma, smears were rich in cells, which were arranged singly or in cohesive sheets and dominated by hemorrhage and necrosis. The cells were large, with abundant pale to pink, finely vacuolated or granular cytoplasm and large, atypical nuclei [Figure 2b].

Bottom Line: The results were analyzed to determine sensitivity, specificity, and diagnostic efficacy of cytopathological diagnosis using image-guided FNA techniques.No major complications were encountered.In areas where advanced tests are not available, the cytotechnologist and cytopathologist have a very important role to play in ensuring accurate diagnoses.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

ABSTRACT

Background: Retroperitoneal tumors constitute a difficult diagnostic category as they are not easily accessible. The advent of image-guided fine-needle aspiration (FNA) has resolved this problem significantly.

Aims: We present a short study based on guided aspiration of retroperitoneal tumors, in which we have tried to assess the role of image-guided fine-needle aspiration cytology as a tool for pre-operative diagnosis.

Materials and methods: The study was conducted on patients diagnosed with retroperitoneal masses. FNA was performed under image guidance with the help of ultrasonography and/or computed tomography; smears were prepared and meticulously screened according to a fixed protocol. The results were analyzed to determine sensitivity, specificity, and diagnostic efficacy of cytopathological diagnosis using image-guided FNA techniques.

Results: We assessed 38 patients with retroperitoneal masses. In all cases, adequate cellular material was obtained. No major complications were encountered. Statistical analysis was carried out in 35 cases; sensitivity, specificity, and diagnostic accuracy were 100% in these cases.

Conclusion: FNA under image guidance should be considered a first-line diagnostic approach for retroperitoneal and other abdominal tumors, although caution should be exercised in case selection. In areas where advanced tests are not available, the cytotechnologist and cytopathologist have a very important role to play in ensuring accurate diagnoses.

No MeSH data available.


Related in: MedlinePlus