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Insight to neoplastic thyroid lesions by fine needle aspiration cytology.

Rangaswamy M, Narendra K, Patel S, Gururajprasad C, Manjunath G - J Cytol (2013)

Bottom Line: The sensitivity of FNAC was 75.60%, and positive predictive value was 83.78% for malignant lesions.FNAC is a rapid, efficient, cost-effective, relatively painless procedure with a high diagnostic accuracy.Hence, it is a valuable tool in the diagnosis and management of patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, JSS Medical College and Hospital, JSS University, Mysore, Karnataka, India.

ABSTRACT

Background: Fine needle aspiration cytology (FNAC) is a valuable adjunct to pre-operative screening in the diagnosis of thyroid nodules, and in most cases, it can distinguish between benign and malignant lesions.

Aim: To study the cytology of neoplastic thyroid lesions to minimize surgical intervention and for confirmation of the diagnosis by histopathological study.

Materials and methods: 100 cases of thyroid FNAC smears were analyzed and cyto-histopathological correlation was done in 47 cases. Galen and Gambino's method was used to calculate the sensitivity and positive predictive value.

Results: Of the 100 cases, 90 were diagnosed as neoplastic lesions by FNAC and ten cases as non-neoplastic lesions, which turned out to be neoplasms on histopathological study. Among 100 cases, 47 were biopsied and subjected to histopathological study. The sensitivity of FNAC was 75.60%, and positive predictive value was 83.78% for malignant lesions.

Conclusions: FNAC is a rapid, efficient, cost-effective, relatively painless procedure with a high diagnostic accuracy. It has high rate of sensitivity and positive predictive value in diagnosing thyroid neoplastic lesions. Hence, it is a valuable tool in the diagnosis and management of patients.

No MeSH data available.


Related in: MedlinePlus

(a) Medullary carcinoma: Cellular smear showing poorly cohesive cells with a plasmacytoid appearance and moderate anisokaryosis. Occasional binucleate cells seen (Pap, ×400); (b) Anaplastic spindle cell carcinoma showing cluster of pleomorphic plump spindle cells with hyperchromatic nuclei (Pap, ×400); (c) Metastatic renal cell carcinoma: Sheets of clear cells having hyperchromatic nucleus (MGG, ×400); (d) Metastatic renal cell carcinoma in thyroid: Section showing a clear cell lesion with adjacent normal looking thyroid tissue (H and E, ×100)
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Figure 2: (a) Medullary carcinoma: Cellular smear showing poorly cohesive cells with a plasmacytoid appearance and moderate anisokaryosis. Occasional binucleate cells seen (Pap, ×400); (b) Anaplastic spindle cell carcinoma showing cluster of pleomorphic plump spindle cells with hyperchromatic nuclei (Pap, ×400); (c) Metastatic renal cell carcinoma: Sheets of clear cells having hyperchromatic nucleus (MGG, ×400); (d) Metastatic renal cell carcinoma in thyroid: Section showing a clear cell lesion with adjacent normal looking thyroid tissue (H and E, ×100)

Mentions: Two cases of medullary carcinoma were diagnosed by FNAC in a 63-yr-old male and 51-yr-old female, but histopathological correlation was not possible [Figure 2]. FNAC diagnosis of spindle cell variant of anaplastic carcinoma was offered in two elderly female patients. However, histopathological correlation was not available.


Insight to neoplastic thyroid lesions by fine needle aspiration cytology.

Rangaswamy M, Narendra K, Patel S, Gururajprasad C, Manjunath G - J Cytol (2013)

(a) Medullary carcinoma: Cellular smear showing poorly cohesive cells with a plasmacytoid appearance and moderate anisokaryosis. Occasional binucleate cells seen (Pap, ×400); (b) Anaplastic spindle cell carcinoma showing cluster of pleomorphic plump spindle cells with hyperchromatic nuclei (Pap, ×400); (c) Metastatic renal cell carcinoma: Sheets of clear cells having hyperchromatic nucleus (MGG, ×400); (d) Metastatic renal cell carcinoma in thyroid: Section showing a clear cell lesion with adjacent normal looking thyroid tissue (H and E, ×100)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643357&req=5

Figure 2: (a) Medullary carcinoma: Cellular smear showing poorly cohesive cells with a plasmacytoid appearance and moderate anisokaryosis. Occasional binucleate cells seen (Pap, ×400); (b) Anaplastic spindle cell carcinoma showing cluster of pleomorphic plump spindle cells with hyperchromatic nuclei (Pap, ×400); (c) Metastatic renal cell carcinoma: Sheets of clear cells having hyperchromatic nucleus (MGG, ×400); (d) Metastatic renal cell carcinoma in thyroid: Section showing a clear cell lesion with adjacent normal looking thyroid tissue (H and E, ×100)
Mentions: Two cases of medullary carcinoma were diagnosed by FNAC in a 63-yr-old male and 51-yr-old female, but histopathological correlation was not possible [Figure 2]. FNAC diagnosis of spindle cell variant of anaplastic carcinoma was offered in two elderly female patients. However, histopathological correlation was not available.

Bottom Line: The sensitivity of FNAC was 75.60%, and positive predictive value was 83.78% for malignant lesions.FNAC is a rapid, efficient, cost-effective, relatively painless procedure with a high diagnostic accuracy.Hence, it is a valuable tool in the diagnosis and management of patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, JSS Medical College and Hospital, JSS University, Mysore, Karnataka, India.

ABSTRACT

Background: Fine needle aspiration cytology (FNAC) is a valuable adjunct to pre-operative screening in the diagnosis of thyroid nodules, and in most cases, it can distinguish between benign and malignant lesions.

Aim: To study the cytology of neoplastic thyroid lesions to minimize surgical intervention and for confirmation of the diagnosis by histopathological study.

Materials and methods: 100 cases of thyroid FNAC smears were analyzed and cyto-histopathological correlation was done in 47 cases. Galen and Gambino's method was used to calculate the sensitivity and positive predictive value.

Results: Of the 100 cases, 90 were diagnosed as neoplastic lesions by FNAC and ten cases as non-neoplastic lesions, which turned out to be neoplasms on histopathological study. Among 100 cases, 47 were biopsied and subjected to histopathological study. The sensitivity of FNAC was 75.60%, and positive predictive value was 83.78% for malignant lesions.

Conclusions: FNAC is a rapid, efficient, cost-effective, relatively painless procedure with a high diagnostic accuracy. It has high rate of sensitivity and positive predictive value in diagnosing thyroid neoplastic lesions. Hence, it is a valuable tool in the diagnosis and management of patients.

No MeSH data available.


Related in: MedlinePlus