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Insight to neoplastic thyroid lesions by fine needle aspiration cytology.

Rangaswamy M, Narendra K, Patel S, Gururajprasad C, Manjunath G - J Cytol (2013)

Bottom Line: The sensitivity of FNAC was 75.60%, and positive predictive value was 83.78% for malignant lesions.FNAC is a rapid, efficient, cost-effective, relatively painless procedure with a high diagnostic accuracy.Hence, it is a valuable tool in the diagnosis and management of patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, JSS Medical College and Hospital, JSS University, Mysore, Karnataka, India.

ABSTRACT

Background: Fine needle aspiration cytology (FNAC) is a valuable adjunct to pre-operative screening in the diagnosis of thyroid nodules, and in most cases, it can distinguish between benign and malignant lesions.

Aim: To study the cytology of neoplastic thyroid lesions to minimize surgical intervention and for confirmation of the diagnosis by histopathological study.

Materials and methods: 100 cases of thyroid FNAC smears were analyzed and cyto-histopathological correlation was done in 47 cases. Galen and Gambino's method was used to calculate the sensitivity and positive predictive value.

Results: Of the 100 cases, 90 were diagnosed as neoplastic lesions by FNAC and ten cases as non-neoplastic lesions, which turned out to be neoplasms on histopathological study. Among 100 cases, 47 were biopsied and subjected to histopathological study. The sensitivity of FNAC was 75.60%, and positive predictive value was 83.78% for malignant lesions.

Conclusions: FNAC is a rapid, efficient, cost-effective, relatively painless procedure with a high diagnostic accuracy. It has high rate of sensitivity and positive predictive value in diagnosing thyroid neoplastic lesions. Hence, it is a valuable tool in the diagnosis and management of patients.

No MeSH data available.


Related in: MedlinePlus

(a) Follicular neoplasm: Cellular smear with cells arranged in microfollicular pattern with anisokaryosis (MGG, ×200); (b) Follicular carcinoma: Tissue section showing vascular invasion (H and E, ×100); (c) Hurthle cell neoplasm: Cellular smear with sheets of oxyphilic cells having abundant granular cytoplasm and eccentrically placed nucleus (Pap, ×200); (d) Papillary carcinoma: Smear showing tumor cells with chewing gum colloid and psamomma body (H and E, ×200)
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Figure 1: (a) Follicular neoplasm: Cellular smear with cells arranged in microfollicular pattern with anisokaryosis (MGG, ×200); (b) Follicular carcinoma: Tissue section showing vascular invasion (H and E, ×100); (c) Hurthle cell neoplasm: Cellular smear with sheets of oxyphilic cells having abundant granular cytoplasm and eccentrically placed nucleus (Pap, ×200); (d) Papillary carcinoma: Smear showing tumor cells with chewing gum colloid and psamomma body (H and E, ×200)

Mentions: Cytological diagnosis of follicular neoplasm [56 cases] included a single case of Hurthle cell adenoma [Figure 1]. Histopathological correlation was done in 21 cases with a diagnostic accuracy of 76.19%. Six cases proved to be wrong, which included colloid goiter [4 cases], follicular variant of papillary carcinoma [1 case], and follicular carcinoma [1 case].


Insight to neoplastic thyroid lesions by fine needle aspiration cytology.

Rangaswamy M, Narendra K, Patel S, Gururajprasad C, Manjunath G - J Cytol (2013)

(a) Follicular neoplasm: Cellular smear with cells arranged in microfollicular pattern with anisokaryosis (MGG, ×200); (b) Follicular carcinoma: Tissue section showing vascular invasion (H and E, ×100); (c) Hurthle cell neoplasm: Cellular smear with sheets of oxyphilic cells having abundant granular cytoplasm and eccentrically placed nucleus (Pap, ×200); (d) Papillary carcinoma: Smear showing tumor cells with chewing gum colloid and psamomma body (H and E, ×200)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643357&req=5

Figure 1: (a) Follicular neoplasm: Cellular smear with cells arranged in microfollicular pattern with anisokaryosis (MGG, ×200); (b) Follicular carcinoma: Tissue section showing vascular invasion (H and E, ×100); (c) Hurthle cell neoplasm: Cellular smear with sheets of oxyphilic cells having abundant granular cytoplasm and eccentrically placed nucleus (Pap, ×200); (d) Papillary carcinoma: Smear showing tumor cells with chewing gum colloid and psamomma body (H and E, ×200)
Mentions: Cytological diagnosis of follicular neoplasm [56 cases] included a single case of Hurthle cell adenoma [Figure 1]. Histopathological correlation was done in 21 cases with a diagnostic accuracy of 76.19%. Six cases proved to be wrong, which included colloid goiter [4 cases], follicular variant of papillary carcinoma [1 case], and follicular carcinoma [1 case].

Bottom Line: The sensitivity of FNAC was 75.60%, and positive predictive value was 83.78% for malignant lesions.FNAC is a rapid, efficient, cost-effective, relatively painless procedure with a high diagnostic accuracy.Hence, it is a valuable tool in the diagnosis and management of patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, JSS Medical College and Hospital, JSS University, Mysore, Karnataka, India.

ABSTRACT

Background: Fine needle aspiration cytology (FNAC) is a valuable adjunct to pre-operative screening in the diagnosis of thyroid nodules, and in most cases, it can distinguish between benign and malignant lesions.

Aim: To study the cytology of neoplastic thyroid lesions to minimize surgical intervention and for confirmation of the diagnosis by histopathological study.

Materials and methods: 100 cases of thyroid FNAC smears were analyzed and cyto-histopathological correlation was done in 47 cases. Galen and Gambino's method was used to calculate the sensitivity and positive predictive value.

Results: Of the 100 cases, 90 were diagnosed as neoplastic lesions by FNAC and ten cases as non-neoplastic lesions, which turned out to be neoplasms on histopathological study. Among 100 cases, 47 were biopsied and subjected to histopathological study. The sensitivity of FNAC was 75.60%, and positive predictive value was 83.78% for malignant lesions.

Conclusions: FNAC is a rapid, efficient, cost-effective, relatively painless procedure with a high diagnostic accuracy. It has high rate of sensitivity and positive predictive value in diagnosing thyroid neoplastic lesions. Hence, it is a valuable tool in the diagnosis and management of patients.

No MeSH data available.


Related in: MedlinePlus