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Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial.

Castillo AL, Osi MO, Ramos JD, De Francia JL, Dujunco MU, Quilala PF - J Pharmacol Pharmacother (2013)

Bottom Line: To evaluate the clinical efficacy and safety of Tinospora cordifolia lotion including its cure rate and clearance time compared with permethrin lotion.T. cordifolia lotion and permethrin significantly reduced the mean global evaluation score after four weeks of treatment.The two lotions showed comparable effects as anti-scabies agent.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy, University of Santo Tomas, Manila, Philippines.

ABSTRACT

Objective: To evaluate the clinical efficacy and safety of Tinospora cordifolia lotion including its cure rate and clearance time compared with permethrin lotion.

Materials and methods: A single blind, randomized, controlled, pilot clinical study was performed in three government institutions to investigate clinical efficacy of T. cordifolia lotion in sixty-six clinically-diagnosed scabies-infected patients. The patients were treated with T. cordifolia or permethrin lotions for three consecutive days for two weeks and clinical assessment of each patient was performed for five weeks.

Results: T. cordifolia lotion and permethrin significantly reduced the mean global evaluation score after four weeks of treatment. The two lotions showed comparable effects as anti-scabies agent. Moreover, the clearance time (days) and cure rate using the two lotions did not differ. Clinical improvement, mean clearance time and cure rate of T. cordifolia lotion are comparable with permethrin.

Conclusions: Tinospora cordifolia lotion exhibits anti-scabies activity comparable with permethrin. Its incorporation as therapeutic reagent in Sarcoptes scabiei infections is highly recommended.

No MeSH data available.


Related in: MedlinePlus

Frequency Distribution of Severity of Pruritus, Erythema and Burning Sensation among T. cordifolia-treated Patients
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Figure 4: Frequency Distribution of Severity of Pruritus, Erythema and Burning Sensation among T. cordifolia-treated Patients

Mentions: Fourteen patients assigned to T. cordifolia lotion experienced pruritus, while five patients had erythema and six had burning sensation during application of the lotion. In terms of permethrin, fourteen patients had pruritus, five had erythema and another five had burning sensation during application. Most of the patients experienced mild severity of pruritus, rarely disturbing their sleep or any activity of the patient accompanied by occasional itching, with faint, barely discernible erythema and mild burning sensation [Figure 3]. Improvement in the condition was observed over time. There was reduction in the severity of the side effects experienced by the patients from the first day of application up to the last day of observation. Both T. cordifolia and permethrin lotions exhibited mild adverse effects in the same proportion of patients who had pruritus (P = 0.796), erythema (P = 0.553) and who had experienced burning sensation (P = 0.692) during treatment.


Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial.

Castillo AL, Osi MO, Ramos JD, De Francia JL, Dujunco MU, Quilala PF - J Pharmacol Pharmacother (2013)

Frequency Distribution of Severity of Pruritus, Erythema and Burning Sensation among T. cordifolia-treated Patients
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643341&req=5

Figure 4: Frequency Distribution of Severity of Pruritus, Erythema and Burning Sensation among T. cordifolia-treated Patients
Mentions: Fourteen patients assigned to T. cordifolia lotion experienced pruritus, while five patients had erythema and six had burning sensation during application of the lotion. In terms of permethrin, fourteen patients had pruritus, five had erythema and another five had burning sensation during application. Most of the patients experienced mild severity of pruritus, rarely disturbing their sleep or any activity of the patient accompanied by occasional itching, with faint, barely discernible erythema and mild burning sensation [Figure 3]. Improvement in the condition was observed over time. There was reduction in the severity of the side effects experienced by the patients from the first day of application up to the last day of observation. Both T. cordifolia and permethrin lotions exhibited mild adverse effects in the same proportion of patients who had pruritus (P = 0.796), erythema (P = 0.553) and who had experienced burning sensation (P = 0.692) during treatment.

Bottom Line: To evaluate the clinical efficacy and safety of Tinospora cordifolia lotion including its cure rate and clearance time compared with permethrin lotion.T. cordifolia lotion and permethrin significantly reduced the mean global evaluation score after four weeks of treatment.The two lotions showed comparable effects as anti-scabies agent.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy, University of Santo Tomas, Manila, Philippines.

ABSTRACT

Objective: To evaluate the clinical efficacy and safety of Tinospora cordifolia lotion including its cure rate and clearance time compared with permethrin lotion.

Materials and methods: A single blind, randomized, controlled, pilot clinical study was performed in three government institutions to investigate clinical efficacy of T. cordifolia lotion in sixty-six clinically-diagnosed scabies-infected patients. The patients were treated with T. cordifolia or permethrin lotions for three consecutive days for two weeks and clinical assessment of each patient was performed for five weeks.

Results: T. cordifolia lotion and permethrin significantly reduced the mean global evaluation score after four weeks of treatment. The two lotions showed comparable effects as anti-scabies agent. Moreover, the clearance time (days) and cure rate using the two lotions did not differ. Clinical improvement, mean clearance time and cure rate of T. cordifolia lotion are comparable with permethrin.

Conclusions: Tinospora cordifolia lotion exhibits anti-scabies activity comparable with permethrin. Its incorporation as therapeutic reagent in Sarcoptes scabiei infections is highly recommended.

No MeSH data available.


Related in: MedlinePlus