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Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial.

Castillo AL, Osi MO, Ramos JD, De Francia JL, Dujunco MU, Quilala PF - J Pharmacol Pharmacother (2013)

Bottom Line: To evaluate the clinical efficacy and safety of Tinospora cordifolia lotion including its cure rate and clearance time compared with permethrin lotion.T. cordifolia lotion and permethrin significantly reduced the mean global evaluation score after four weeks of treatment.The two lotions showed comparable effects as anti-scabies agent.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy, University of Santo Tomas, Manila, Philippines.

ABSTRACT

Objective: To evaluate the clinical efficacy and safety of Tinospora cordifolia lotion including its cure rate and clearance time compared with permethrin lotion.

Materials and methods: A single blind, randomized, controlled, pilot clinical study was performed in three government institutions to investigate clinical efficacy of T. cordifolia lotion in sixty-six clinically-diagnosed scabies-infected patients. The patients were treated with T. cordifolia or permethrin lotions for three consecutive days for two weeks and clinical assessment of each patient was performed for five weeks.

Results: T. cordifolia lotion and permethrin significantly reduced the mean global evaluation score after four weeks of treatment. The two lotions showed comparable effects as anti-scabies agent. Moreover, the clearance time (days) and cure rate using the two lotions did not differ. Clinical improvement, mean clearance time and cure rate of T. cordifolia lotion are comparable with permethrin.

Conclusions: Tinospora cordifolia lotion exhibits anti-scabies activity comparable with permethrin. Its incorporation as therapeutic reagent in Sarcoptes scabiei infections is highly recommended.

No MeSH data available.


Related in: MedlinePlus

The frequency distribution of clinical improvement among patients
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Figure 2: The frequency distribution of clinical improvement among patients

Mentions: From the T. cordifolia-treated patients who completed the follow-up, on seventh day of treatment (n = 30), 3.33% had mild improvement, 30% had moderate, while 56.66% and 6.66% had marked and excellent improvement and 3.33% were cleared of lesions. On day 28, majority of the patients (70%) had clearance of lesions while 3.33% each for failure treatment and worsened condition [Figure 1].


Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial.

Castillo AL, Osi MO, Ramos JD, De Francia JL, Dujunco MU, Quilala PF - J Pharmacol Pharmacother (2013)

The frequency distribution of clinical improvement among patients
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643341&req=5

Figure 2: The frequency distribution of clinical improvement among patients
Mentions: From the T. cordifolia-treated patients who completed the follow-up, on seventh day of treatment (n = 30), 3.33% had mild improvement, 30% had moderate, while 56.66% and 6.66% had marked and excellent improvement and 3.33% were cleared of lesions. On day 28, majority of the patients (70%) had clearance of lesions while 3.33% each for failure treatment and worsened condition [Figure 1].

Bottom Line: To evaluate the clinical efficacy and safety of Tinospora cordifolia lotion including its cure rate and clearance time compared with permethrin lotion.T. cordifolia lotion and permethrin significantly reduced the mean global evaluation score after four weeks of treatment.The two lotions showed comparable effects as anti-scabies agent.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy, University of Santo Tomas, Manila, Philippines.

ABSTRACT

Objective: To evaluate the clinical efficacy and safety of Tinospora cordifolia lotion including its cure rate and clearance time compared with permethrin lotion.

Materials and methods: A single blind, randomized, controlled, pilot clinical study was performed in three government institutions to investigate clinical efficacy of T. cordifolia lotion in sixty-six clinically-diagnosed scabies-infected patients. The patients were treated with T. cordifolia or permethrin lotions for three consecutive days for two weeks and clinical assessment of each patient was performed for five weeks.

Results: T. cordifolia lotion and permethrin significantly reduced the mean global evaluation score after four weeks of treatment. The two lotions showed comparable effects as anti-scabies agent. Moreover, the clearance time (days) and cure rate using the two lotions did not differ. Clinical improvement, mean clearance time and cure rate of T. cordifolia lotion are comparable with permethrin.

Conclusions: Tinospora cordifolia lotion exhibits anti-scabies activity comparable with permethrin. Its incorporation as therapeutic reagent in Sarcoptes scabiei infections is highly recommended.

No MeSH data available.


Related in: MedlinePlus