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Continuous arterial and venous glucose monitoring by quenched chemical fluorescence in ICU patients after cardiac surgery

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Continuous glucose monitoring (CGM) in ICUs has the potential to improve patient safety outcomes... The GluCath Intravascular CGM System uses a novel quenched chemical fluorescence sensing mechanism to measure glucose concentration in venous or arterial blood (BG)... An arterial sensor is deployed via a standard 20 G radial artery catheter inserted for routine care and an optional venous sensor is deployed percutaneously in an upper arm vein... Hourly arterial reference samples were analyzed via Radiometer ABL 800 Flex Blood Gas Analyzer (BGA)... Arterial sensors were successfully deployed in all five patients and did not interfere with clinical care, blood pressure monitoring or sampling... One arterial catheter failed resulting in sensor removal at 36 hours... Precision between arterial and venous sensors (n = 2) was 9.3% CV... Arterial sensor accuracy compared with BGA was 5.5% MARD... One hundred percent (202/202) of arterial sensor measurements met ISO 15197 criteria (within =/-20% of reference measurements if BG = 4.2 mmol/l; Figure 1)... The GluCath System measured glucose concentration continuously in cardiac surgery ICU patients... Arterial catheter deployment did not appear to compromise line function or patient care.

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Arterial sensor ISO-modified Bland-Altman plot.
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Figure 1: Arterial sensor ISO-modified Bland-Altman plot.

Mentions: Arterial sensors were successfully deployed in all five patients and did not interfere with clinical care, blood pressure monitoring or sampling. One arterial catheter failed resulting in sensor removal at 36 hours. The venous sensor was deployed in three patients, but removed from two patients due to thrombosis identified during surveillance ultrasound examinations. A total of 202 reference BG samples ranging from 5.3 to 11.3 mmol/l were collected. Precision between arterial and venous sensors (n = 2) was 9.3% CV. Arterial sensor accuracy compared with BGA was 5.5% MARD. One hundred percent (202/202) of arterial sensor measurements met ISO 15197 criteria (within =/-20% of reference measurements if BG = 4.2 mmol/l; Figure 1).


Continuous arterial and venous glucose monitoring by quenched chemical fluorescence in ICU patients after cardiac surgery
Arterial sensor ISO-modified Bland-Altman plot.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643151&req=5

Figure 1: Arterial sensor ISO-modified Bland-Altman plot.
Mentions: Arterial sensors were successfully deployed in all five patients and did not interfere with clinical care, blood pressure monitoring or sampling. One arterial catheter failed resulting in sensor removal at 36 hours. The venous sensor was deployed in three patients, but removed from two patients due to thrombosis identified during surveillance ultrasound examinations. A total of 202 reference BG samples ranging from 5.3 to 11.3 mmol/l were collected. Precision between arterial and venous sensors (n = 2) was 9.3% CV. Arterial sensor accuracy compared with BGA was 5.5% MARD. One hundred percent (202/202) of arterial sensor measurements met ISO 15197 criteria (within =/-20% of reference measurements if BG = 4.2 mmol/l; Figure 1).

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Continuous glucose monitoring (CGM) in ICUs has the potential to improve patient safety outcomes... The GluCath Intravascular CGM System uses a novel quenched chemical fluorescence sensing mechanism to measure glucose concentration in venous or arterial blood (BG)... An arterial sensor is deployed via a standard 20 G radial artery catheter inserted for routine care and an optional venous sensor is deployed percutaneously in an upper arm vein... Hourly arterial reference samples were analyzed via Radiometer ABL 800 Flex Blood Gas Analyzer (BGA)... Arterial sensors were successfully deployed in all five patients and did not interfere with clinical care, blood pressure monitoring or sampling... One arterial catheter failed resulting in sensor removal at 36 hours... Precision between arterial and venous sensors (n = 2) was 9.3% CV... Arterial sensor accuracy compared with BGA was 5.5% MARD... One hundred percent (202/202) of arterial sensor measurements met ISO 15197 criteria (within =/-20% of reference measurements if BG = 4.2 mmol/l; Figure 1)... The GluCath System measured glucose concentration continuously in cardiac surgery ICU patients... Arterial catheter deployment did not appear to compromise line function or patient care.

No MeSH data available.