Mentions: Endogenous melatonin was found lower in critically ill patients compared with healthy subjects (Figure 1), although it showed a great individual variability and it generally maintained a night-time increase. In the univariate analysis the peak was found related to: blood creatinine (P = 0.034); patients in coma (P = 0.024); hospital mortality (P = 0.016). The AUC was found related to: SAPS II (P = 0.047); creatinine (P 0.001); AST (P 0.001); ALT (P 0.001); hospital mortality (P 0.022). Peak and AUC were found higher in nonsurvivor patients.
No MeSH data available.