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Prevalence of latex allergy in spina bifida patients in Singapore.

Chua X, Mohamed J, van Bever HP - Asia Pac Allergy (2013)

Bottom Line: While studies have been well-established in Europe and America, data from Asia are limited.Only 6 (38%) subjects had allergy to the food allergens tested.This number is comparable to that in Europe and America.

View Article: PubMed Central - PubMed

Affiliation: University Children's Medical Institute, National University Hospital, Singapore 119228, Singapore.

ABSTRACT

Background: Latex allergy and its clinical presentation are rising in prevalence across the globe, especially amongst patients with spina bifida (SB). While studies have been well-established in Europe and America, data from Asia are limited.

Objective: The aim of this study is to investigate the scenario in Singapore.

Methods: 35 subjects with SB, aged 5 to 32 years answered a questionnaire and underwent skin prick test (SPT) using a latex solution, 3 common house dust mites and 3 commonly cross-reacting food allergens (banana, kiwi and avocado). We also noted the relation between latex sensitization with atopy and doctor-diagnosed allergy. The prevalence of cross-reactivity with fruits was also studied.

Results: Sensitization to latex (i.e. a positive SPT) was found in 16 (46%, 95% confidence interval 29%-63%) of the subjects. Only 5 (31%) of the subjects who were sensitized to latex had clinical manifestations. Atopy (i.e. positive SPT to house dust mites) was present in 23 (66%) of the subjects and 13 (57%) of them was also sensitized to latex. There was a positive trend between latex sensitization and atopy (81.2% vs. 52.6%, p = 0.076), as well as latex sensitization with those having both atopy and doctor-diagnosed allergy (i.e. asthma, allergic rhinitis, eczema, drug allergy) (93.8% vs. 63.2%, p = 0.032). Only 6 (38%) subjects had allergy to the food allergens tested.

Conclusion: Almost half of the SB patients in Singapore are sensitized to latex. This number is comparable to that in Europe and America. Positive trend between latex sensitization and those with both atopy and doctor-diagnosed allergy (p = 0.032) is suggestive of a possible cause-effect relationship.

No MeSH data available.


Related in: MedlinePlus

Prevalence of sensitization to latex in individuals with and without atopy.
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Figure 2: Prevalence of sensitization to latex in individuals with and without atopy.

Mentions: Atopy was present in 23 (66%) of the subjects, of which 13 (57%) had latex allergy (Fig. 2). The prevalence of asthma, allergic rhinitis and eczema among the subjects were 6%, 29% and 11% respectively. The prevalence of drug allergy is 23%. Fig. 3 illustrates the prevalence of latex sensitization in those with doctor-diagnosed allergy.


Prevalence of latex allergy in spina bifida patients in Singapore.

Chua X, Mohamed J, van Bever HP - Asia Pac Allergy (2013)

Prevalence of sensitization to latex in individuals with and without atopy.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643061&req=5

Figure 2: Prevalence of sensitization to latex in individuals with and without atopy.
Mentions: Atopy was present in 23 (66%) of the subjects, of which 13 (57%) had latex allergy (Fig. 2). The prevalence of asthma, allergic rhinitis and eczema among the subjects were 6%, 29% and 11% respectively. The prevalence of drug allergy is 23%. Fig. 3 illustrates the prevalence of latex sensitization in those with doctor-diagnosed allergy.

Bottom Line: While studies have been well-established in Europe and America, data from Asia are limited.Only 6 (38%) subjects had allergy to the food allergens tested.This number is comparable to that in Europe and America.

View Article: PubMed Central - PubMed

Affiliation: University Children's Medical Institute, National University Hospital, Singapore 119228, Singapore.

ABSTRACT

Background: Latex allergy and its clinical presentation are rising in prevalence across the globe, especially amongst patients with spina bifida (SB). While studies have been well-established in Europe and America, data from Asia are limited.

Objective: The aim of this study is to investigate the scenario in Singapore.

Methods: 35 subjects with SB, aged 5 to 32 years answered a questionnaire and underwent skin prick test (SPT) using a latex solution, 3 common house dust mites and 3 commonly cross-reacting food allergens (banana, kiwi and avocado). We also noted the relation between latex sensitization with atopy and doctor-diagnosed allergy. The prevalence of cross-reactivity with fruits was also studied.

Results: Sensitization to latex (i.e. a positive SPT) was found in 16 (46%, 95% confidence interval 29%-63%) of the subjects. Only 5 (31%) of the subjects who were sensitized to latex had clinical manifestations. Atopy (i.e. positive SPT to house dust mites) was present in 23 (66%) of the subjects and 13 (57%) of them was also sensitized to latex. There was a positive trend between latex sensitization and atopy (81.2% vs. 52.6%, p = 0.076), as well as latex sensitization with those having both atopy and doctor-diagnosed allergy (i.e. asthma, allergic rhinitis, eczema, drug allergy) (93.8% vs. 63.2%, p = 0.032). Only 6 (38%) subjects had allergy to the food allergens tested.

Conclusion: Almost half of the SB patients in Singapore are sensitized to latex. This number is comparable to that in Europe and America. Positive trend between latex sensitization and those with both atopy and doctor-diagnosed allergy (p = 0.032) is suggestive of a possible cause-effect relationship.

No MeSH data available.


Related in: MedlinePlus