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Overview of atopic dermatitis.

Kim KH - Asia Pac Allergy (2013)

Bottom Line: AD has many different clinical features.AD can be controlled effectively with topical and/or systemic treatments and fortunately spontaneously disappears with age.However, in some cases very resistant to conventional therapies, additional treatments such as immunosuppressive agents are needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Seoul National University Hospital, Seoul 110-744, Korea.

ABSTRACT
Atopic dermatitis (AD) is a very common chronic disease that reportedly affects 10%-20% of the general population. The prevalence of AD appears to be steadily increasing, at least in developing countries. Two pathogenetic mechanisms have been mentioned. Traditionally immunological aberrations are thought to be a primary event in the initial development of AD ("inside-to-outside hypothesis"). Another hypothesis assumes that there is an intrinsic defect in epidermal barrier. Due to this barrier defect, allergens or irritants can easily penetrate the epidermal barrier, and induce immunologic reaction secondarily ("outside-to-inside hypothesis"). These days the epidermal barrier defect seems to gain more support as a primary event than immunological aberrations in the early changes of AD since the filaggrin mutation was reported in AD patients. Clinically AD initially affects face, and with age, flexural areas are typically involved. AD has many different clinical features. Diagnostic criteria for AD in each country may be a little different, although based on the criteria proposed by Hanifin and Rajka. AD can be controlled effectively with topical and/or systemic treatments and fortunately spontaneously disappears with age. However, in some cases very resistant to conventional therapies, additional treatments such as immunosuppressive agents are needed.

No MeSH data available.


Related in: MedlinePlus

Flexural areas are typically affected in patients over 2 yr.
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Figure 3: Flexural areas are typically affected in patients over 2 yr.

Mentions: Clinically it usually starts around 2 months of age, and affects face and extensor surface of extremities typically in those below 2 years of age. These predilection sites are actually exposed areas prone to external irritation. The area around the mouth is typically affected due to irritation of saliva (Fig. 2), and sometimes periorbital area is also involved due to irritation of tears. With age over 2 years, flexural areas such as antecubital fossa, popliteal fossa, neck, ankle, wrist, and infragluteal folds are typically involved (Fig. 3). Skin dryness is usually severe even in those areas not showing eczematous features.


Overview of atopic dermatitis.

Kim KH - Asia Pac Allergy (2013)

Flexural areas are typically affected in patients over 2 yr.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643056&req=5

Figure 3: Flexural areas are typically affected in patients over 2 yr.
Mentions: Clinically it usually starts around 2 months of age, and affects face and extensor surface of extremities typically in those below 2 years of age. These predilection sites are actually exposed areas prone to external irritation. The area around the mouth is typically affected due to irritation of saliva (Fig. 2), and sometimes periorbital area is also involved due to irritation of tears. With age over 2 years, flexural areas such as antecubital fossa, popliteal fossa, neck, ankle, wrist, and infragluteal folds are typically involved (Fig. 3). Skin dryness is usually severe even in those areas not showing eczematous features.

Bottom Line: AD has many different clinical features.AD can be controlled effectively with topical and/or systemic treatments and fortunately spontaneously disappears with age.However, in some cases very resistant to conventional therapies, additional treatments such as immunosuppressive agents are needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Seoul National University Hospital, Seoul 110-744, Korea.

ABSTRACT
Atopic dermatitis (AD) is a very common chronic disease that reportedly affects 10%-20% of the general population. The prevalence of AD appears to be steadily increasing, at least in developing countries. Two pathogenetic mechanisms have been mentioned. Traditionally immunological aberrations are thought to be a primary event in the initial development of AD ("inside-to-outside hypothesis"). Another hypothesis assumes that there is an intrinsic defect in epidermal barrier. Due to this barrier defect, allergens or irritants can easily penetrate the epidermal barrier, and induce immunologic reaction secondarily ("outside-to-inside hypothesis"). These days the epidermal barrier defect seems to gain more support as a primary event than immunological aberrations in the early changes of AD since the filaggrin mutation was reported in AD patients. Clinically AD initially affects face, and with age, flexural areas are typically involved. AD has many different clinical features. Diagnostic criteria for AD in each country may be a little different, although based on the criteria proposed by Hanifin and Rajka. AD can be controlled effectively with topical and/or systemic treatments and fortunately spontaneously disappears with age. However, in some cases very resistant to conventional therapies, additional treatments such as immunosuppressive agents are needed.

No MeSH data available.


Related in: MedlinePlus