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Staphylococcal enterotoxin specific IgE and asthma: a systematic review and meta-analysis.

Song WJ, Jo EJ, Lee JW, Kang HR, Cho SH, Min KU, Chang YS - Asia Pac Allergy (2013)

Bottom Line: Data were extracted on study designs, subjects, definitions and the prevalence of Staphylococcal enterotoxin sensitization.Staphylococcal enterotoxin sensitization was significantly associated with asthma.The mechanisms of associations warrant further elucidation.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea. ; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 110-799, Korea.

ABSTRACT

Background: Recent literature suggests that Staphylococcal enterotoxin specific IgE may be a risk factor for asthma.

Objective: To investigate the associations between Staphylococcal enterotoxin sensitization and asthma.

Methods: A systematic review and meta-analysis was performed for relevant case-control or population-based studies, published in the peer-reviewed journals until February 2013. Data were extracted on study designs, subjects, definitions and the prevalence of Staphylococcal enterotoxin sensitization.

Results: A total of 683 studies were initially identified, of which 7 studies finally met the inclusion criteria (5 case-control and 2 population-based studies). All the included studies reported higher prevalence of the sensitization in asthmatics than in controls, despite clinical and methodological heterogeneity. In a meta-analysis, the pooled odds ratio of the sensitization for asthma was 2.95 (95% confidence intervals 2.28-3.82).

Conclusion: Staphylococcal enterotoxin sensitization was significantly associated with asthma. The mechanisms of associations warrant further elucidation.

No MeSH data available.


Related in: MedlinePlus

Forest plots of studies comparing the frequency of Staphylococcal enterotoxin sensitization in asthmatics and controls. Green squares represent individual studies, and the size of squares is proportional to the number of subjects in the study. Horizontal lines indicate 95% confidence interval ranges. Vertical dotted lines and diamond shapes represent pooled summary estimates for the analysis (the width of the diamond represents the 95% CI).OR, odds ratio; 95% CI, 95% confidence interval; M-H, Mantel-Haenzel test; D+L, DerSimonian and Laird method.
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Figure 2: Forest plots of studies comparing the frequency of Staphylococcal enterotoxin sensitization in asthmatics and controls. Green squares represent individual studies, and the size of squares is proportional to the number of subjects in the study. Horizontal lines indicate 95% confidence interval ranges. Vertical dotted lines and diamond shapes represent pooled summary estimates for the analysis (the width of the diamond represents the 95% CI).OR, odds ratio; 95% CI, 95% confidence interval; M-H, Mantel-Haenzel test; D+L, DerSimonian and Laird method.

Mentions: The prevalence of SE sIgE positivity among asthmatics widely varied with study populations, ranging from 14.9% to 79.1%; however, the rates showed trends to increase in older subjects and in more severe asthmatics. In non-asthmatic controls, the rate of SE sensitization also ranged widely, from 3.8% to 41.3%. Collectively, all the included articles consistently showed that SE sensitization is more frequent among asthmatics than controls, irrespective of study populations. In the meta-analysis, the pooled odds ratio (OR) of SE sensitization for asthma was 2.95 (95% confidence interval [CI] 2.28-3.82, Fig. 2).


Staphylococcal enterotoxin specific IgE and asthma: a systematic review and meta-analysis.

Song WJ, Jo EJ, Lee JW, Kang HR, Cho SH, Min KU, Chang YS - Asia Pac Allergy (2013)

Forest plots of studies comparing the frequency of Staphylococcal enterotoxin sensitization in asthmatics and controls. Green squares represent individual studies, and the size of squares is proportional to the number of subjects in the study. Horizontal lines indicate 95% confidence interval ranges. Vertical dotted lines and diamond shapes represent pooled summary estimates for the analysis (the width of the diamond represents the 95% CI).OR, odds ratio; 95% CI, 95% confidence interval; M-H, Mantel-Haenzel test; D+L, DerSimonian and Laird method.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643054&req=5

Figure 2: Forest plots of studies comparing the frequency of Staphylococcal enterotoxin sensitization in asthmatics and controls. Green squares represent individual studies, and the size of squares is proportional to the number of subjects in the study. Horizontal lines indicate 95% confidence interval ranges. Vertical dotted lines and diamond shapes represent pooled summary estimates for the analysis (the width of the diamond represents the 95% CI).OR, odds ratio; 95% CI, 95% confidence interval; M-H, Mantel-Haenzel test; D+L, DerSimonian and Laird method.
Mentions: The prevalence of SE sIgE positivity among asthmatics widely varied with study populations, ranging from 14.9% to 79.1%; however, the rates showed trends to increase in older subjects and in more severe asthmatics. In non-asthmatic controls, the rate of SE sensitization also ranged widely, from 3.8% to 41.3%. Collectively, all the included articles consistently showed that SE sensitization is more frequent among asthmatics than controls, irrespective of study populations. In the meta-analysis, the pooled odds ratio (OR) of SE sensitization for asthma was 2.95 (95% confidence interval [CI] 2.28-3.82, Fig. 2).

Bottom Line: Data were extracted on study designs, subjects, definitions and the prevalence of Staphylococcal enterotoxin sensitization.Staphylococcal enterotoxin sensitization was significantly associated with asthma.The mechanisms of associations warrant further elucidation.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea. ; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 110-799, Korea.

ABSTRACT

Background: Recent literature suggests that Staphylococcal enterotoxin specific IgE may be a risk factor for asthma.

Objective: To investigate the associations between Staphylococcal enterotoxin sensitization and asthma.

Methods: A systematic review and meta-analysis was performed for relevant case-control or population-based studies, published in the peer-reviewed journals until February 2013. Data were extracted on study designs, subjects, definitions and the prevalence of Staphylococcal enterotoxin sensitization.

Results: A total of 683 studies were initially identified, of which 7 studies finally met the inclusion criteria (5 case-control and 2 population-based studies). All the included studies reported higher prevalence of the sensitization in asthmatics than in controls, despite clinical and methodological heterogeneity. In a meta-analysis, the pooled odds ratio of the sensitization for asthma was 2.95 (95% confidence intervals 2.28-3.82).

Conclusion: Staphylococcal enterotoxin sensitization was significantly associated with asthma. The mechanisms of associations warrant further elucidation.

No MeSH data available.


Related in: MedlinePlus