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Staphylococcal enterotoxin specific IgE and asthma: a systematic review and meta-analysis.

Song WJ, Jo EJ, Lee JW, Kang HR, Cho SH, Min KU, Chang YS - Asia Pac Allergy (2013)

Bottom Line: Data were extracted on study designs, subjects, definitions and the prevalence of Staphylococcal enterotoxin sensitization.Staphylococcal enterotoxin sensitization was significantly associated with asthma.The mechanisms of associations warrant further elucidation.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea. ; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 110-799, Korea.

ABSTRACT

Background: Recent literature suggests that Staphylococcal enterotoxin specific IgE may be a risk factor for asthma.

Objective: To investigate the associations between Staphylococcal enterotoxin sensitization and asthma.

Methods: A systematic review and meta-analysis was performed for relevant case-control or population-based studies, published in the peer-reviewed journals until February 2013. Data were extracted on study designs, subjects, definitions and the prevalence of Staphylococcal enterotoxin sensitization.

Results: A total of 683 studies were initially identified, of which 7 studies finally met the inclusion criteria (5 case-control and 2 population-based studies). All the included studies reported higher prevalence of the sensitization in asthmatics than in controls, despite clinical and methodological heterogeneity. In a meta-analysis, the pooled odds ratio of the sensitization for asthma was 2.95 (95% confidence intervals 2.28-3.82).

Conclusion: Staphylococcal enterotoxin sensitization was significantly associated with asthma. The mechanisms of associations warrant further elucidation.

No MeSH data available.


Related in: MedlinePlus

Flowchart for the identification of relevant studies.
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Figure 1: Flowchart for the identification of relevant studies.

Mentions: A systematic literature review was performed on Pubmed and Embase databases to identify peer-reviewed articles reporting the prevalence of SE sensitization in asthmatics and controls, published from January 1960 until February 2013, without language restriction. The search utilized the keywords 'asthma OR wheeze OR wheezing' AND 'Staphylococcal OR Staphylococcus'. Additional articles were manually sought through the reference lists of the retrieved articles. The review process followed the recommendations of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement [11], as presented in Fig. 1. Inclusion criteria were 1) the population-based or case-control studies which compared the prevalence of SE sensitization in asthmatics with non-asthmatic controls. Exclusion criteria were 1) the articles without peer-reviewed full-text (i.e., conference abstracts) and 2) the studies which did not determine the positivity of SE sensitization in a standardized manner.


Staphylococcal enterotoxin specific IgE and asthma: a systematic review and meta-analysis.

Song WJ, Jo EJ, Lee JW, Kang HR, Cho SH, Min KU, Chang YS - Asia Pac Allergy (2013)

Flowchart for the identification of relevant studies.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643054&req=5

Figure 1: Flowchart for the identification of relevant studies.
Mentions: A systematic literature review was performed on Pubmed and Embase databases to identify peer-reviewed articles reporting the prevalence of SE sensitization in asthmatics and controls, published from January 1960 until February 2013, without language restriction. The search utilized the keywords 'asthma OR wheeze OR wheezing' AND 'Staphylococcal OR Staphylococcus'. Additional articles were manually sought through the reference lists of the retrieved articles. The review process followed the recommendations of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement [11], as presented in Fig. 1. Inclusion criteria were 1) the population-based or case-control studies which compared the prevalence of SE sensitization in asthmatics with non-asthmatic controls. Exclusion criteria were 1) the articles without peer-reviewed full-text (i.e., conference abstracts) and 2) the studies which did not determine the positivity of SE sensitization in a standardized manner.

Bottom Line: Data were extracted on study designs, subjects, definitions and the prevalence of Staphylococcal enterotoxin sensitization.Staphylococcal enterotoxin sensitization was significantly associated with asthma.The mechanisms of associations warrant further elucidation.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea. ; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 110-799, Korea.

ABSTRACT

Background: Recent literature suggests that Staphylococcal enterotoxin specific IgE may be a risk factor for asthma.

Objective: To investigate the associations between Staphylococcal enterotoxin sensitization and asthma.

Methods: A systematic review and meta-analysis was performed for relevant case-control or population-based studies, published in the peer-reviewed journals until February 2013. Data were extracted on study designs, subjects, definitions and the prevalence of Staphylococcal enterotoxin sensitization.

Results: A total of 683 studies were initially identified, of which 7 studies finally met the inclusion criteria (5 case-control and 2 population-based studies). All the included studies reported higher prevalence of the sensitization in asthmatics than in controls, despite clinical and methodological heterogeneity. In a meta-analysis, the pooled odds ratio of the sensitization for asthma was 2.95 (95% confidence intervals 2.28-3.82).

Conclusion: Staphylococcal enterotoxin sensitization was significantly associated with asthma. The mechanisms of associations warrant further elucidation.

No MeSH data available.


Related in: MedlinePlus