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Multiscale modeling of acute insulin resistance in critical care

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Reduced glucose uptake driven by increased plasma IL-6 levels.
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Figure 1: Reduced glucose uptake driven by increased plasma IL-6 levels.

Mentions: Inhibitory dynamics driven by IL-6 were incorporated into the cellular model to attenuate an insulin signaling intermediate (insulin receptor substrate 1) according to the proposed biological mechanisms. The percentage reduction in glucose uptake as a function of IL-6 concentration was fit to data from patients who underwent elective abdominal surgery [2], shown in Figure 1. The overall multiscale model captures decreased insulin signaling as a result of increased IL-6 levels and the subsequent hyperglycemia that may ensue.


Multiscale modeling of acute insulin resistance in critical care
Reduced glucose uptake driven by increased plasma IL-6 levels.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643044&req=5

Figure 1: Reduced glucose uptake driven by increased plasma IL-6 levels.
Mentions: Inhibitory dynamics driven by IL-6 were incorporated into the cellular model to attenuate an insulin signaling intermediate (insulin receptor substrate 1) according to the proposed biological mechanisms. The percentage reduction in glucose uptake as a function of IL-6 concentration was fit to data from patients who underwent elective abdominal surgery [2], shown in Figure 1. The overall multiscale model captures decreased insulin signaling as a result of increased IL-6 levels and the subsequent hyperglycemia that may ensue.

View Article: PubMed Central - HTML

No MeSH data available.