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EADC Values in Diagnosis of Renal Lesions by 3.0 T Diffusion-Weighted Magnetic Resonance Imaging: Compared with the ADC Values.

Zhang YL, Yu BL, Ren J, Qu K, Wang K, Qiang YQ, Li CX, Sun XW - Appl Magn Reson (2012)

Bottom Line: We found renal cell carcinoma (RCC) can be distinguished from angiomyolipoma, and clear cell carcinoma can be distinguished from non-clear cell carcinoma by EADC value.In conclusion, EADC map shows the internal structure of the kidney tumor more intuitively than the ADC map dose, and is also in line with the observation habits of the clinicians.EADC can be used as an effective imaging method for tumor diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Imaging, First Affiliated Hospital, Medicine School of Xi'an Jiaotong University, Xi'an, 710061 Shaanxi People's Republic of China.

ABSTRACT
Exponential apparent diffusion coefficient (EADC) is an indicator of diffusion-weighted imaging (DWI) and reflects the pathological changes of tissues quantitatively. However, no study has been investigated in the space-occupying kidney disease using EADC values. This study aims to evaluate the diagnostic role of EADC values at a high magnetic field strength (3.0 T) in kidney neoplastic lesions, compared with that of the ADC values. Ninety patients with suspected renal tumors (including 101 suspected renal lesions) and 20 healthy volunteers were performed MRI scanning. Diffusion-weighted imaging was performed with a single-shot spin-echo echo-planar imaging (SE-EPI) sequence at a diffusion gradient of b = 500 s/mm(2). We found renal cell carcinoma (RCC) can be distinguished from angiomyolipoma, and clear cell carcinoma can be distinguished from non-clear cell carcinoma by EADC value. There was significant difference in overall EADC values between renal cell carcinoma (0.150 ± 0.059) and angiomyolipoma (0.270 ± 0.108) when b value was 500 s/mm(2). When receiver operating characteristic (ROC) was higher than 0.192, the sensitivity and specificity of EADC value of renal cell carcinoma were 84.6 and 81.1 %, respectively. In conclusion, EADC map shows the internal structure of the kidney tumor more intuitively than the ADC map dose, and is also in line with the observation habits of the clinicians. EADC can be used as an effective imaging method for tumor diagnosis.

No MeSH data available.


Related in: MedlinePlus

DWI map, EADC map and ADC map showing the parenchymal part and cystic part of tumor at multiple levels. a DWI map: the overall ROI1 of tumor appears as mixed signals, with diffusion-restricted high signals in parenchymal part (ROI3) and equal signals in cystic part (ROI2); b EADC map: ROI1 0.134, ROI2 0.0752, ROI3 0.256; c ADC map ROI1 2.102 × 10−3 mm2/s, ROI2 2.601 × 10−3 mm2/s, ROI3 1.372 × 10−3 mm2/s
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Fig1: DWI map, EADC map and ADC map showing the parenchymal part and cystic part of tumor at multiple levels. a DWI map: the overall ROI1 of tumor appears as mixed signals, with diffusion-restricted high signals in parenchymal part (ROI3) and equal signals in cystic part (ROI2); b EADC map: ROI1 0.134, ROI2 0.0752, ROI3 0.256; c ADC map ROI1 2.102 × 10−3 mm2/s, ROI2 2.601 × 10−3 mm2/s, ROI3 1.372 × 10−3 mm2/s

Mentions: In the group of patients, ROI was set as following: first, at all the transversal sections (b = 0 s/mm2) showing the appearance of the tumor, circular or oval ROI was adopted if the shape of tumor was regular, and manual delineated ROI was adopted to include the entire tumor if the shape of tumor was irregular; second, EADC and ADC values of each level were measured and the average value was regarded as EADC and ADC values for the whole tumor. Then the parenchymal part and cystic part of tumor were outlined at multiple levels and the mean values of EADC and ADC were obtained (Fig. 1). For tumors rich in fatty tissue, in addition to the above methods, the fatty part and non-fatty part of tumor were outlined respectively to obtain the their each mean value. For cystic lesions, ROI included the cystic wall as much as possible. There are no units of measurement for EADC value. Data were mean values averaged from two measurements.Fig. 1


EADC Values in Diagnosis of Renal Lesions by 3.0 T Diffusion-Weighted Magnetic Resonance Imaging: Compared with the ADC Values.

Zhang YL, Yu BL, Ren J, Qu K, Wang K, Qiang YQ, Li CX, Sun XW - Appl Magn Reson (2012)

DWI map, EADC map and ADC map showing the parenchymal part and cystic part of tumor at multiple levels. a DWI map: the overall ROI1 of tumor appears as mixed signals, with diffusion-restricted high signals in parenchymal part (ROI3) and equal signals in cystic part (ROI2); b EADC map: ROI1 0.134, ROI2 0.0752, ROI3 0.256; c ADC map ROI1 2.102 × 10−3 mm2/s, ROI2 2.601 × 10−3 mm2/s, ROI3 1.372 × 10−3 mm2/s
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3585986&req=5

Fig1: DWI map, EADC map and ADC map showing the parenchymal part and cystic part of tumor at multiple levels. a DWI map: the overall ROI1 of tumor appears as mixed signals, with diffusion-restricted high signals in parenchymal part (ROI3) and equal signals in cystic part (ROI2); b EADC map: ROI1 0.134, ROI2 0.0752, ROI3 0.256; c ADC map ROI1 2.102 × 10−3 mm2/s, ROI2 2.601 × 10−3 mm2/s, ROI3 1.372 × 10−3 mm2/s
Mentions: In the group of patients, ROI was set as following: first, at all the transversal sections (b = 0 s/mm2) showing the appearance of the tumor, circular or oval ROI was adopted if the shape of tumor was regular, and manual delineated ROI was adopted to include the entire tumor if the shape of tumor was irregular; second, EADC and ADC values of each level were measured and the average value was regarded as EADC and ADC values for the whole tumor. Then the parenchymal part and cystic part of tumor were outlined at multiple levels and the mean values of EADC and ADC were obtained (Fig. 1). For tumors rich in fatty tissue, in addition to the above methods, the fatty part and non-fatty part of tumor were outlined respectively to obtain the their each mean value. For cystic lesions, ROI included the cystic wall as much as possible. There are no units of measurement for EADC value. Data were mean values averaged from two measurements.Fig. 1

Bottom Line: We found renal cell carcinoma (RCC) can be distinguished from angiomyolipoma, and clear cell carcinoma can be distinguished from non-clear cell carcinoma by EADC value.In conclusion, EADC map shows the internal structure of the kidney tumor more intuitively than the ADC map dose, and is also in line with the observation habits of the clinicians.EADC can be used as an effective imaging method for tumor diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Imaging, First Affiliated Hospital, Medicine School of Xi'an Jiaotong University, Xi'an, 710061 Shaanxi People's Republic of China.

ABSTRACT
Exponential apparent diffusion coefficient (EADC) is an indicator of diffusion-weighted imaging (DWI) and reflects the pathological changes of tissues quantitatively. However, no study has been investigated in the space-occupying kidney disease using EADC values. This study aims to evaluate the diagnostic role of EADC values at a high magnetic field strength (3.0 T) in kidney neoplastic lesions, compared with that of the ADC values. Ninety patients with suspected renal tumors (including 101 suspected renal lesions) and 20 healthy volunteers were performed MRI scanning. Diffusion-weighted imaging was performed with a single-shot spin-echo echo-planar imaging (SE-EPI) sequence at a diffusion gradient of b = 500 s/mm(2). We found renal cell carcinoma (RCC) can be distinguished from angiomyolipoma, and clear cell carcinoma can be distinguished from non-clear cell carcinoma by EADC value. There was significant difference in overall EADC values between renal cell carcinoma (0.150 ± 0.059) and angiomyolipoma (0.270 ± 0.108) when b value was 500 s/mm(2). When receiver operating characteristic (ROC) was higher than 0.192, the sensitivity and specificity of EADC value of renal cell carcinoma were 84.6 and 81.1 %, respectively. In conclusion, EADC map shows the internal structure of the kidney tumor more intuitively than the ADC map dose, and is also in line with the observation habits of the clinicians. EADC can be used as an effective imaging method for tumor diagnosis.

No MeSH data available.


Related in: MedlinePlus