Limits...
Protective effects of salidroside on epirubicin-induced early left ventricular regional systolic dysfunction in patients with breast cancer.

Zhang H, Shen WS, Gao CH, Deng LC, Shen D - Drugs R D (2012)

Bottom Line: A decline of the SR peak was observed at an epirubicin dose of 200 mg/m2, with no significant differences between salidroside and placebo (1.35 ± 0.36 vs 1.42 ± 0.49/second).At growing cumulative doses of epirubicin, the SR normalized only with salidroside, showing a significant difference in comparison with placebo at epirubicin doses of 300 mg/m2 (1.67 ± 0.43 vs 1.32 ± 0.53/second, p < 0.05) and 400 mg/m2 (1.68 ± 0.29 vs 1.40 ± 0.23/second, p < 0.05).Moreover, a significant increase in plasma concentrations of ROS was found with placebo, but they remained unchanged with salidroside.

View Article: PubMed Central - PubMed

Affiliation: Department of Echocardiography, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, Peoples Republic of China.

ABSTRACT

Background: Salidroside [2-(4-hydroxyphenyl)ethyl-β-D-glucopyranoside], one of the most potent ingredients extracted from the plant Rhodiola rosea L., has been shown to have a cardiovascular protective effect as an antioxidant, and early treatment of epirubicin-induced cardiotoxicity has been the focus of clinical chemotherapy in patients with breast cancer. However, the cardioprotective effects of salidroside on epirubicin-induced cardiotoxicity, especially early left ventricular regional systolic dysfunction, have to date been sparsely investigated.

Objective: The aim of this study was to investigate the protective effects of salidroside in preventing early left ventricular regional systolic dysfunction induced by epirubicin.

Methods: Sixty patients with histologically confirmed breast cancer were enrolled. Eligible patients were randomized to receive salidroside (600 mg/day; n = 30) or placebo (n = 30) starting 1 week before chemotherapy. Patients were investigated by means of echocardiography and strain rate (SR) imaging. We also measured plasma concentrations of reactive oxygen species (ROS). All parameters were assessed at baseline and 7 days after each new epirubicin dose of 100 mg/m2.

Results: A decline of the SR peak was observed at an epirubicin dose of 200 mg/m2, with no significant differences between salidroside and placebo (1.35 ± 0.36 vs 1.42 ± 0.49/second). At growing cumulative doses of epirubicin, the SR normalized only with salidroside, showing a significant difference in comparison with placebo at epirubicin doses of 300 mg/m2 (1.67 ± 0.43 vs 1.32 ± 0.53/second, p < 0.05) and 400 mg/m2 (1.68 ± 0.29 vs 1.40 ± 0.23/second, p < 0.05). Moreover, a significant increase in plasma concentrations of ROS was found with placebo, but they remained unchanged with salidroside.

Conclusion: Salidroside can provide a protective effect on epirubicin-induced early left ventricular regional systolic dysfunction in patients with breast cancer.

Show MeSH

Related in: MedlinePlus

Serum concentrations of reactive oxygen species in the two groupsa
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3585960&req=5

Tab3: Serum concentrations of reactive oxygen species in the two groupsa

Mentions: No significant abnormalities of the LVEF were found in either of the two groups throughout the entire treatment period (table II). However, we observed a reduction in the SR peak at t2 (p < 0.05) at an epirubicin dose of 200 mg/m2, with no significant differences between the salidroside and placebo groups (1.35 ± 0.36 vs 1.42 ± 0.49/second, p > 0.05). With growing cumulative doses of epirubicin, the SR normalized only in the salidroside group, showing a significant difference in comparison with the placebo group at epirubicin doses of 300 mg/m2 (1.67 ± 0.43 vs 1.32 ± 0.53/second, p < 0.05) and 400 mg/m2 (1.68 ± 0.29 vs 1.40 ± 0.23/second, p < 0.05) [table II]. Furthermore, the ROS serum concentrations significantly increased at t2 in the placebo group (498 ± 41 vs 849 ± 15 FORT-U, p < 0.05), whereas they remained unchanged in the salidroside group (498 ± 30 vs 519 ± 12 FORT-U, p > 0.05) [table III]. We randomly selected 15 patients to undertake the intra- and interobserver reproducibility of the myocardial strain, and both intra- and interobserver variability were below 13% (table IV).


Protective effects of salidroside on epirubicin-induced early left ventricular regional systolic dysfunction in patients with breast cancer.

Zhang H, Shen WS, Gao CH, Deng LC, Shen D - Drugs R D (2012)

Serum concentrations of reactive oxygen species in the two groupsa
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585960&req=5

Tab3: Serum concentrations of reactive oxygen species in the two groupsa
Mentions: No significant abnormalities of the LVEF were found in either of the two groups throughout the entire treatment period (table II). However, we observed a reduction in the SR peak at t2 (p < 0.05) at an epirubicin dose of 200 mg/m2, with no significant differences between the salidroside and placebo groups (1.35 ± 0.36 vs 1.42 ± 0.49/second, p > 0.05). With growing cumulative doses of epirubicin, the SR normalized only in the salidroside group, showing a significant difference in comparison with the placebo group at epirubicin doses of 300 mg/m2 (1.67 ± 0.43 vs 1.32 ± 0.53/second, p < 0.05) and 400 mg/m2 (1.68 ± 0.29 vs 1.40 ± 0.23/second, p < 0.05) [table II]. Furthermore, the ROS serum concentrations significantly increased at t2 in the placebo group (498 ± 41 vs 849 ± 15 FORT-U, p < 0.05), whereas they remained unchanged in the salidroside group (498 ± 30 vs 519 ± 12 FORT-U, p > 0.05) [table III]. We randomly selected 15 patients to undertake the intra- and interobserver reproducibility of the myocardial strain, and both intra- and interobserver variability were below 13% (table IV).

Bottom Line: A decline of the SR peak was observed at an epirubicin dose of 200 mg/m2, with no significant differences between salidroside and placebo (1.35 ± 0.36 vs 1.42 ± 0.49/second).At growing cumulative doses of epirubicin, the SR normalized only with salidroside, showing a significant difference in comparison with placebo at epirubicin doses of 300 mg/m2 (1.67 ± 0.43 vs 1.32 ± 0.53/second, p < 0.05) and 400 mg/m2 (1.68 ± 0.29 vs 1.40 ± 0.23/second, p < 0.05).Moreover, a significant increase in plasma concentrations of ROS was found with placebo, but they remained unchanged with salidroside.

View Article: PubMed Central - PubMed

Affiliation: Department of Echocardiography, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, Peoples Republic of China.

ABSTRACT

Background: Salidroside [2-(4-hydroxyphenyl)ethyl-β-D-glucopyranoside], one of the most potent ingredients extracted from the plant Rhodiola rosea L., has been shown to have a cardiovascular protective effect as an antioxidant, and early treatment of epirubicin-induced cardiotoxicity has been the focus of clinical chemotherapy in patients with breast cancer. However, the cardioprotective effects of salidroside on epirubicin-induced cardiotoxicity, especially early left ventricular regional systolic dysfunction, have to date been sparsely investigated.

Objective: The aim of this study was to investigate the protective effects of salidroside in preventing early left ventricular regional systolic dysfunction induced by epirubicin.

Methods: Sixty patients with histologically confirmed breast cancer were enrolled. Eligible patients were randomized to receive salidroside (600 mg/day; n = 30) or placebo (n = 30) starting 1 week before chemotherapy. Patients were investigated by means of echocardiography and strain rate (SR) imaging. We also measured plasma concentrations of reactive oxygen species (ROS). All parameters were assessed at baseline and 7 days after each new epirubicin dose of 100 mg/m2.

Results: A decline of the SR peak was observed at an epirubicin dose of 200 mg/m2, with no significant differences between salidroside and placebo (1.35 ± 0.36 vs 1.42 ± 0.49/second). At growing cumulative doses of epirubicin, the SR normalized only with salidroside, showing a significant difference in comparison with placebo at epirubicin doses of 300 mg/m2 (1.67 ± 0.43 vs 1.32 ± 0.53/second, p < 0.05) and 400 mg/m2 (1.68 ± 0.29 vs 1.40 ± 0.23/second, p < 0.05). Moreover, a significant increase in plasma concentrations of ROS was found with placebo, but they remained unchanged with salidroside.

Conclusion: Salidroside can provide a protective effect on epirubicin-induced early left ventricular regional systolic dysfunction in patients with breast cancer.

Show MeSH
Related in: MedlinePlus