Limits...
Effect of ethanol in Paclitaxel injections on the ethanol concentration in exhaled breath.

Aomori T, Makino H, Sekizuka M, Hashita T, Araki T, Iizuka K, Nakamura T, Yamamoto K - Drugs R D (2012)

Bottom Line: Since the volume of ethanol in these preparations is approximately half of the total injection volume, the potential inhibitory effects of ethanol on the central nervous system cannot be disregarded, especially considering that patients may drive immediately after administration of the medication.However, it is still advisable for patients to avoid driving after receiving paclitaxel injections.When driving cannot be avoided, patients should wait for a sufficient time after receiving the injection before driving.

View Article: PubMed Central - PubMed

Affiliation: Center for Medical Education, Gunma University Graduate School of Medicine, Maebashi, Japan.

ABSTRACT

Background: Ethanol is included in certain injectable preparations of anticancer drugs to increase their solubility. Since the volume of ethanol in these preparations is approximately half of the total injection volume, the potential inhibitory effects of ethanol on the central nervous system cannot be disregarded, especially considering that patients may drive immediately after administration of the medication. Therefore, the concentration of ethanol was examined in exhaled breath after administration of paclitaxel, an anticancer medication containing ethanol.

Methods: The ethanol concentration in exhaled breath immediately after an intravenous infusion of paclitaxel was measured in 30 patients, using a balloon-type gas detector tube. Correlations between the concentration of ethanol in exhaled breath and the total amount of ethanol administered or the intravenous infusion speed were calculated.

Results: The mean ethanol concentration in exhaled breath was 0.028 ± 0.015 mg/L. The correlation between the ethanol concentration in exhaled breath and the total dose of ethanol was weak (R2 = 0.25; p = 0.055), while the intravenous infusion speed showed a stronger positive correlation with the concentration of ethanol in the breath (R2 = 0.49; p = 0.11). The maximum concentration of ethanol measured in exhaled breath (0.06 mg/L) was equivalent to 40% of the threshold for drunk driving, as specified in the Road Traffic Act in Japan.

Conclusion: In this study, no patient had a breath ethanol concentration exceeding the legal threshold for drunk driving. However, it is still advisable for patients to avoid driving after receiving paclitaxel injections. When driving cannot be avoided, patients should wait for a sufficient time after receiving the injection before driving.

Show MeSH

Related in: MedlinePlus

Relationship between the ethanol concentration in exhaled breath and (a) the total amount of ethanol administered via the intravenous paclitaxel infusion; and (b) the speed of the paclitaxel infusion. The data-point markers represent observed data. The oblique black data lines represent the fitted curves.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3585845&req=5

Fig1: Relationship between the ethanol concentration in exhaled breath and (a) the total amount of ethanol administered via the intravenous paclitaxel infusion; and (b) the speed of the paclitaxel infusion. The data-point markers represent observed data. The oblique black data lines represent the fitted curves.

Mentions: The correlation coefficient between the total amount of ethanol administered via the intravenous infusion and the ethanol concentration in exhaled breath was weak (R2 = 0.25; p = 0.055) [figure 1a]. In contrast, the intravenous infusion speed had a relatively stronger positive correlation with the concentration of exhaled ethanol (R2 = 0.49; p = 0.11) [figure 1b].


Effect of ethanol in Paclitaxel injections on the ethanol concentration in exhaled breath.

Aomori T, Makino H, Sekizuka M, Hashita T, Araki T, Iizuka K, Nakamura T, Yamamoto K - Drugs R D (2012)

Relationship between the ethanol concentration in exhaled breath and (a) the total amount of ethanol administered via the intravenous paclitaxel infusion; and (b) the speed of the paclitaxel infusion. The data-point markers represent observed data. The oblique black data lines represent the fitted curves.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585845&req=5

Fig1: Relationship between the ethanol concentration in exhaled breath and (a) the total amount of ethanol administered via the intravenous paclitaxel infusion; and (b) the speed of the paclitaxel infusion. The data-point markers represent observed data. The oblique black data lines represent the fitted curves.
Mentions: The correlation coefficient between the total amount of ethanol administered via the intravenous infusion and the ethanol concentration in exhaled breath was weak (R2 = 0.25; p = 0.055) [figure 1a]. In contrast, the intravenous infusion speed had a relatively stronger positive correlation with the concentration of exhaled ethanol (R2 = 0.49; p = 0.11) [figure 1b].

Bottom Line: Since the volume of ethanol in these preparations is approximately half of the total injection volume, the potential inhibitory effects of ethanol on the central nervous system cannot be disregarded, especially considering that patients may drive immediately after administration of the medication.However, it is still advisable for patients to avoid driving after receiving paclitaxel injections.When driving cannot be avoided, patients should wait for a sufficient time after receiving the injection before driving.

View Article: PubMed Central - PubMed

Affiliation: Center for Medical Education, Gunma University Graduate School of Medicine, Maebashi, Japan.

ABSTRACT

Background: Ethanol is included in certain injectable preparations of anticancer drugs to increase their solubility. Since the volume of ethanol in these preparations is approximately half of the total injection volume, the potential inhibitory effects of ethanol on the central nervous system cannot be disregarded, especially considering that patients may drive immediately after administration of the medication. Therefore, the concentration of ethanol was examined in exhaled breath after administration of paclitaxel, an anticancer medication containing ethanol.

Methods: The ethanol concentration in exhaled breath immediately after an intravenous infusion of paclitaxel was measured in 30 patients, using a balloon-type gas detector tube. Correlations between the concentration of ethanol in exhaled breath and the total amount of ethanol administered or the intravenous infusion speed were calculated.

Results: The mean ethanol concentration in exhaled breath was 0.028 ± 0.015 mg/L. The correlation between the ethanol concentration in exhaled breath and the total dose of ethanol was weak (R2 = 0.25; p = 0.055), while the intravenous infusion speed showed a stronger positive correlation with the concentration of ethanol in the breath (R2 = 0.49; p = 0.11). The maximum concentration of ethanol measured in exhaled breath (0.06 mg/L) was equivalent to 40% of the threshold for drunk driving, as specified in the Road Traffic Act in Japan.

Conclusion: In this study, no patient had a breath ethanol concentration exceeding the legal threshold for drunk driving. However, it is still advisable for patients to avoid driving after receiving paclitaxel injections. When driving cannot be avoided, patients should wait for a sufficient time after receiving the injection before driving.

Show MeSH
Related in: MedlinePlus