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The effects of a small dose of dexamethasone on cell adhesion molecules during laparoscopic cholecystectomy.

Ionescu D, Margarit S, Hadade A, Mocan T, Cristea V, Szederjesi J - Drugs R D (2011)

Bottom Line: Both sICAM-1 and sVCAM-1 remained increased compared with baseline at 24 hours in the C group.This may partially explain the postoperative anti-inflammatory effects of dexamethasone.Further studies are needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesia and Intensive Care, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

ABSTRACT

Background and objective: There are only a few publications on the effects of dexamethasone on the plasma levels of cell adhesion molecules (CAMs). The goal of this study was to investigate the effects of dexamethasone 4 mg on the perioperative plasma levels of CAMs (soluble intercellular adhesion molecules [sICAM-1] and soluble vascular cell adhesion molecules [sVCAM-1]) during laparoscopic cholecystectomy.

Methods: Forty-two patients undergoing laparoscopic cholecystectomy under total intravenous anesthesia were enrolled and randomly divided into two groups: the first group received dexamethasone 4 mg (DEX group, n = 21) and the second group were controls (C group, n = 21). Plasma levels of sICAM-1 and sVCAM-1 were assessed before anesthesia, after induction (before surgery), and at 2 and 24 hours after surgery, respectively. Comparisons were performed for area under the plasma concentration-time curve (AUC) and within-group values.

Results: AUC comparison for sICAM-1 showed significantly increased levels in the C group (p = 0.036), while there was no significant difference for sVCAM-1 (p = 0.052). Within-group analysis showed increased levels for both sICAM-1 and sVCAM-1 in the C group at 24 hours postoperatively (p = 0.35 and p = 0.025, respectively).

Conclusions: In our study, dexamethasone 4 mg given before laparoscopic cholecystectomy determined a significant decrease in plasma levels of sICAM-1. Both sICAM-1 and sVCAM-1 remained increased compared with baseline at 24 hours in the C group. This may partially explain the postoperative anti-inflammatory effects of dexamethasone. Further studies are needed.

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Related in: MedlinePlus

Results of between-group longitudinal comparisons of plasma levels of cell adhesion molecules (CAMs) in study groups
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Tab3: Results of between-group longitudinal comparisons of plasma levels of cell adhesion molecules (CAMs) in study groups

Mentions: Area under the plasma concentration-time curve comparison between study groups revealed significant differences for sICAM-1 (p = 0.036), with greater levels in the C group, and insignificantly greater levels for sVCAM-1 (p = 0.052), in the DEX group (see table III).


The effects of a small dose of dexamethasone on cell adhesion molecules during laparoscopic cholecystectomy.

Ionescu D, Margarit S, Hadade A, Mocan T, Cristea V, Szederjesi J - Drugs R D (2011)

Results of between-group longitudinal comparisons of plasma levels of cell adhesion molecules (CAMs) in study groups
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585831&req=5

Tab3: Results of between-group longitudinal comparisons of plasma levels of cell adhesion molecules (CAMs) in study groups
Mentions: Area under the plasma concentration-time curve comparison between study groups revealed significant differences for sICAM-1 (p = 0.036), with greater levels in the C group, and insignificantly greater levels for sVCAM-1 (p = 0.052), in the DEX group (see table III).

Bottom Line: Both sICAM-1 and sVCAM-1 remained increased compared with baseline at 24 hours in the C group.This may partially explain the postoperative anti-inflammatory effects of dexamethasone.Further studies are needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesia and Intensive Care, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

ABSTRACT

Background and objective: There are only a few publications on the effects of dexamethasone on the plasma levels of cell adhesion molecules (CAMs). The goal of this study was to investigate the effects of dexamethasone 4 mg on the perioperative plasma levels of CAMs (soluble intercellular adhesion molecules [sICAM-1] and soluble vascular cell adhesion molecules [sVCAM-1]) during laparoscopic cholecystectomy.

Methods: Forty-two patients undergoing laparoscopic cholecystectomy under total intravenous anesthesia were enrolled and randomly divided into two groups: the first group received dexamethasone 4 mg (DEX group, n = 21) and the second group were controls (C group, n = 21). Plasma levels of sICAM-1 and sVCAM-1 were assessed before anesthesia, after induction (before surgery), and at 2 and 24 hours after surgery, respectively. Comparisons were performed for area under the plasma concentration-time curve (AUC) and within-group values.

Results: AUC comparison for sICAM-1 showed significantly increased levels in the C group (p = 0.036), while there was no significant difference for sVCAM-1 (p = 0.052). Within-group analysis showed increased levels for both sICAM-1 and sVCAM-1 in the C group at 24 hours postoperatively (p = 0.35 and p = 0.025, respectively).

Conclusions: In our study, dexamethasone 4 mg given before laparoscopic cholecystectomy determined a significant decrease in plasma levels of sICAM-1. Both sICAM-1 and sVCAM-1 remained increased compared with baseline at 24 hours in the C group. This may partially explain the postoperative anti-inflammatory effects of dexamethasone. Further studies are needed.

Show MeSH
Related in: MedlinePlus