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Rationale and design of South Asian Birth Cohort (START): a Canada-India collaborative study.

Anand SS, Vasudevan A, Gupta M, Morrison K, Kurpad A, Teo KK, Srinivasan K, START Cohort Study Investigato - BMC Public Health (2013)

Bottom Line: They also undergo a provocative test to diagnose impaired glucose tolerance and gestational diabetes.At delivery, cord blood and newborn anthropometric indices (i.e. birth weight, length, head circumference and skin fold thickness) are collected.Our aim is to recruit a minimum of 750 mother-infant pairs equally divided between three divergent environments: rural India, urban India, and Canada.

View Article: PubMed Central - HTML - PubMed

Affiliation: McMaster University, 1280 Main St West MDCL 3200, L8S 4K1, Hamilton, ON, Canada. anands@mcmaster.ca

ABSTRACT

Background: People who originate from the Indian subcontinent (South Asians) suffer among the highest rates of type 2 diabetes in the world. Prior evidence suggests that metabolic risk factors develop early in life and are influenced by maternal and paternal behaviors, the intrauterine environment, and genetic factors. The South Asian Birth Cohort Study (START) will investigate the environmental and genetic basis of adiposity among 750 South Asian offspring recruited from highly divergent environments, namely, rural and urban India and urban Canada.

Methods: Detailed information on health behaviors including diet and physical activity, and blood samples for metabolic parameters and DNA are collected from pregnant women of South Asian ancestry who are free of significant chronic disease. They also undergo a provocative test to diagnose impaired glucose tolerance and gestational diabetes. At delivery, cord blood and newborn anthropometric indices (i.e. birth weight, length, head circumference and skin fold thickness) are collected. The mother and growing offspring are followed prospectively and information on the growth trajectory, adiposity and health behaviors will be collected annually up to age 3 years. Our aim is to recruit a minimum of 750 mother-infant pairs equally divided between three divergent environments: rural India, urban India, and Canada.

Summary: The START cohort will increase our understanding of the environmental and genetic determinants of adiposity and related metabolic abnormalities among South Asians living in India and Canada.

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Related in: MedlinePlus

START Enrolment and Follow-up.
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Figure 2: START Enrolment and Follow-up.

Mentions: Given the differences in health care systems and feasibility of recruitment between India and Canada, the timing of follow-up assessments will vary somewhat, although both countries will collect the baby’s 2 week body weight, and monthly weight and length which will be collected by telephone interviews or by face to face examinations. In addition both countries will conduct annual assessments of the baby and mother dyad until the baby is 3 years of age. (Figure 2) The immunization of the child will be recorded at each follow up visit. A detailed schedule outlining study visits for all three cohorts is found in Table2.


Rationale and design of South Asian Birth Cohort (START): a Canada-India collaborative study.

Anand SS, Vasudevan A, Gupta M, Morrison K, Kurpad A, Teo KK, Srinivasan K, START Cohort Study Investigato - BMC Public Health (2013)

START Enrolment and Follow-up.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3585827&req=5

Figure 2: START Enrolment and Follow-up.
Mentions: Given the differences in health care systems and feasibility of recruitment between India and Canada, the timing of follow-up assessments will vary somewhat, although both countries will collect the baby’s 2 week body weight, and monthly weight and length which will be collected by telephone interviews or by face to face examinations. In addition both countries will conduct annual assessments of the baby and mother dyad until the baby is 3 years of age. (Figure 2) The immunization of the child will be recorded at each follow up visit. A detailed schedule outlining study visits for all three cohorts is found in Table2.

Bottom Line: They also undergo a provocative test to diagnose impaired glucose tolerance and gestational diabetes.At delivery, cord blood and newborn anthropometric indices (i.e. birth weight, length, head circumference and skin fold thickness) are collected.Our aim is to recruit a minimum of 750 mother-infant pairs equally divided between three divergent environments: rural India, urban India, and Canada.

View Article: PubMed Central - HTML - PubMed

Affiliation: McMaster University, 1280 Main St West MDCL 3200, L8S 4K1, Hamilton, ON, Canada. anands@mcmaster.ca

ABSTRACT

Background: People who originate from the Indian subcontinent (South Asians) suffer among the highest rates of type 2 diabetes in the world. Prior evidence suggests that metabolic risk factors develop early in life and are influenced by maternal and paternal behaviors, the intrauterine environment, and genetic factors. The South Asian Birth Cohort Study (START) will investigate the environmental and genetic basis of adiposity among 750 South Asian offspring recruited from highly divergent environments, namely, rural and urban India and urban Canada.

Methods: Detailed information on health behaviors including diet and physical activity, and blood samples for metabolic parameters and DNA are collected from pregnant women of South Asian ancestry who are free of significant chronic disease. They also undergo a provocative test to diagnose impaired glucose tolerance and gestational diabetes. At delivery, cord blood and newborn anthropometric indices (i.e. birth weight, length, head circumference and skin fold thickness) are collected. The mother and growing offspring are followed prospectively and information on the growth trajectory, adiposity and health behaviors will be collected annually up to age 3 years. Our aim is to recruit a minimum of 750 mother-infant pairs equally divided between three divergent environments: rural India, urban India, and Canada.

Summary: The START cohort will increase our understanding of the environmental and genetic determinants of adiposity and related metabolic abnormalities among South Asians living in India and Canada.

Show MeSH
Related in: MedlinePlus