Limits...
Superficial and deep lymph node dissection for stage III cutaneous melanoma: clinical outcome and prognostic factors.

Mozzillo N, Caracò C, Marone U, Di Monta G, Crispo A, Botti G, Montella M, Ascierto PA - World J Surg Oncol (2013)

Bottom Line: Lymph node involvement was clinically evident in 84 patients and detected by sentinel node biopsy in 49 cases.The 5-year disease-free survival was significantly better for patients with superficial lymph node metastases than for patients with involvement of both superficial and deep lymph nodes (34.9% vs. 19.0%; P = 0.001).Prospective studies will clarify the issue further.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Melanoma, Sarcoma and Skin Cancer, Via Mariano Semmola, Naples 80131, Italy.

ABSTRACT

Background: The aims of this retrospective analysis were to evaluate the effect of combined superficial and deep groin dissection on disease-free and melanoma-specific survival, and to identify the most important factors for predicting the involvement of deep nodes according to clinically or microscopically detected nodal metastases.

Methods: Between January 1996 and December 2005, 133 consecutive patients with groin lymph node metastases underwent superficial and deep dissection at the National Cancer Institute, Naples. Lymph node involvement was clinically evident in 84 patients and detected by sentinel node biopsy in 49 cases.

Results: The 5-year disease-free survival was significantly better for patients with superficial lymph node metastases than for patients with involvement of both superficial and deep lymph nodes (34.9% vs. 19.0%; P = 0.001). The 5-year melanoma-specific survival was also significantly better for patients with superficial node metastases only (55.6% vs. 33.3%; P = 0.001).

Conclusions: Metastasis in the deep nodes is the strongest predictor of both disease-free and melanoma-specific survival. Deep groin dissection should be considered for all patients with groin clinical nodal involvement, but might be spared in patients with a positive sentinel node. Prospective studies will clarify the issue further.

Show MeSH

Related in: MedlinePlus

Melanoma-specific survival. According to age (A), extent of lymph node involvement (B) and number of positive lymph nodes (C). P values determined with use of log-rank test.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3585715&req=5

Figure 2: Melanoma-specific survival. According to age (A), extent of lymph node involvement (B) and number of positive lymph nodes (C). P values determined with use of log-rank test.

Mentions: There was a significant difference in 5-year melanoma-specific survival according to age, with a rate of 64.1% for patients 50 years or younger and 52.2% for patients older than 50 years (P <0.03) (Table 2 and Figure 2A).


Superficial and deep lymph node dissection for stage III cutaneous melanoma: clinical outcome and prognostic factors.

Mozzillo N, Caracò C, Marone U, Di Monta G, Crispo A, Botti G, Montella M, Ascierto PA - World J Surg Oncol (2013)

Melanoma-specific survival. According to age (A), extent of lymph node involvement (B) and number of positive lymph nodes (C). P values determined with use of log-rank test.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3585715&req=5

Figure 2: Melanoma-specific survival. According to age (A), extent of lymph node involvement (B) and number of positive lymph nodes (C). P values determined with use of log-rank test.
Mentions: There was a significant difference in 5-year melanoma-specific survival according to age, with a rate of 64.1% for patients 50 years or younger and 52.2% for patients older than 50 years (P <0.03) (Table 2 and Figure 2A).

Bottom Line: Lymph node involvement was clinically evident in 84 patients and detected by sentinel node biopsy in 49 cases.The 5-year disease-free survival was significantly better for patients with superficial lymph node metastases than for patients with involvement of both superficial and deep lymph nodes (34.9% vs. 19.0%; P = 0.001).Prospective studies will clarify the issue further.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Melanoma, Sarcoma and Skin Cancer, Via Mariano Semmola, Naples 80131, Italy.

ABSTRACT

Background: The aims of this retrospective analysis were to evaluate the effect of combined superficial and deep groin dissection on disease-free and melanoma-specific survival, and to identify the most important factors for predicting the involvement of deep nodes according to clinically or microscopically detected nodal metastases.

Methods: Between January 1996 and December 2005, 133 consecutive patients with groin lymph node metastases underwent superficial and deep dissection at the National Cancer Institute, Naples. Lymph node involvement was clinically evident in 84 patients and detected by sentinel node biopsy in 49 cases.

Results: The 5-year disease-free survival was significantly better for patients with superficial lymph node metastases than for patients with involvement of both superficial and deep lymph nodes (34.9% vs. 19.0%; P = 0.001). The 5-year melanoma-specific survival was also significantly better for patients with superficial node metastases only (55.6% vs. 33.3%; P = 0.001).

Conclusions: Metastasis in the deep nodes is the strongest predictor of both disease-free and melanoma-specific survival. Deep groin dissection should be considered for all patients with groin clinical nodal involvement, but might be spared in patients with a positive sentinel node. Prospective studies will clarify the issue further.

Show MeSH
Related in: MedlinePlus