Limits...
Decreased right temporal activation and increased interhemispheric connectivity in response to speech in preterm infants at term-equivalent age.

Naoi N, Fuchino Y, Shibata M, Niwa F, Kawai M, Konishi Y, Okanoya K, Myowa-Yamakoshi M - Front Psychol (2013)

Bottom Line: The results showed that compared with ADS, IDS increased activity in larger brain areas such as the bilateral frontotemporal, temporal, and temporoparietal regions, both in full-term and preterm infants.Preterm infants exhibited decreased activity in response to speech stimuli in the right temporal region compared with full-term infants, although the significance was low.Moreover, preterm infants exhibited increased interhemispheric connectivity compared with full-term controls, especially in the temporal and temporoparietal regions.

View Article: PubMed Central - PubMed

Affiliation: Okanoya Emotional Information Project, The Exploratory Research for Advanced Technology, Japan Agency of Science and Technology Saitama, Japan ; Graduate School of Education, Kyoto University Kyoto, Japan.

ABSTRACT
Preterm infants are at increased risk of language-related problems later in life; however, few studies have examined the effects of preterm birth on cerebral responses to speech at very early developmental stages. This study examined cerebral activation and functional connectivity in response to infant-directed speech (IDS) and adult-directed speech (ADS) in full-term neonates and preterm infants at term-equivalent age using 94-channel near-infrared spectroscopy. The results showed that compared with ADS, IDS increased activity in larger brain areas such as the bilateral frontotemporal, temporal, and temporoparietal regions, both in full-term and preterm infants. Preterm infants exhibited decreased activity in response to speech stimuli in the right temporal region compared with full-term infants, although the significance was low. Moreover, preterm infants exhibited increased interhemispheric connectivity compared with full-term controls, especially in the temporal and temporoparietal regions. These differences suggest that preterm infants may follow different developmental trajectories from those born at term owing to differences in intrauterine and extrauterine development.

No MeSH data available.


Related in: MedlinePlus

Statistical maps (F-maps) for the main effect of stimuli (top left), the main effect of group (top right), and the interaction of stimuli and group (bottom left). The F-values for each channel are color-coded as indicated by the color bar (p < 0.01, uncorrected).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3585712&req=5

Figure 3: Statistical maps (F-maps) for the main effect of stimuli (top left), the main effect of group (top right), and the interaction of stimuli and group (bottom left). The F-values for each channel are color-coded as indicated by the color bar (p < 0.01, uncorrected).

Mentions: To examine the effect of preterm birth on cerebral activation in response to speech stimuli, we performed two-way mixed ANOVA for the two measurement groups (full-term and preterm) and two stimuli conditions (IDS and ADS) for each channel. We found that the magnitude of changes in the oxy-Hb response indicated a significant main effect of stimuli condition in large brain areas, including the bilateral frontotemporal, temporal, and temporoparietal regions, at the FDR-corrected p < 0.05 level (Table 2; Figure 3), and infants exhibited significantly larger responses to IDS than ADS. The same two-way ANOVA detected no significant main effect of group or interaction on the group and stimulus condition at the FDR-corrected p < 0.05 level. Using a more liberal p < 0.01 uncorrected for multiple comparisons, we detected a statistically significant main effect of group in Channel 53 (Ch 53) in the right frontotemporal area (Table 2; Figure 3), and full-term infants exhibited significantly larger responses than preterm infants. There was also a statistically significant interaction effect between group and stimulus condition in Ch 77 in the right occipital area at the uncorrected p < 0.01 level. The post hoc Bonferroni test revealed that full-term infants exhibited significantly larger responses than did preterm infants only under the ADS condition (p = 0.044).


Decreased right temporal activation and increased interhemispheric connectivity in response to speech in preterm infants at term-equivalent age.

Naoi N, Fuchino Y, Shibata M, Niwa F, Kawai M, Konishi Y, Okanoya K, Myowa-Yamakoshi M - Front Psychol (2013)

Statistical maps (F-maps) for the main effect of stimuli (top left), the main effect of group (top right), and the interaction of stimuli and group (bottom left). The F-values for each channel are color-coded as indicated by the color bar (p < 0.01, uncorrected).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3585712&req=5

Figure 3: Statistical maps (F-maps) for the main effect of stimuli (top left), the main effect of group (top right), and the interaction of stimuli and group (bottom left). The F-values for each channel are color-coded as indicated by the color bar (p < 0.01, uncorrected).
Mentions: To examine the effect of preterm birth on cerebral activation in response to speech stimuli, we performed two-way mixed ANOVA for the two measurement groups (full-term and preterm) and two stimuli conditions (IDS and ADS) for each channel. We found that the magnitude of changes in the oxy-Hb response indicated a significant main effect of stimuli condition in large brain areas, including the bilateral frontotemporal, temporal, and temporoparietal regions, at the FDR-corrected p < 0.05 level (Table 2; Figure 3), and infants exhibited significantly larger responses to IDS than ADS. The same two-way ANOVA detected no significant main effect of group or interaction on the group and stimulus condition at the FDR-corrected p < 0.05 level. Using a more liberal p < 0.01 uncorrected for multiple comparisons, we detected a statistically significant main effect of group in Channel 53 (Ch 53) in the right frontotemporal area (Table 2; Figure 3), and full-term infants exhibited significantly larger responses than preterm infants. There was also a statistically significant interaction effect between group and stimulus condition in Ch 77 in the right occipital area at the uncorrected p < 0.01 level. The post hoc Bonferroni test revealed that full-term infants exhibited significantly larger responses than did preterm infants only under the ADS condition (p = 0.044).

Bottom Line: The results showed that compared with ADS, IDS increased activity in larger brain areas such as the bilateral frontotemporal, temporal, and temporoparietal regions, both in full-term and preterm infants.Preterm infants exhibited decreased activity in response to speech stimuli in the right temporal region compared with full-term infants, although the significance was low.Moreover, preterm infants exhibited increased interhemispheric connectivity compared with full-term controls, especially in the temporal and temporoparietal regions.

View Article: PubMed Central - PubMed

Affiliation: Okanoya Emotional Information Project, The Exploratory Research for Advanced Technology, Japan Agency of Science and Technology Saitama, Japan ; Graduate School of Education, Kyoto University Kyoto, Japan.

ABSTRACT
Preterm infants are at increased risk of language-related problems later in life; however, few studies have examined the effects of preterm birth on cerebral responses to speech at very early developmental stages. This study examined cerebral activation and functional connectivity in response to infant-directed speech (IDS) and adult-directed speech (ADS) in full-term neonates and preterm infants at term-equivalent age using 94-channel near-infrared spectroscopy. The results showed that compared with ADS, IDS increased activity in larger brain areas such as the bilateral frontotemporal, temporal, and temporoparietal regions, both in full-term and preterm infants. Preterm infants exhibited decreased activity in response to speech stimuli in the right temporal region compared with full-term infants, although the significance was low. Moreover, preterm infants exhibited increased interhemispheric connectivity compared with full-term controls, especially in the temporal and temporoparietal regions. These differences suggest that preterm infants may follow different developmental trajectories from those born at term owing to differences in intrauterine and extrauterine development.

No MeSH data available.


Related in: MedlinePlus