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Husband and wife with sarcoidosis: possible environmental factors involved.

Leli I, Salimbene I, Varone F, Fuso L, Valente S - Multidiscip Respir Med (2013)

Bottom Line: It is hypothesized that the disease derives from the interaction between single or multiple environmental factors and genetically determined host factors.They had lived up to 3 years ago in the country in a farm, in contact with organic dusts, animals such as dogs, chickens, rabbits, pigeons; now they have lived since about 3 years in an urban area where there are numerous chemical industries and stone quarries.The aim of this case report was to focus on environmental factors that might be related to the pathogenesis of the sarcoidosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pulmonary Medicine, A, Gemelli University Polyclinic, Sacro Cuore Catholic University, Largo A, Gemelli 8, Rome, 00168, Italy. leila1@hotmail.it.

ABSTRACT
Sarcoidosis is a granulomatous multisystem disorder of unclear etiology that involves any organ, most commonly the lung and the lymph nodes. It is hypothesized that the disease derives from the interaction between single or multiple environmental factors and genetically determined host factors. Multiple potential etiologic agents for sarcoidosis have been proposed without any definitive demonstration of causality.We report the case of two patients, husband (57 years old) and wife (55 years old), both suffering from sarcoidosis. They underwent a lymph node biopsy by mediastinoscopy which showed a "granulomatous epithelioid giant cell non-necrotising chronic lymphadenitis". They had lived up to 3 years ago in the country in a farm, in contact with organic dusts, animals such as dogs, chickens, rabbits, pigeons; now they have lived since about 3 years in an urban area where there are numerous chemical industries and stone quarries. The aim of this case report was to focus on environmental factors that might be related to the pathogenesis of the sarcoidosis.

No MeSH data available.


Related in: MedlinePlus

Chest CT scan of the woman showing: “a series of lung nodules distributed in all lobes”.
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Figure 1: Chest CT scan of the woman showing: “a series of lung nodules distributed in all lobes”.

Mentions: The woman, 55 years old, is a housewife and a former smoker of 1 pack/years. She underwent a hysterectomy for uterine fibromatosis, and a surgical operation for right humerus osteochondroma. She has got a herpes simplex virus type I infection. At the time of our first observation she referred in the last 2 years dry cough with little sputum, dyspnea grade II according to the American Thoracic Society (ATS) scale and mild fever. At the beginning of the symptoms she performed a chest x-ray which showed “interstitial thickening” and a microbiological sputum examination which was negative for tuberculosis and fungal infection. The general practitioner gave her a non-specific antibiotic therapy with low benefit and then a steroid therapy with improvement in symptoms. At the time of our observation, she underwent a total-body CT scan which showed “a series of lung nodules distributed in all lobes; a solid slab in the mantle of the apical segment of the left lower lobe; several small adenomegalies in the anterior mediastinum, around the trachea and below aorta artery; no evidence of effusion in the pleural cavity” in the thorax (Figure 1). The CT scan showed the “presence of enlarged lymph nodes in the following areas: celiac/pancreatic lombo-aortical, bilateral internal iliac, bilateral obturator, bilateral external iliac and bilateral inguinal” in the abdomen.


Husband and wife with sarcoidosis: possible environmental factors involved.

Leli I, Salimbene I, Varone F, Fuso L, Valente S - Multidiscip Respir Med (2013)

Chest CT scan of the woman showing: “a series of lung nodules distributed in all lobes”.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3585710&req=5

Figure 1: Chest CT scan of the woman showing: “a series of lung nodules distributed in all lobes”.
Mentions: The woman, 55 years old, is a housewife and a former smoker of 1 pack/years. She underwent a hysterectomy for uterine fibromatosis, and a surgical operation for right humerus osteochondroma. She has got a herpes simplex virus type I infection. At the time of our first observation she referred in the last 2 years dry cough with little sputum, dyspnea grade II according to the American Thoracic Society (ATS) scale and mild fever. At the beginning of the symptoms she performed a chest x-ray which showed “interstitial thickening” and a microbiological sputum examination which was negative for tuberculosis and fungal infection. The general practitioner gave her a non-specific antibiotic therapy with low benefit and then a steroid therapy with improvement in symptoms. At the time of our observation, she underwent a total-body CT scan which showed “a series of lung nodules distributed in all lobes; a solid slab in the mantle of the apical segment of the left lower lobe; several small adenomegalies in the anterior mediastinum, around the trachea and below aorta artery; no evidence of effusion in the pleural cavity” in the thorax (Figure 1). The CT scan showed the “presence of enlarged lymph nodes in the following areas: celiac/pancreatic lombo-aortical, bilateral internal iliac, bilateral obturator, bilateral external iliac and bilateral inguinal” in the abdomen.

Bottom Line: It is hypothesized that the disease derives from the interaction between single or multiple environmental factors and genetically determined host factors.They had lived up to 3 years ago in the country in a farm, in contact with organic dusts, animals such as dogs, chickens, rabbits, pigeons; now they have lived since about 3 years in an urban area where there are numerous chemical industries and stone quarries.The aim of this case report was to focus on environmental factors that might be related to the pathogenesis of the sarcoidosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pulmonary Medicine, A, Gemelli University Polyclinic, Sacro Cuore Catholic University, Largo A, Gemelli 8, Rome, 00168, Italy. leila1@hotmail.it.

ABSTRACT
Sarcoidosis is a granulomatous multisystem disorder of unclear etiology that involves any organ, most commonly the lung and the lymph nodes. It is hypothesized that the disease derives from the interaction between single or multiple environmental factors and genetically determined host factors. Multiple potential etiologic agents for sarcoidosis have been proposed without any definitive demonstration of causality.We report the case of two patients, husband (57 years old) and wife (55 years old), both suffering from sarcoidosis. They underwent a lymph node biopsy by mediastinoscopy which showed a "granulomatous epithelioid giant cell non-necrotising chronic lymphadenitis". They had lived up to 3 years ago in the country in a farm, in contact with organic dusts, animals such as dogs, chickens, rabbits, pigeons; now they have lived since about 3 years in an urban area where there are numerous chemical industries and stone quarries. The aim of this case report was to focus on environmental factors that might be related to the pathogenesis of the sarcoidosis.

No MeSH data available.


Related in: MedlinePlus