Limits...
Phylogenetic diversity and genotypic complexity of H1N1 subtype swine influenza viruses isolated in mainland China.

Liu Y, Wang J, Ji J, Chang S, Xue C, Ma J, Bi Y, Xie Q - Virol. J. (2012)

Bottom Line: Most of the strains were isolated during the period of 2008 to 2010 from Guangdong and Shandong provinces, China.The viruses of different lineage are characterized with different amino acid residues at the receptor-binding sites.Moreover, it was shown that, novel lineages and genotypes of H1N1 SIVs emerged recently in mainland China.

View Article: PubMed Central - HTML - PubMed

Affiliation: College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.

ABSTRACT

Background: After the occurrence of 2009 pandemic H1N1, close attention has been paid to the H1N1 subtype swine influenza viruses (H1N1 SIV) by scientific communities in many countries. A large-scale sequence analysis of the NCBI Influenza Virus Resource Database on H1N1 SIVs submitted primarily by scientists in China during 1992 to 2011 was performed. The aims of this study were to elucidate the genetic and evolutionary characteristics of H1N1 SIVs, to identify and unify the lineages and genetic characteristics of the H1N1 SIVs isolated in mainland China.

Results: Most of the strains were isolated during the period of 2008 to 2010 from Guangdong and Shandong provinces, China. Based on the phylogenetic and genotypic analyses, all of the H1N1 SIV strains can be classified into 8 lineages and 10 genotypes. All strains were of the characteristics of low pathogenic influenza viruses. The viruses of different lineage are characterized with different amino acid residues at the receptor-binding sites. Viruses containing PB2 genes of the classical swine, early seasonal human and recent seasonal human lineage might be more infectious to human. Some genotypes were directly related with human influenza viruses, which include strains that harbored genes derived from human influenza viruses.

Conclusions: Phylogenetic diversity and complexity existed in H1N1 SIVs isolated in mainland China. These H1N1 SIV strains were closely related to other subtype influenza viruses, especially to human influenza viruses. Moreover, it was shown that, novel lineages and genotypes of H1N1 SIVs emerged recently in mainland China. These findings provided new and essential information for further understanding of the genetic and evolutionary characteristics and monitoring the H1N1 SIVs in mainland China.

Show MeSH

Related in: MedlinePlus

The genotypes of H1N1 subtype swine influenza viruses in China mainland from 1992 to 2011. The eight gene segments (horizontal bars staring from the top) were PB2, PB1, PA, HA, NP, NA, M and NS genes, and were indicated in same color with representative viruses for each lineage.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3585526&req=5

Figure 9: The genotypes of H1N1 subtype swine influenza viruses in China mainland from 1992 to 2011. The eight gene segments (horizontal bars staring from the top) were PB2, PB1, PA, HA, NP, NA, M and NS genes, and were indicated in same color with representative viruses for each lineage.

Mentions: Taken together, on the basis of the phylogenetic analyses of all eight gene segments of H1N1 SIVs isolated from pigs in mainland China from 1992 to 2011, the viruses in the present study could be divided into 10 genotypes, which were shown in Figure 9. The genetic composition of the genotypes of CS, EA, 2009H, RSH, and ESH series contained the same segments origin respectively. Of these genotypes CS-H3N2H, EA-H9N2A, EA-TR, 2009H-EA, and TR-EA included the distinct gene sources.


Phylogenetic diversity and genotypic complexity of H1N1 subtype swine influenza viruses isolated in mainland China.

Liu Y, Wang J, Ji J, Chang S, Xue C, Ma J, Bi Y, Xie Q - Virol. J. (2012)

The genotypes of H1N1 subtype swine influenza viruses in China mainland from 1992 to 2011. The eight gene segments (horizontal bars staring from the top) were PB2, PB1, PA, HA, NP, NA, M and NS genes, and were indicated in same color with representative viruses for each lineage.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3585526&req=5

Figure 9: The genotypes of H1N1 subtype swine influenza viruses in China mainland from 1992 to 2011. The eight gene segments (horizontal bars staring from the top) were PB2, PB1, PA, HA, NP, NA, M and NS genes, and were indicated in same color with representative viruses for each lineage.
Mentions: Taken together, on the basis of the phylogenetic analyses of all eight gene segments of H1N1 SIVs isolated from pigs in mainland China from 1992 to 2011, the viruses in the present study could be divided into 10 genotypes, which were shown in Figure 9. The genetic composition of the genotypes of CS, EA, 2009H, RSH, and ESH series contained the same segments origin respectively. Of these genotypes CS-H3N2H, EA-H9N2A, EA-TR, 2009H-EA, and TR-EA included the distinct gene sources.

Bottom Line: Most of the strains were isolated during the period of 2008 to 2010 from Guangdong and Shandong provinces, China.The viruses of different lineage are characterized with different amino acid residues at the receptor-binding sites.Moreover, it was shown that, novel lineages and genotypes of H1N1 SIVs emerged recently in mainland China.

View Article: PubMed Central - HTML - PubMed

Affiliation: College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.

ABSTRACT

Background: After the occurrence of 2009 pandemic H1N1, close attention has been paid to the H1N1 subtype swine influenza viruses (H1N1 SIV) by scientific communities in many countries. A large-scale sequence analysis of the NCBI Influenza Virus Resource Database on H1N1 SIVs submitted primarily by scientists in China during 1992 to 2011 was performed. The aims of this study were to elucidate the genetic and evolutionary characteristics of H1N1 SIVs, to identify and unify the lineages and genetic characteristics of the H1N1 SIVs isolated in mainland China.

Results: Most of the strains were isolated during the period of 2008 to 2010 from Guangdong and Shandong provinces, China. Based on the phylogenetic and genotypic analyses, all of the H1N1 SIV strains can be classified into 8 lineages and 10 genotypes. All strains were of the characteristics of low pathogenic influenza viruses. The viruses of different lineage are characterized with different amino acid residues at the receptor-binding sites. Viruses containing PB2 genes of the classical swine, early seasonal human and recent seasonal human lineage might be more infectious to human. Some genotypes were directly related with human influenza viruses, which include strains that harbored genes derived from human influenza viruses.

Conclusions: Phylogenetic diversity and complexity existed in H1N1 SIVs isolated in mainland China. These H1N1 SIV strains were closely related to other subtype influenza viruses, especially to human influenza viruses. Moreover, it was shown that, novel lineages and genotypes of H1N1 SIVs emerged recently in mainland China. These findings provided new and essential information for further understanding of the genetic and evolutionary characteristics and monitoring the H1N1 SIVs in mainland China.

Show MeSH
Related in: MedlinePlus