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Effects of APOA5 -1131T>C (rs662799) on fasting plasma lipids and risk of metabolic syndrome: evidence from a case-control study in China and a meta-analysis.

Xu C, Bai R, Zhang D, Li Z, Zhu H, Lai M, Zhu Y - PLoS ONE (2013)

Bottom Line: The -1131C allele was also found to be significantly associated with increased risk of MetS (OR  =  1.40, 95% confidence interval (CI)  =  1.15, 1.69) compared to the TT homozygotes.In the meta-analysis of 51,868 participants from 46 East Asian studies, 26 European studies and 19 studies of other ethnic groups, the -1131C allele was associated with higher fasting TC (weighted mean difference (WMD)  =  0.08 mmol/L, 95% CI  =  0.05, 0.10, P = 1.74×10(-9)), TG (WMD  =  0.30 mmol/L, 95% CI  =  0.26, 0.33, P =  1.87×10(-55)), LDL-cholesterol (LDL-C) (WMD  =  0.04 mmol/L, 95% CI  =  0.02, 0.07, P = 0.002), and lower HDL-C (WMD  =  -0.05 mmol/L, 95% CI  =  -0.06,-0.04, P = 1.88×10(-21)), respectively.In conclusion, the -1131C allele may be associated with elevated levels of fasting TG, TC, LDL-C and decreased HDL-C, and increased risk of MetS, especially in East Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology & Biostatistics, School of Public Health, Zhejiang University, Hangzhou, Zhejiang, PR China.

ABSTRACT
The apolipoprotein A5 (APOA5) gene -1131T>C (rs662799) has been suggested to be involved in the pathway of lipid homeostasis and the development of metabolic syndrome (MetS). However, the findings are not consistent. To systematically evaluate the associations between -1131T>C polymorphism and fasting lipid parameters and the risk of MetS, we conducted a case-control study in a Chinese population and a meta-analysis. The findings from 1840 Chinese participants indicated that the C allele carriers had significantly higher fasting total cholesterol (TC), triglycerides (TG) and lower HDL-cholesterol (HDL-C) than the TT homozygotes carriers. The -1131C allele was also found to be significantly associated with increased risk of MetS (OR  =  1.40, 95% confidence interval (CI)  =  1.15, 1.69) compared to the TT homozygotes. In the meta-analysis of 51,868 participants from 46 East Asian studies, 26 European studies and 19 studies of other ethnic groups, the -1131C allele was associated with higher fasting TC (weighted mean difference (WMD)  =  0.08 mmol/L, 95% CI  =  0.05, 0.10, P = 1.74×10(-9)), TG (WMD  =  0.30 mmol/L, 95% CI  =  0.26, 0.33, P =  1.87×10(-55)), LDL-cholesterol (LDL-C) (WMD  =  0.04 mmol/L, 95% CI  =  0.02, 0.07, P = 0.002), and lower HDL-C (WMD  =  -0.05 mmol/L, 95% CI  =  -0.06,-0.04, P = 1.88×10(-21)), respectively. Based on 12 studies with 5,573 MetS cases and 8,290 controls from 5 East Asian studies, 5 European studies and 2 studies of other ethnic groups, the -1131C allele was associated with increased risk of MetS with an OR (95% CI)  =  1.33 (1.16, 1.53) in the overall population, 1.43 (1.29, 1.58) in East Asian and 1.30 (0.94, 1.78) in European populations. In conclusion, the -1131C allele may be associated with elevated levels of fasting TG, TC, LDL-C and decreased HDL-C, and increased risk of MetS, especially in East Asians.

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Forest plot of odds ratio (OR) and 95% confidence interval (CI) for each study of the association between the −1131T>C polymorphism and metabolic syndrome risk under dominant model (carriers vs. non-carriers) in meta-analysis.The squares and horizontal lines correspond to OR and 95% CI for each study, and the area of squares reflects study weight (inverse of the variance). The diamond represents the pooled OR and its 95% CI.
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pone-0056216-g001: Forest plot of odds ratio (OR) and 95% confidence interval (CI) for each study of the association between the −1131T>C polymorphism and metabolic syndrome risk under dominant model (carriers vs. non-carriers) in meta-analysis.The squares and horizontal lines correspond to OR and 95% CI for each study, and the area of squares reflects study weight (inverse of the variance). The diamond represents the pooled OR and its 95% CI.

Mentions: A significant association was observed between the −1131T>C polymorphism and MetS under dominant model (CC+TC vs. TT): pooled OR =  1.33, 95% CI  =  1.16, 1.53, P =  0.00004 (Table 4). Similar results were found after excluding a study not in HWE. Forest plot on the basis of all available studies is shown in Figure 1. In the subgroup analysis by ethnicity of study population, significant association between the C allele and MetS risk was only detected in East Asians: pooled OR  =  1.43, 95% CI  =  1.29, 1.58, P =  2.5×10−12. However, this significance was not detected in European populations, pooled OR (95% CI): 1.30 (0.94, 1.78). When stratifying by study design, significant association was detected in both population-based (pooled OR  =  1.23, 95% CI = 1.13, 1.35) and hospital-based studies (pooled OR  =  1.70, 95% CI  =  1.44, 2.01) (Table S4).


Effects of APOA5 -1131T>C (rs662799) on fasting plasma lipids and risk of metabolic syndrome: evidence from a case-control study in China and a meta-analysis.

Xu C, Bai R, Zhang D, Li Z, Zhu H, Lai M, Zhu Y - PLoS ONE (2013)

Forest plot of odds ratio (OR) and 95% confidence interval (CI) for each study of the association between the −1131T>C polymorphism and metabolic syndrome risk under dominant model (carriers vs. non-carriers) in meta-analysis.The squares and horizontal lines correspond to OR and 95% CI for each study, and the area of squares reflects study weight (inverse of the variance). The diamond represents the pooled OR and its 95% CI.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585417&req=5

pone-0056216-g001: Forest plot of odds ratio (OR) and 95% confidence interval (CI) for each study of the association between the −1131T>C polymorphism and metabolic syndrome risk under dominant model (carriers vs. non-carriers) in meta-analysis.The squares and horizontal lines correspond to OR and 95% CI for each study, and the area of squares reflects study weight (inverse of the variance). The diamond represents the pooled OR and its 95% CI.
Mentions: A significant association was observed between the −1131T>C polymorphism and MetS under dominant model (CC+TC vs. TT): pooled OR =  1.33, 95% CI  =  1.16, 1.53, P =  0.00004 (Table 4). Similar results were found after excluding a study not in HWE. Forest plot on the basis of all available studies is shown in Figure 1. In the subgroup analysis by ethnicity of study population, significant association between the C allele and MetS risk was only detected in East Asians: pooled OR  =  1.43, 95% CI  =  1.29, 1.58, P =  2.5×10−12. However, this significance was not detected in European populations, pooled OR (95% CI): 1.30 (0.94, 1.78). When stratifying by study design, significant association was detected in both population-based (pooled OR  =  1.23, 95% CI = 1.13, 1.35) and hospital-based studies (pooled OR  =  1.70, 95% CI  =  1.44, 2.01) (Table S4).

Bottom Line: The -1131C allele was also found to be significantly associated with increased risk of MetS (OR  =  1.40, 95% confidence interval (CI)  =  1.15, 1.69) compared to the TT homozygotes.In the meta-analysis of 51,868 participants from 46 East Asian studies, 26 European studies and 19 studies of other ethnic groups, the -1131C allele was associated with higher fasting TC (weighted mean difference (WMD)  =  0.08 mmol/L, 95% CI  =  0.05, 0.10, P = 1.74×10(-9)), TG (WMD  =  0.30 mmol/L, 95% CI  =  0.26, 0.33, P =  1.87×10(-55)), LDL-cholesterol (LDL-C) (WMD  =  0.04 mmol/L, 95% CI  =  0.02, 0.07, P = 0.002), and lower HDL-C (WMD  =  -0.05 mmol/L, 95% CI  =  -0.06,-0.04, P = 1.88×10(-21)), respectively.In conclusion, the -1131C allele may be associated with elevated levels of fasting TG, TC, LDL-C and decreased HDL-C, and increased risk of MetS, especially in East Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology & Biostatistics, School of Public Health, Zhejiang University, Hangzhou, Zhejiang, PR China.

ABSTRACT
The apolipoprotein A5 (APOA5) gene -1131T>C (rs662799) has been suggested to be involved in the pathway of lipid homeostasis and the development of metabolic syndrome (MetS). However, the findings are not consistent. To systematically evaluate the associations between -1131T>C polymorphism and fasting lipid parameters and the risk of MetS, we conducted a case-control study in a Chinese population and a meta-analysis. The findings from 1840 Chinese participants indicated that the C allele carriers had significantly higher fasting total cholesterol (TC), triglycerides (TG) and lower HDL-cholesterol (HDL-C) than the TT homozygotes carriers. The -1131C allele was also found to be significantly associated with increased risk of MetS (OR  =  1.40, 95% confidence interval (CI)  =  1.15, 1.69) compared to the TT homozygotes. In the meta-analysis of 51,868 participants from 46 East Asian studies, 26 European studies and 19 studies of other ethnic groups, the -1131C allele was associated with higher fasting TC (weighted mean difference (WMD)  =  0.08 mmol/L, 95% CI  =  0.05, 0.10, P = 1.74×10(-9)), TG (WMD  =  0.30 mmol/L, 95% CI  =  0.26, 0.33, P =  1.87×10(-55)), LDL-cholesterol (LDL-C) (WMD  =  0.04 mmol/L, 95% CI  =  0.02, 0.07, P = 0.002), and lower HDL-C (WMD  =  -0.05 mmol/L, 95% CI  =  -0.06,-0.04, P = 1.88×10(-21)), respectively. Based on 12 studies with 5,573 MetS cases and 8,290 controls from 5 East Asian studies, 5 European studies and 2 studies of other ethnic groups, the -1131C allele was associated with increased risk of MetS with an OR (95% CI)  =  1.33 (1.16, 1.53) in the overall population, 1.43 (1.29, 1.58) in East Asian and 1.30 (0.94, 1.78) in European populations. In conclusion, the -1131C allele may be associated with elevated levels of fasting TG, TC, LDL-C and decreased HDL-C, and increased risk of MetS, especially in East Asians.

Show MeSH
Related in: MedlinePlus