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Distinct clinical and experimental characteristics in the patients younger than 60 years old with myelodysplastic syndromes.

Li X, Xiao ZJ, Chang CK, Xu F, Wu LY, He Q, Xu ZF, Song LX, Zhang Z, Zhou LY, Su JY, Zhang X, Guo J - PLoS ONE (2013)

Bottom Line: However, MDS is commonly found in young individuals (<60 years) in Asia.Obvious amplification of T cells and low CFU formation could be found in the younger patients.CFU formation was significantly increased in the younger patients after the removal of activated T cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, The Sixth Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China. lixiao3326@yahoo.com.cn

ABSTRACT
Myelodysplastic syndromes (MDS) mainly occur in elderly individuals in Western countries. However, MDS is commonly found in young individuals (<60 years) in Asia. The reason for the high incidence in younger individuals is still unclear, and the differences in disease features between young and elderly patients with MDS have been not well recognized. To explore these issues, in this study, we analyzed the clinical and experimental characteristics of MDS in the patients younger and older than 60 years old and characterized the potential age-associated differences. The results showed that over half of the patients with MDS (61.9%) were younger than 60 years old upon the first diagnosis. The younger patients were more likely to be female, who have lower risk and less advanced MDS. The occurrence of trisomy 8 and bone marrow failure were more frequent in the younger patients than the older ones. The marrow CD34+ cells in the younger patients showed lower proliferation and higher apoptosis in comparison with that in the older ones. Obvious amplification of T cells and low CFU formation could be found in the younger patients. CFU formation was significantly increased in the younger patients after the removal of activated T cells. In addition, the younger patients had a lower frequency of p15(INK4B) methylation, longer survival expectancy and less AML transformation. In summary, the younger patients with MDS in China may show more benign disease features than the older ones. Enhanced immunological response may be involved in the pathogenesis of MDS in the patients younger than 60 years.

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Related in: MedlinePlus

Comparison analysis in BM lymphocytes between the younger and older patients with MDS patients.Compared with the older patients with MDS, the younger ones showed higher percentage of total T cells (CD3+ cells) (A) and CD8+ T cells (B) (P = 0.067; P = 0.038). However, the older patients showed higher percentage of CD8+ Tc1 cells (CD8+IFN-γ+ cells) (C) and NK cells (CD16+ or 56+ cells) (D) than the younger ones (P = 0.001; P = 0.001).
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pone-0057392-g002: Comparison analysis in BM lymphocytes between the younger and older patients with MDS patients.Compared with the older patients with MDS, the younger ones showed higher percentage of total T cells (CD3+ cells) (A) and CD8+ T cells (B) (P = 0.067; P = 0.038). However, the older patients showed higher percentage of CD8+ Tc1 cells (CD8+IFN-γ+ cells) (C) and NK cells (CD16+ or 56+ cells) (D) than the younger ones (P = 0.001; P = 0.001).

Mentions: Among the 382 patients with lymphocyte immunophenotyping analysis available, 236 younger patients and 146 older ones were determined for lymphocyte immunophenotypes (Table 2). The percentage of total T cells (CD3+T cells) was slightly higher in the younger patients than the older ones, but the difference was not statistically significant (69% VS 63%, P = 0.067) (Figure 2A). The percentage of cytotoxic T cells (CD8+T cells) was significantly higher in the younger patients than the older ones (34% VS 29%, P = 0.038) (Figure 2B). However, the percentage of Tc1 cells and NK cells were higher in the older patients than the younger ones (37.8% VS 25.6%, P = 0.001; 14% VS 10%, P = 0.001) (Figure 2C and 2D). The percentage of helpful T cells, Th1, Th2, Tc2 and B cells were not significantly different between the younger patients and older patients (Table 2).


Distinct clinical and experimental characteristics in the patients younger than 60 years old with myelodysplastic syndromes.

Li X, Xiao ZJ, Chang CK, Xu F, Wu LY, He Q, Xu ZF, Song LX, Zhang Z, Zhou LY, Su JY, Zhang X, Guo J - PLoS ONE (2013)

Comparison analysis in BM lymphocytes between the younger and older patients with MDS patients.Compared with the older patients with MDS, the younger ones showed higher percentage of total T cells (CD3+ cells) (A) and CD8+ T cells (B) (P = 0.067; P = 0.038). However, the older patients showed higher percentage of CD8+ Tc1 cells (CD8+IFN-γ+ cells) (C) and NK cells (CD16+ or 56+ cells) (D) than the younger ones (P = 0.001; P = 0.001).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585386&req=5

pone-0057392-g002: Comparison analysis in BM lymphocytes between the younger and older patients with MDS patients.Compared with the older patients with MDS, the younger ones showed higher percentage of total T cells (CD3+ cells) (A) and CD8+ T cells (B) (P = 0.067; P = 0.038). However, the older patients showed higher percentage of CD8+ Tc1 cells (CD8+IFN-γ+ cells) (C) and NK cells (CD16+ or 56+ cells) (D) than the younger ones (P = 0.001; P = 0.001).
Mentions: Among the 382 patients with lymphocyte immunophenotyping analysis available, 236 younger patients and 146 older ones were determined for lymphocyte immunophenotypes (Table 2). The percentage of total T cells (CD3+T cells) was slightly higher in the younger patients than the older ones, but the difference was not statistically significant (69% VS 63%, P = 0.067) (Figure 2A). The percentage of cytotoxic T cells (CD8+T cells) was significantly higher in the younger patients than the older ones (34% VS 29%, P = 0.038) (Figure 2B). However, the percentage of Tc1 cells and NK cells were higher in the older patients than the younger ones (37.8% VS 25.6%, P = 0.001; 14% VS 10%, P = 0.001) (Figure 2C and 2D). The percentage of helpful T cells, Th1, Th2, Tc2 and B cells were not significantly different between the younger patients and older patients (Table 2).

Bottom Line: However, MDS is commonly found in young individuals (<60 years) in Asia.Obvious amplification of T cells and low CFU formation could be found in the younger patients.CFU formation was significantly increased in the younger patients after the removal of activated T cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, The Sixth Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China. lixiao3326@yahoo.com.cn

ABSTRACT
Myelodysplastic syndromes (MDS) mainly occur in elderly individuals in Western countries. However, MDS is commonly found in young individuals (<60 years) in Asia. The reason for the high incidence in younger individuals is still unclear, and the differences in disease features between young and elderly patients with MDS have been not well recognized. To explore these issues, in this study, we analyzed the clinical and experimental characteristics of MDS in the patients younger and older than 60 years old and characterized the potential age-associated differences. The results showed that over half of the patients with MDS (61.9%) were younger than 60 years old upon the first diagnosis. The younger patients were more likely to be female, who have lower risk and less advanced MDS. The occurrence of trisomy 8 and bone marrow failure were more frequent in the younger patients than the older ones. The marrow CD34+ cells in the younger patients showed lower proliferation and higher apoptosis in comparison with that in the older ones. Obvious amplification of T cells and low CFU formation could be found in the younger patients. CFU formation was significantly increased in the younger patients after the removal of activated T cells. In addition, the younger patients had a lower frequency of p15(INK4B) methylation, longer survival expectancy and less AML transformation. In summary, the younger patients with MDS in China may show more benign disease features than the older ones. Enhanced immunological response may be involved in the pathogenesis of MDS in the patients younger than 60 years.

Show MeSH
Related in: MedlinePlus