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Distinct clinical and experimental characteristics in the patients younger than 60 years old with myelodysplastic syndromes.

Li X, Xiao ZJ, Chang CK, Xu F, Wu LY, He Q, Xu ZF, Song LX, Zhang Z, Zhou LY, Su JY, Zhang X, Guo J - PLoS ONE (2013)

Bottom Line: However, MDS is commonly found in young individuals (<60 years) in Asia.Obvious amplification of T cells and low CFU formation could be found in the younger patients.CFU formation was significantly increased in the younger patients after the removal of activated T cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, The Sixth Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China. lixiao3326@yahoo.com.cn

ABSTRACT
Myelodysplastic syndromes (MDS) mainly occur in elderly individuals in Western countries. However, MDS is commonly found in young individuals (<60 years) in Asia. The reason for the high incidence in younger individuals is still unclear, and the differences in disease features between young and elderly patients with MDS have been not well recognized. To explore these issues, in this study, we analyzed the clinical and experimental characteristics of MDS in the patients younger and older than 60 years old and characterized the potential age-associated differences. The results showed that over half of the patients with MDS (61.9%) were younger than 60 years old upon the first diagnosis. The younger patients were more likely to be female, who have lower risk and less advanced MDS. The occurrence of trisomy 8 and bone marrow failure were more frequent in the younger patients than the older ones. The marrow CD34+ cells in the younger patients showed lower proliferation and higher apoptosis in comparison with that in the older ones. Obvious amplification of T cells and low CFU formation could be found in the younger patients. CFU formation was significantly increased in the younger patients after the removal of activated T cells. In addition, the younger patients had a lower frequency of p15(INK4B) methylation, longer survival expectancy and less AML transformation. In summary, the younger patients with MDS in China may show more benign disease features than the older ones. Enhanced immunological response may be involved in the pathogenesis of MDS in the patients younger than 60 years.

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Distribution of age and gender in MDS patients.Male-to-female ratio in MDS patients gradually increases from the young to the old. Similar incidence of MDS could be observed in the younger male and female patients before age 60. However, the older male patients have higher incidence of MDS compared with the older female patients.
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pone-0057392-g001: Distribution of age and gender in MDS patients.Male-to-female ratio in MDS patients gradually increases from the young to the old. Similar incidence of MDS could be observed in the younger male and female patients before age 60. However, the older male patients have higher incidence of MDS compared with the older female patients.

Mentions: As shown in Table 1, a total of 502 patients were analyzed. The male-to-female ratio was 1.37∶1, and the median age was 53 years (range, 13–89 years). 311 patients were younger than 60 years old, and the median age was 44 years (range, 13–59 years); 191 patients were older than 60 years, and the median age was 71 years (range, 60–89 years). The younger group accounted for 61.9% of all MDS patients and had a male-to-female ratio of 1.15∶1; the older group accounted for 38.1% of all patients and had a male-to-female ratio of 1.85∶1 (P = 0.011, compared with the younger group). Apparently, over half of MDS patients were younger than 60 years, and male-to-female ratio in MDS patients gradually increases from the young to the old (Figure 1).


Distinct clinical and experimental characteristics in the patients younger than 60 years old with myelodysplastic syndromes.

Li X, Xiao ZJ, Chang CK, Xu F, Wu LY, He Q, Xu ZF, Song LX, Zhang Z, Zhou LY, Su JY, Zhang X, Guo J - PLoS ONE (2013)

Distribution of age and gender in MDS patients.Male-to-female ratio in MDS patients gradually increases from the young to the old. Similar incidence of MDS could be observed in the younger male and female patients before age 60. However, the older male patients have higher incidence of MDS compared with the older female patients.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585386&req=5

pone-0057392-g001: Distribution of age and gender in MDS patients.Male-to-female ratio in MDS patients gradually increases from the young to the old. Similar incidence of MDS could be observed in the younger male and female patients before age 60. However, the older male patients have higher incidence of MDS compared with the older female patients.
Mentions: As shown in Table 1, a total of 502 patients were analyzed. The male-to-female ratio was 1.37∶1, and the median age was 53 years (range, 13–89 years). 311 patients were younger than 60 years old, and the median age was 44 years (range, 13–59 years); 191 patients were older than 60 years, and the median age was 71 years (range, 60–89 years). The younger group accounted for 61.9% of all MDS patients and had a male-to-female ratio of 1.15∶1; the older group accounted for 38.1% of all patients and had a male-to-female ratio of 1.85∶1 (P = 0.011, compared with the younger group). Apparently, over half of MDS patients were younger than 60 years, and male-to-female ratio in MDS patients gradually increases from the young to the old (Figure 1).

Bottom Line: However, MDS is commonly found in young individuals (<60 years) in Asia.Obvious amplification of T cells and low CFU formation could be found in the younger patients.CFU formation was significantly increased in the younger patients after the removal of activated T cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, The Sixth Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China. lixiao3326@yahoo.com.cn

ABSTRACT
Myelodysplastic syndromes (MDS) mainly occur in elderly individuals in Western countries. However, MDS is commonly found in young individuals (<60 years) in Asia. The reason for the high incidence in younger individuals is still unclear, and the differences in disease features between young and elderly patients with MDS have been not well recognized. To explore these issues, in this study, we analyzed the clinical and experimental characteristics of MDS in the patients younger and older than 60 years old and characterized the potential age-associated differences. The results showed that over half of the patients with MDS (61.9%) were younger than 60 years old upon the first diagnosis. The younger patients were more likely to be female, who have lower risk and less advanced MDS. The occurrence of trisomy 8 and bone marrow failure were more frequent in the younger patients than the older ones. The marrow CD34+ cells in the younger patients showed lower proliferation and higher apoptosis in comparison with that in the older ones. Obvious amplification of T cells and low CFU formation could be found in the younger patients. CFU formation was significantly increased in the younger patients after the removal of activated T cells. In addition, the younger patients had a lower frequency of p15(INK4B) methylation, longer survival expectancy and less AML transformation. In summary, the younger patients with MDS in China may show more benign disease features than the older ones. Enhanced immunological response may be involved in the pathogenesis of MDS in the patients younger than 60 years.

Show MeSH
Related in: MedlinePlus