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Metabolic factors associated with risk of renal cell carcinoma.

Häggström C, Rapp K, Stocks T, Manjer J, Bjørge T, Ulmer H, Engeland A, Almqvist M, Concin H, Selmer R, Ljungberg B, Tretli S, Nagel G, Hallmans G, Jonsson H, Stattin P - PLoS ONE (2013)

Bottom Line: Among women we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 2.21, 95% CI 1.32-3.70) and the composite score, (HR = 2.29, 95% CI 1.12-4.68).No multiplicative statistical or biological interactions between metabolic factors on risk of RCC were found.High levels of BMI, blood pressure, glucose and triglycerides among men and high BMI among women were associated with increased risk of RCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical and Perioperative sciences, Urology and Andrology, Umeå University, Umeå, Sweden. christel.haggstrom@urologi.umu.se

ABSTRACT
Previous studies have shown that obesity and hypertension are associated with increased risk of renal cell carcinoma (RCC), but less is known about the association to other metabolic factors. In the Metabolic Syndrome and Cancer project (Me-Can) data on body mass index (BMI, kg/m2), blood pressure, and circulating levels of glucose, cholesterol, and triglycerides were collected from 560,388 men and women in cohorts from Norway, Austria, and Sweden. By use of Cox proportional hazard models, hazard ratios (HR) were calculated for separate and composite metabolic exposures. During a median follow-up of 10 years, 592 men and 263 women were diagnosed with RCC. Among men, we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 1.51, 95% CI 1.13-2.03), systolic blood pressure, (HR = 3.40, 95% CI 1.91-6.06), diastolic blood pressure, (HR = 3.33, 95% CI 1.85-5.99), glucose, (HR = 3.75, 95% CI 1.46-9.68), triglycerides, (HR = 1.79, 95% CI 1.00-3.21) and a composite score of these metabolic factors, (HR = 2.68, 95% CI 1.75-4.11). Among women we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 2.21, 95% CI 1.32-3.70) and the composite score, (HR = 2.29, 95% CI 1.12-4.68). High levels of the composite score were also associated with risk of death from RCC among both men and women. No multiplicative statistical or biological interactions between metabolic factors on risk of RCC were found. High levels of BMI, blood pressure, glucose and triglycerides among men and high BMI among women were associated with increased risk of RCC.

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Related in: MedlinePlus

Restricted cubic splines by exposures in z-scores for men.P-values from likelihood ratio-test in the figures comparing the cubic spline polynomial with a linear model. Mean values for measured levels of exposure within parenthesis, calculated for subjects fasting >8 h for glucose, triglycerides and cholesterol. Values calibrated for random errors by regression calibration.
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pone-0057475-g002: Restricted cubic splines by exposures in z-scores for men.P-values from likelihood ratio-test in the figures comparing the cubic spline polynomial with a linear model. Mean values for measured levels of exposure within parenthesis, calculated for subjects fasting >8 h for glucose, triglycerides and cholesterol. Values calibrated for random errors by regression calibration.

Mentions: Trend tests over quintiles and analyses using spline models (Figure 2 and 3) indicated approximately linear associations for all metabolic factors in relation to RCC risk, which supports the use of linear models. We found no biological interaction between metabolic factors or multiplicative statistical interactions between the exposures or between exposure and smoking on risk of RCC after applying the Bonferroni correction. The absolute risks for RCC over a 20-year interval for a 40 year old man in the lowest composite score quintile was 0.18% and for a man in the highest quintile 0.34%, and corresponding risks for a man aged 60 was 0.42%, and 0.81%, respectively. For a 40 year old woman, the absolute risk of RCC were 0.10% in the lowest quintile and 0.18% in the highest quintile of the composite score, and corresponding risks for a 60 year old woman were 0.30% and 0.53%, respectively.


Metabolic factors associated with risk of renal cell carcinoma.

Häggström C, Rapp K, Stocks T, Manjer J, Bjørge T, Ulmer H, Engeland A, Almqvist M, Concin H, Selmer R, Ljungberg B, Tretli S, Nagel G, Hallmans G, Jonsson H, Stattin P - PLoS ONE (2013)

Restricted cubic splines by exposures in z-scores for men.P-values from likelihood ratio-test in the figures comparing the cubic spline polynomial with a linear model. Mean values for measured levels of exposure within parenthesis, calculated for subjects fasting >8 h for glucose, triglycerides and cholesterol. Values calibrated for random errors by regression calibration.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585341&req=5

pone-0057475-g002: Restricted cubic splines by exposures in z-scores for men.P-values from likelihood ratio-test in the figures comparing the cubic spline polynomial with a linear model. Mean values for measured levels of exposure within parenthesis, calculated for subjects fasting >8 h for glucose, triglycerides and cholesterol. Values calibrated for random errors by regression calibration.
Mentions: Trend tests over quintiles and analyses using spline models (Figure 2 and 3) indicated approximately linear associations for all metabolic factors in relation to RCC risk, which supports the use of linear models. We found no biological interaction between metabolic factors or multiplicative statistical interactions between the exposures or between exposure and smoking on risk of RCC after applying the Bonferroni correction. The absolute risks for RCC over a 20-year interval for a 40 year old man in the lowest composite score quintile was 0.18% and for a man in the highest quintile 0.34%, and corresponding risks for a man aged 60 was 0.42%, and 0.81%, respectively. For a 40 year old woman, the absolute risk of RCC were 0.10% in the lowest quintile and 0.18% in the highest quintile of the composite score, and corresponding risks for a 60 year old woman were 0.30% and 0.53%, respectively.

Bottom Line: Among women we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 2.21, 95% CI 1.32-3.70) and the composite score, (HR = 2.29, 95% CI 1.12-4.68).No multiplicative statistical or biological interactions between metabolic factors on risk of RCC were found.High levels of BMI, blood pressure, glucose and triglycerides among men and high BMI among women were associated with increased risk of RCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical and Perioperative sciences, Urology and Andrology, Umeå University, Umeå, Sweden. christel.haggstrom@urologi.umu.se

ABSTRACT
Previous studies have shown that obesity and hypertension are associated with increased risk of renal cell carcinoma (RCC), but less is known about the association to other metabolic factors. In the Metabolic Syndrome and Cancer project (Me-Can) data on body mass index (BMI, kg/m2), blood pressure, and circulating levels of glucose, cholesterol, and triglycerides were collected from 560,388 men and women in cohorts from Norway, Austria, and Sweden. By use of Cox proportional hazard models, hazard ratios (HR) were calculated for separate and composite metabolic exposures. During a median follow-up of 10 years, 592 men and 263 women were diagnosed with RCC. Among men, we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 1.51, 95% CI 1.13-2.03), systolic blood pressure, (HR = 3.40, 95% CI 1.91-6.06), diastolic blood pressure, (HR = 3.33, 95% CI 1.85-5.99), glucose, (HR = 3.75, 95% CI 1.46-9.68), triglycerides, (HR = 1.79, 95% CI 1.00-3.21) and a composite score of these metabolic factors, (HR = 2.68, 95% CI 1.75-4.11). Among women we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 2.21, 95% CI 1.32-3.70) and the composite score, (HR = 2.29, 95% CI 1.12-4.68). High levels of the composite score were also associated with risk of death from RCC among both men and women. No multiplicative statistical or biological interactions between metabolic factors on risk of RCC were found. High levels of BMI, blood pressure, glucose and triglycerides among men and high BMI among women were associated with increased risk of RCC.

Show MeSH
Related in: MedlinePlus