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Elevated soluble triggering receptor expressed on myeloid cells (sTREM)-1 levels in maternal serum during term and preterm labor.

Tency I, Verstraelen H, Saerens B, Verhasselt B, Vaneechoutte M, Degomme O, Verhelst R, Temmerman M - PLoS ONE (2013)

Bottom Line: It has been demonstrated that sTREM-1 is involved in bacterial infection as well as in non-infectious inflammatory conditions.Median sTREM-1 concentrations were significantly higher in women with PTB vs.Women with PTB had significantly higher levels of sTREM-1 compared to women at term in labor (P = 0.004).

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. inge.tency@ugent.be

ABSTRACT

Background: Infection and inflammation are important mechanisms leading to preterm birth. Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) belongs to a family of cell surface receptors that seems to play an important role in fine-tuning the immune response. It has been demonstrated that sTREM-1 is involved in bacterial infection as well as in non-infectious inflammatory conditions. Few studies have investigated serum sTREM-1 expression during preterm labor. Therefore, the purpose of this study was to assess sTREM-1 concentrations in maternal serum during term and preterm labor.

Methods: This case control study included 176 singleton pregnancies in the following groups: patients in (1) preterm labor, delivered before 34 weeks (PTB) (n = 52); (2) GA matched controls, not in labor, matched for gestational age (GA) with the PTB group (n = 52); (3) at term in labor (n = 40) and (4) at term not in labor (n = 32). sTREM-1 concentrations were determined by enzyme-linked immunoassay.

Results: sTREM-1 was detected in all serum samples. Median sTREM-1 concentrations were significantly higher in women with PTB vs. GA matched controls (367 pg/ml, interquartile range (IQR) 304-483 vs. 273 pg/ml, IQR 208-334; P<0.001) and in women at term in labor vs. at term not in labor (300 pg/ml, IQR 239-353 vs. 228 pg/ml, IQR 174-285; P<0.001). Women with PTB had significantly higher levels of sTREM-1 compared to women at term in labor (P = 0.004). Multiple regression analysis, with groups recoded as three key covariates (labor, preterm and rupture of the membranes), showed significantly higher sTREM-1 concentrations for labor (+30%, P<0.001) and preterm (+15%, P = 0.005) after adjusting for educational level, history of PTB and sample age.

Conclusions: sTREM-1 concentrations in maternal serum were elevated during spontaneous term and preterm labor and sTREM-1 levels were significantly higher in preterm labor.

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Related in: MedlinePlus

Serum sTREM-1 concentrations among groups.Median sTREM-1 concentrations are significantly elevated in women in labor (either term or preterm) vs. non-laboring controls. sTREM-1 levels are significantly higher in preterm vs. term labor. Horizontal bars denote the median value for each study group.
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pone-0056050-g001: Serum sTREM-1 concentrations among groups.Median sTREM-1 concentrations are significantly elevated in women in labor (either term or preterm) vs. non-laboring controls. sTREM-1 levels are significantly higher in preterm vs. term labor. Horizontal bars denote the median value for each study group.

Mentions: sTREM-1 was detected in all serum samples collected in this study. Figure 1 shows sTREM-1 concentrations among the different groups. Significantly higher median concentrations of sTREM-1 were seen in women with PTB compared to GA matched controls (367 pg/ml, interquartile range (IQR) 304–483 vs. 273 pg/ml, IQR 208–334; P<0.001). Median sTREM-1 concentrations were significantly increased in women AT in labor compared with AT not in labor (300 pg/ml, IQR 239–353 vs. 228 pg/ml, IQR 174–285; P<0.001). Women with PTB had significantly higher sTREM-1 levels than women AT in labor (367 pg/ml, IQR 304–483 vs. 300 pg/ml, IQR 239–353; P = 0.004) (Figure 1).


Elevated soluble triggering receptor expressed on myeloid cells (sTREM)-1 levels in maternal serum during term and preterm labor.

Tency I, Verstraelen H, Saerens B, Verhasselt B, Vaneechoutte M, Degomme O, Verhelst R, Temmerman M - PLoS ONE (2013)

Serum sTREM-1 concentrations among groups.Median sTREM-1 concentrations are significantly elevated in women in labor (either term or preterm) vs. non-laboring controls. sTREM-1 levels are significantly higher in preterm vs. term labor. Horizontal bars denote the median value for each study group.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585334&req=5

pone-0056050-g001: Serum sTREM-1 concentrations among groups.Median sTREM-1 concentrations are significantly elevated in women in labor (either term or preterm) vs. non-laboring controls. sTREM-1 levels are significantly higher in preterm vs. term labor. Horizontal bars denote the median value for each study group.
Mentions: sTREM-1 was detected in all serum samples collected in this study. Figure 1 shows sTREM-1 concentrations among the different groups. Significantly higher median concentrations of sTREM-1 were seen in women with PTB compared to GA matched controls (367 pg/ml, interquartile range (IQR) 304–483 vs. 273 pg/ml, IQR 208–334; P<0.001). Median sTREM-1 concentrations were significantly increased in women AT in labor compared with AT not in labor (300 pg/ml, IQR 239–353 vs. 228 pg/ml, IQR 174–285; P<0.001). Women with PTB had significantly higher sTREM-1 levels than women AT in labor (367 pg/ml, IQR 304–483 vs. 300 pg/ml, IQR 239–353; P = 0.004) (Figure 1).

Bottom Line: It has been demonstrated that sTREM-1 is involved in bacterial infection as well as in non-infectious inflammatory conditions.Median sTREM-1 concentrations were significantly higher in women with PTB vs.Women with PTB had significantly higher levels of sTREM-1 compared to women at term in labor (P = 0.004).

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. inge.tency@ugent.be

ABSTRACT

Background: Infection and inflammation are important mechanisms leading to preterm birth. Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) belongs to a family of cell surface receptors that seems to play an important role in fine-tuning the immune response. It has been demonstrated that sTREM-1 is involved in bacterial infection as well as in non-infectious inflammatory conditions. Few studies have investigated serum sTREM-1 expression during preterm labor. Therefore, the purpose of this study was to assess sTREM-1 concentrations in maternal serum during term and preterm labor.

Methods: This case control study included 176 singleton pregnancies in the following groups: patients in (1) preterm labor, delivered before 34 weeks (PTB) (n = 52); (2) GA matched controls, not in labor, matched for gestational age (GA) with the PTB group (n = 52); (3) at term in labor (n = 40) and (4) at term not in labor (n = 32). sTREM-1 concentrations were determined by enzyme-linked immunoassay.

Results: sTREM-1 was detected in all serum samples. Median sTREM-1 concentrations were significantly higher in women with PTB vs. GA matched controls (367 pg/ml, interquartile range (IQR) 304-483 vs. 273 pg/ml, IQR 208-334; P<0.001) and in women at term in labor vs. at term not in labor (300 pg/ml, IQR 239-353 vs. 228 pg/ml, IQR 174-285; P<0.001). Women with PTB had significantly higher levels of sTREM-1 compared to women at term in labor (P = 0.004). Multiple regression analysis, with groups recoded as three key covariates (labor, preterm and rupture of the membranes), showed significantly higher sTREM-1 concentrations for labor (+30%, P<0.001) and preterm (+15%, P = 0.005) after adjusting for educational level, history of PTB and sample age.

Conclusions: sTREM-1 concentrations in maternal serum were elevated during spontaneous term and preterm labor and sTREM-1 levels were significantly higher in preterm labor.

Show MeSH
Related in: MedlinePlus