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Effects of gender on severity, management and outcome in acute biliary pancreatitis.

Shen HN, Wang WC, Lu CL, Li CY - PLoS ONE (2013)

Bottom Line: The primary outcome was hospital mortality.After adjustment for potential confounders, men had 81% higher odds of in-hospital death than women (aOR 1.81, 95% CI 1.15-2.86).Gender is an important determinant of outcome in patients with ABP and may affect their treatment measures.

View Article: PubMed Central - PubMed

Affiliation: Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan.

ABSTRACT

Background: We conducted a population-based cross-sectional study to examine gender differences in severity, management, and outcome among patients with acute biliary pancreatitis (ABP) because available data are insufficient and conflicting.

Methods: We analyzed 13,110 patients (50.6% male) with first-attack ABP from Taiwan's National Health Insurance Research Database between 2000 and 2009. The primary outcome was hospital mortality. Secondary outcomes included the development of severe ABP and the provision of treatment measures. Gender difference was assessed using multivariable analyses with generalized estimating equations models.

Results: The odds of gastrointestinal bleeding (adjusted odds ratio [aOR] 1.44, 95% confidence interval [CI] 1.18-1.76) and local complication (aOR 1.38, 95% CI 1.05-1.82) were 44% and 38% higher in men than in women, respectively. Compared with women, men had 24% higher odds of receiving total parenteral nutrition (aOR 1.24, 95% CI 1.00-1.52), but had 18% and 41% lower odds of receiving cholecystectomy (aOR 0.82, 95% CI 0.72-0.93) and hemodialysis (aOR 0.59, 95% CI 0.42-0.83), respectively. Hospital mortality was higher in men than in women (1.8% vs. 1.1%, pā€Š=ā€Š0.001). After adjustment for potential confounders, men had 81% higher odds of in-hospital death than women (aOR 1.81, 95% CI 1.15-2.86). Among patients with severe ABP, hospital mortality was 11.0% and 7.5% in men and women (p<0.001), respectively. The adjusted odds of death remained higher in men than in women with severe ABP (aOR 1.72, 95% CI 1.10-2.68).

Conclusions: Gender is an important determinant of outcome in patients with ABP and may affect their treatment measures.

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Related in: MedlinePlus

Study flow diagram.(NHIRD: National Health Insurance Research Database).
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Related In: Results  -  Collection


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pone-0057504-g001: Study flow diagram.(NHIRD: National Health Insurance Research Database).

Mentions: Figure 1 shows the enrollment process of patients with ABP, part of which has been described in a previous study [17]. Briefly, we initially identified patients with first-attack acute pancreatitis between 2000 and 2009, and then excluded those who were less than 18 years old or had no diagnosis of cholelithiasis. Finally, we excluded patients whose diagnosis of pancreatitis was not listed in the principal diagnosis or who had a concurrent diagnosis of alcohol abuse. The remaining 13,110 patients (50.6% male) were included in the analyses.


Effects of gender on severity, management and outcome in acute biliary pancreatitis.

Shen HN, Wang WC, Lu CL, Li CY - PLoS ONE (2013)

Study flow diagram.(NHIRD: National Health Insurance Research Database).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585306&req=5

pone-0057504-g001: Study flow diagram.(NHIRD: National Health Insurance Research Database).
Mentions: Figure 1 shows the enrollment process of patients with ABP, part of which has been described in a previous study [17]. Briefly, we initially identified patients with first-attack acute pancreatitis between 2000 and 2009, and then excluded those who were less than 18 years old or had no diagnosis of cholelithiasis. Finally, we excluded patients whose diagnosis of pancreatitis was not listed in the principal diagnosis or who had a concurrent diagnosis of alcohol abuse. The remaining 13,110 patients (50.6% male) were included in the analyses.

Bottom Line: The primary outcome was hospital mortality.After adjustment for potential confounders, men had 81% higher odds of in-hospital death than women (aOR 1.81, 95% CI 1.15-2.86).Gender is an important determinant of outcome in patients with ABP and may affect their treatment measures.

View Article: PubMed Central - PubMed

Affiliation: Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan.

ABSTRACT

Background: We conducted a population-based cross-sectional study to examine gender differences in severity, management, and outcome among patients with acute biliary pancreatitis (ABP) because available data are insufficient and conflicting.

Methods: We analyzed 13,110 patients (50.6% male) with first-attack ABP from Taiwan's National Health Insurance Research Database between 2000 and 2009. The primary outcome was hospital mortality. Secondary outcomes included the development of severe ABP and the provision of treatment measures. Gender difference was assessed using multivariable analyses with generalized estimating equations models.

Results: The odds of gastrointestinal bleeding (adjusted odds ratio [aOR] 1.44, 95% confidence interval [CI] 1.18-1.76) and local complication (aOR 1.38, 95% CI 1.05-1.82) were 44% and 38% higher in men than in women, respectively. Compared with women, men had 24% higher odds of receiving total parenteral nutrition (aOR 1.24, 95% CI 1.00-1.52), but had 18% and 41% lower odds of receiving cholecystectomy (aOR 0.82, 95% CI 0.72-0.93) and hemodialysis (aOR 0.59, 95% CI 0.42-0.83), respectively. Hospital mortality was higher in men than in women (1.8% vs. 1.1%, pā€Š=ā€Š0.001). After adjustment for potential confounders, men had 81% higher odds of in-hospital death than women (aOR 1.81, 95% CI 1.15-2.86). Among patients with severe ABP, hospital mortality was 11.0% and 7.5% in men and women (p<0.001), respectively. The adjusted odds of death remained higher in men than in women with severe ABP (aOR 1.72, 95% CI 1.10-2.68).

Conclusions: Gender is an important determinant of outcome in patients with ABP and may affect their treatment measures.

Show MeSH
Related in: MedlinePlus