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Elevated chemerin levels in Pakistani men: an interrelation with metabolic syndrome phenotypes.

Fatima SS, Bozaoglu K, Rehman R, Alam F, Memon AS - PLoS ONE (2013)

Bottom Line: Circulating chemerin levels were significantly higher in obese subjects with BMI greater than 25 kg/m(2) compared with those with a BMI below 25 kg/m(2) (P = 0.001).Serum chemerin levels were found to be independently and significantly associated with serum levels of cholesterol (P = 0.0160; r = 0.255), fasting glucose (P = 0.002; r = 0.323), HOMA-IR (P = 0.004; r = 0.300) and hip circumference (P = 0.021; r = 0.246).This demonstrates that chemerin levels are associated with obesity and dyslipidemia and may play a role in the development of insulin resistance.

View Article: PubMed Central - PubMed

Affiliation: Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan. sadia.fatima@aku.edu

ABSTRACT
Chemerin is a novel protein linked to adipocyte differentiation and the development of metabolic imbalances. We sought to examine the relationship of chemerin with metabolic syndrome disturbances including body fat percentage, serum lipid, glucose, insulin levels and body fat percentage in lean and obese volunteers. A cross-sectional study of 90 randomly selected healthy males from Pakistan were divided into three groups as per Body Mass Index (BMI) criteria for South Asian Population. Anthropometric measurements were taken for BMI, waist circumference, hip circumference and body fat percentage, while serum analyses were performed for fasting blood glucose, fasting insulin, fasting lipid profile and serum chemerin. Associations between serum chemerin levels and body fat and other metabolic syndrome parameters were performed using ANOVA and multiple regression analyses. Data was presented as Mean±SD. In all statistical analyses p-values <0.05 were considered significant. Circulating chemerin levels were significantly higher in obese subjects with BMI greater than 25 kg/m(2) compared with those with a BMI below 25 kg/m(2) (P = 0.001). Serum chemerin levels were found to be independently and significantly associated with serum levels of cholesterol (P = 0.0160; r = 0.255), fasting glucose (P = 0.002; r = 0.323), HOMA-IR (P = 0.004; r = 0.300) and hip circumference (P = 0.021; r = 0.246). This demonstrates that chemerin levels are associated with obesity and dyslipidemia and may play a role in the development of insulin resistance. This data suggests that chemerin may serve as an independent marker in diagnosing these conditions even before they become clinically symptomatic.

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Related in: MedlinePlus

Box-Plot of Anthropometric Parameters of Study Groups.(A) Body fat percentage (B) Hip circumference (C) Waist circumference (D) Body mass index. Significant differences were observed in both overweight (Group B; p<0.05) and obese groups (Group C; p<0.01) compared with normal weight group (Group A; p<0.05). There were 30 subjects per group.
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pone-0057113-g001: Box-Plot of Anthropometric Parameters of Study Groups.(A) Body fat percentage (B) Hip circumference (C) Waist circumference (D) Body mass index. Significant differences were observed in both overweight (Group B; p<0.05) and obese groups (Group C; p<0.01) compared with normal weight group (Group A; p<0.05). There were 30 subjects per group.

Mentions: A total of 90 male subjects participated in this study and were divided into three groups according to BMI criteria for South Asian population [28]. Group A were subjects with normal weight (BMI = 18–22.9 kg/m2), Group B were overweight (BMI = 23–25 kg/m2), Group C were obese (BMI>25 kg/m2) subjects. All subjects were age matched and therefore no significant differences were observed between the groups. The biochemical and biophysical parameters of the subjects are outlined in Table 1 and Figure 1. Briefly, no significant changes were observed with height among all groups, but weight portrayed a strong positive correlation with serum chemerin concentrations (P<0.01; r = 0.705). Serum chemerin concentration was significantly increased in the obese group (Group C) (76.4±13.4) as compared to the normal weight group (Group A) (12.0±3.3) and overweight group (Group B) (17.2±6.1) (P = 0.001; (Figure 2). This suggests that the degree of adiposity determines the adipokine level, which in turn may be responsible for metabolic disturbances found in obesity.


Elevated chemerin levels in Pakistani men: an interrelation with metabolic syndrome phenotypes.

Fatima SS, Bozaoglu K, Rehman R, Alam F, Memon AS - PLoS ONE (2013)

Box-Plot of Anthropometric Parameters of Study Groups.(A) Body fat percentage (B) Hip circumference (C) Waist circumference (D) Body mass index. Significant differences were observed in both overweight (Group B; p<0.05) and obese groups (Group C; p<0.01) compared with normal weight group (Group A; p<0.05). There were 30 subjects per group.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585305&req=5

pone-0057113-g001: Box-Plot of Anthropometric Parameters of Study Groups.(A) Body fat percentage (B) Hip circumference (C) Waist circumference (D) Body mass index. Significant differences were observed in both overweight (Group B; p<0.05) and obese groups (Group C; p<0.01) compared with normal weight group (Group A; p<0.05). There were 30 subjects per group.
Mentions: A total of 90 male subjects participated in this study and were divided into three groups according to BMI criteria for South Asian population [28]. Group A were subjects with normal weight (BMI = 18–22.9 kg/m2), Group B were overweight (BMI = 23–25 kg/m2), Group C were obese (BMI>25 kg/m2) subjects. All subjects were age matched and therefore no significant differences were observed between the groups. The biochemical and biophysical parameters of the subjects are outlined in Table 1 and Figure 1. Briefly, no significant changes were observed with height among all groups, but weight portrayed a strong positive correlation with serum chemerin concentrations (P<0.01; r = 0.705). Serum chemerin concentration was significantly increased in the obese group (Group C) (76.4±13.4) as compared to the normal weight group (Group A) (12.0±3.3) and overweight group (Group B) (17.2±6.1) (P = 0.001; (Figure 2). This suggests that the degree of adiposity determines the adipokine level, which in turn may be responsible for metabolic disturbances found in obesity.

Bottom Line: Circulating chemerin levels were significantly higher in obese subjects with BMI greater than 25 kg/m(2) compared with those with a BMI below 25 kg/m(2) (P = 0.001).Serum chemerin levels were found to be independently and significantly associated with serum levels of cholesterol (P = 0.0160; r = 0.255), fasting glucose (P = 0.002; r = 0.323), HOMA-IR (P = 0.004; r = 0.300) and hip circumference (P = 0.021; r = 0.246).This demonstrates that chemerin levels are associated with obesity and dyslipidemia and may play a role in the development of insulin resistance.

View Article: PubMed Central - PubMed

Affiliation: Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan. sadia.fatima@aku.edu

ABSTRACT
Chemerin is a novel protein linked to adipocyte differentiation and the development of metabolic imbalances. We sought to examine the relationship of chemerin with metabolic syndrome disturbances including body fat percentage, serum lipid, glucose, insulin levels and body fat percentage in lean and obese volunteers. A cross-sectional study of 90 randomly selected healthy males from Pakistan were divided into three groups as per Body Mass Index (BMI) criteria for South Asian Population. Anthropometric measurements were taken for BMI, waist circumference, hip circumference and body fat percentage, while serum analyses were performed for fasting blood glucose, fasting insulin, fasting lipid profile and serum chemerin. Associations between serum chemerin levels and body fat and other metabolic syndrome parameters were performed using ANOVA and multiple regression analyses. Data was presented as Mean±SD. In all statistical analyses p-values <0.05 were considered significant. Circulating chemerin levels were significantly higher in obese subjects with BMI greater than 25 kg/m(2) compared with those with a BMI below 25 kg/m(2) (P = 0.001). Serum chemerin levels were found to be independently and significantly associated with serum levels of cholesterol (P = 0.0160; r = 0.255), fasting glucose (P = 0.002; r = 0.323), HOMA-IR (P = 0.004; r = 0.300) and hip circumference (P = 0.021; r = 0.246). This demonstrates that chemerin levels are associated with obesity and dyslipidemia and may play a role in the development of insulin resistance. This data suggests that chemerin may serve as an independent marker in diagnosing these conditions even before they become clinically symptomatic.

Show MeSH
Related in: MedlinePlus