Limits...
High expression of Lewis y antigen and CD44 is correlated with resistance to chemotherapy in epithelial ovarian cancers.

Hu Z, Gao J, Zhang D, Liu Q, Yan L, Gao L, Liu J, Liu D, Zhang S, Lin B - PLoS ONE (2013)

Bottom Line: The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total).The rates of expression of Lewis y antigen and CD44 antigen were significantly greater in the drug-resistant group than that in the partially-sensitive or sensitive groups.Surgical stage, residual tumor size and expression of CD44 and Lewis y antigen in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital/China Medical University, Shenyang, Liaoning Province, China.

ABSTRACT

Objectives: To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy.

Methods: The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total).

Results: The rates of expression of Lewis y antigen and CD44 antigen were significantly greater in the drug-resistant group than that in the partially-sensitive or sensitive groups. Surgical stage, residual tumor size and expression of CD44 and Lewis y antigen in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance.

Conclusions: Over-expression of Lewis y and CD44 antigen are strong risk factors for chemotherapeutic drug resistance in ovarian carcinoma patients.

Show MeSH

Related in: MedlinePlus

Kaplan-Meier curves of overall survival stratified by grouping, using cancer-related death as the endpoints (A curves of overall survival stratified by grouping, n = 92, p<0.001. B curves of deaths stratified by stage, n = 42).
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3585297&req=5

pone-0057250-g003: Kaplan-Meier curves of overall survival stratified by grouping, using cancer-related death as the endpoints (A curves of overall survival stratified by grouping, n = 92, p<0.001. B curves of deaths stratified by stage, n = 42).

Mentions: Results from follow-up revealed that 26 patients (1 stage I, 2 stage II, 23 stage III; mean age, 56.07; median age, 56) in the chemotherapy-resistant group died of ovarian cancer relapse and metastasis; 5 patients (1 stage II, 4 stage III; mean age, 64.6; median age, 63) in the partially chemotherapy-sensitive group died, and 13 patients (2 stage I, 3 stage II, 8 stage III; mean age, 54.58; median age, 54) in the chemotherapy-sensitive group died. Overall survival was significantly shorter in the chemotherapy-resistant group (p<0.001, Figure 3) compared to the sensitive groups. However, as a greater percentage of deaths in the chemotherapy resistant group were from stage III cancers, we cannot conclusively state that glycosylated Lewis y antigen and CD44 are associated with survival outcomes.


High expression of Lewis y antigen and CD44 is correlated with resistance to chemotherapy in epithelial ovarian cancers.

Hu Z, Gao J, Zhang D, Liu Q, Yan L, Gao L, Liu J, Liu D, Zhang S, Lin B - PLoS ONE (2013)

Kaplan-Meier curves of overall survival stratified by grouping, using cancer-related death as the endpoints (A curves of overall survival stratified by grouping, n = 92, p<0.001. B curves of deaths stratified by stage, n = 42).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585297&req=5

pone-0057250-g003: Kaplan-Meier curves of overall survival stratified by grouping, using cancer-related death as the endpoints (A curves of overall survival stratified by grouping, n = 92, p<0.001. B curves of deaths stratified by stage, n = 42).
Mentions: Results from follow-up revealed that 26 patients (1 stage I, 2 stage II, 23 stage III; mean age, 56.07; median age, 56) in the chemotherapy-resistant group died of ovarian cancer relapse and metastasis; 5 patients (1 stage II, 4 stage III; mean age, 64.6; median age, 63) in the partially chemotherapy-sensitive group died, and 13 patients (2 stage I, 3 stage II, 8 stage III; mean age, 54.58; median age, 54) in the chemotherapy-sensitive group died. Overall survival was significantly shorter in the chemotherapy-resistant group (p<0.001, Figure 3) compared to the sensitive groups. However, as a greater percentage of deaths in the chemotherapy resistant group were from stage III cancers, we cannot conclusively state that glycosylated Lewis y antigen and CD44 are associated with survival outcomes.

Bottom Line: The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total).The rates of expression of Lewis y antigen and CD44 antigen were significantly greater in the drug-resistant group than that in the partially-sensitive or sensitive groups.Surgical stage, residual tumor size and expression of CD44 and Lewis y antigen in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital/China Medical University, Shenyang, Liaoning Province, China.

ABSTRACT

Objectives: To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy.

Methods: The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total).

Results: The rates of expression of Lewis y antigen and CD44 antigen were significantly greater in the drug-resistant group than that in the partially-sensitive or sensitive groups. Surgical stage, residual tumor size and expression of CD44 and Lewis y antigen in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance.

Conclusions: Over-expression of Lewis y and CD44 antigen are strong risk factors for chemotherapeutic drug resistance in ovarian carcinoma patients.

Show MeSH
Related in: MedlinePlus