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High expression of Lewis y antigen and CD44 is correlated with resistance to chemotherapy in epithelial ovarian cancers.

Hu Z, Gao J, Zhang D, Liu Q, Yan L, Gao L, Liu J, Liu D, Zhang S, Lin B - PLoS ONE (2013)

Bottom Line: The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total).The rates of expression of Lewis y antigen and CD44 antigen were significantly greater in the drug-resistant group than that in the partially-sensitive or sensitive groups.Surgical stage, residual tumor size and expression of CD44 and Lewis y antigen in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital/China Medical University, Shenyang, Liaoning Province, China.

ABSTRACT

Objectives: To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy.

Methods: The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total).

Results: The rates of expression of Lewis y antigen and CD44 antigen were significantly greater in the drug-resistant group than that in the partially-sensitive or sensitive groups. Surgical stage, residual tumor size and expression of CD44 and Lewis y antigen in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance.

Conclusions: Over-expression of Lewis y and CD44 antigen are strong risk factors for chemotherapeutic drug resistance in ovarian carcinoma patients.

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Related in: MedlinePlus

The expression of Lewis y in ovarian carcinoma tissues, the molecule was present primarily in the cell membrane, but also in the cytoplasm.(A chemotherapy-resistant group; B chemotherapy-sensitive group. ×200).
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pone-0057250-g001: The expression of Lewis y in ovarian carcinoma tissues, the molecule was present primarily in the cell membrane, but also in the cytoplasm.(A chemotherapy-resistant group; B chemotherapy-sensitive group. ×200).

Mentions: Staining for Lewis y antigen revealed that the molecule was present primarily in the cell membrane, but also in the cytoplasm (Figure 1). The rates of positive expression of Lewis y antigen in the drug-resistant, partially sensitive and sensitive groups were 91.17%, 55.00% and 61.54%, respectively (Table 1). The rate of positive expression of Lewis y antigen in the drug-resistant group was significantly higher than in the partially sensitive group and sensitive group (both p<0.05). No significant difference in expression of the Lewis y antigen was observed between the partially sensitive and sensitive groups (p = 0.915).


High expression of Lewis y antigen and CD44 is correlated with resistance to chemotherapy in epithelial ovarian cancers.

Hu Z, Gao J, Zhang D, Liu Q, Yan L, Gao L, Liu J, Liu D, Zhang S, Lin B - PLoS ONE (2013)

The expression of Lewis y in ovarian carcinoma tissues, the molecule was present primarily in the cell membrane, but also in the cytoplasm.(A chemotherapy-resistant group; B chemotherapy-sensitive group. ×200).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585297&req=5

pone-0057250-g001: The expression of Lewis y in ovarian carcinoma tissues, the molecule was present primarily in the cell membrane, but also in the cytoplasm.(A chemotherapy-resistant group; B chemotherapy-sensitive group. ×200).
Mentions: Staining for Lewis y antigen revealed that the molecule was present primarily in the cell membrane, but also in the cytoplasm (Figure 1). The rates of positive expression of Lewis y antigen in the drug-resistant, partially sensitive and sensitive groups were 91.17%, 55.00% and 61.54%, respectively (Table 1). The rate of positive expression of Lewis y antigen in the drug-resistant group was significantly higher than in the partially sensitive group and sensitive group (both p<0.05). No significant difference in expression of the Lewis y antigen was observed between the partially sensitive and sensitive groups (p = 0.915).

Bottom Line: The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total).The rates of expression of Lewis y antigen and CD44 antigen were significantly greater in the drug-resistant group than that in the partially-sensitive or sensitive groups.Surgical stage, residual tumor size and expression of CD44 and Lewis y antigen in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital/China Medical University, Shenyang, Liaoning Province, China.

ABSTRACT

Objectives: To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy.

Methods: The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total).

Results: The rates of expression of Lewis y antigen and CD44 antigen were significantly greater in the drug-resistant group than that in the partially-sensitive or sensitive groups. Surgical stage, residual tumor size and expression of CD44 and Lewis y antigen in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance.

Conclusions: Over-expression of Lewis y and CD44 antigen are strong risk factors for chemotherapeutic drug resistance in ovarian carcinoma patients.

Show MeSH
Related in: MedlinePlus