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The effects of melatonin on the physical properties of bones and egg shells in the laying hen.

Taylor AC, Horvat-Gordon M, Moore A, Bartell PA - PLoS ONE (2013)

Bottom Line: Hens treated with a high concentration of melatonin showed significant strengthening in their femur and tibia, as measured by maximum force sustained and breaking force, compared to controls.Egg weights from hens treated with melatonin were significantly greater than those from hens that were not treated with melatonin.Conversely, egg shell mass of hens treated with melatonin was significantly lower than those of hens not treated with melatonin.

View Article: PubMed Central - PubMed

Affiliation: Department of Animal Science, The Pennsylvania State University, University Park, Pennsylvania, USA.

ABSTRACT
Laying hens often experience unbalanced calcium utilization which can cause deficiencies in bone and egg mineralization. Because melatonin has been shown to affect bone mineralization in other animals, we examined whether treating hens with melatonin would affect eggshell thickness and improve skeletal performance, thereby reducing skeletal and egg shell defects. Birds were given a diet containing either low (30 µg/kg), medium (300 µg/kg), or high (3 mg/kg) concentrations of melatonin, or control feed through approximately one laying cycle. We examined the weight, length, and strength of egg, femur, tibia, and keel. Hens treated with a high concentration of melatonin showed significant strengthening in their femur and tibia, as measured by maximum force sustained and breaking force, compared to controls. Egg weights from hens treated with melatonin were significantly greater than those from hens that were not treated with melatonin. Conversely, egg shell mass of hens treated with melatonin was significantly lower than those of hens not treated with melatonin. Our data suggest that melatonin may affect the allocation of calcium to bone at the expense of egg shell mineralization.

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Related in: MedlinePlus

Tibia break force was significantly greater in birds treated with high concentrations of melatonin (244.03±14.19) compared to those from birds treated with low concentrations of melatonin 203.37±11.21) or those from controls (173.00±13.21; p<0.01).Groups sharing a letter are not significantly different.
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pone-0055663-g005: Tibia break force was significantly greater in birds treated with high concentrations of melatonin (244.03±14.19) compared to those from birds treated with low concentrations of melatonin 203.37±11.21) or those from controls (173.00±13.21; p<0.01).Groups sharing a letter are not significantly different.

Mentions: No significant differences were observed in tibia ash weight between treatment groups (Table 2). Tibia lengths of birds treated with high, medium, and low levels of melatonin were all significantly longer than those from controls (F(3,74) = 5.43, p<0.01; Fig. 3). Tibia cortical thickness in birds treated with high levels of melatonin was significantly greater than in birds treated with low levels of melatonin (F(3,77) = 3.29, p<0.05; Fig. 4). Tibias from birds treated with high levels of melatonin had significantly greater break force compared to controls and birds treated with low levels of melatonin, but the tibia break force of birds treated with medium levels of melatonin did not differ from birds in other treatment groups (F(3,70) = 6.67, p<0.01; Fig. 5). Maximum force sustained was significantly greater in tibias from birds treated with high levels of melatonin compared to controls or from birds treated with medium levels of melatonin, but tibia maximum force in birds treated with medium levels of melatonin did not differ compared to those from birds treated with low or high levels of melatonin (F(3,76) = 6.91, p<0.001; Fig. 6). Maximum force of tibias from birds treated with low levels of melatonin did not differ from controls.


The effects of melatonin on the physical properties of bones and egg shells in the laying hen.

Taylor AC, Horvat-Gordon M, Moore A, Bartell PA - PLoS ONE (2013)

Tibia break force was significantly greater in birds treated with high concentrations of melatonin (244.03±14.19) compared to those from birds treated with low concentrations of melatonin 203.37±11.21) or those from controls (173.00±13.21; p<0.01).Groups sharing a letter are not significantly different.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585294&req=5

pone-0055663-g005: Tibia break force was significantly greater in birds treated with high concentrations of melatonin (244.03±14.19) compared to those from birds treated with low concentrations of melatonin 203.37±11.21) or those from controls (173.00±13.21; p<0.01).Groups sharing a letter are not significantly different.
Mentions: No significant differences were observed in tibia ash weight between treatment groups (Table 2). Tibia lengths of birds treated with high, medium, and low levels of melatonin were all significantly longer than those from controls (F(3,74) = 5.43, p<0.01; Fig. 3). Tibia cortical thickness in birds treated with high levels of melatonin was significantly greater than in birds treated with low levels of melatonin (F(3,77) = 3.29, p<0.05; Fig. 4). Tibias from birds treated with high levels of melatonin had significantly greater break force compared to controls and birds treated with low levels of melatonin, but the tibia break force of birds treated with medium levels of melatonin did not differ from birds in other treatment groups (F(3,70) = 6.67, p<0.01; Fig. 5). Maximum force sustained was significantly greater in tibias from birds treated with high levels of melatonin compared to controls or from birds treated with medium levels of melatonin, but tibia maximum force in birds treated with medium levels of melatonin did not differ compared to those from birds treated with low or high levels of melatonin (F(3,76) = 6.91, p<0.001; Fig. 6). Maximum force of tibias from birds treated with low levels of melatonin did not differ from controls.

Bottom Line: Hens treated with a high concentration of melatonin showed significant strengthening in their femur and tibia, as measured by maximum force sustained and breaking force, compared to controls.Egg weights from hens treated with melatonin were significantly greater than those from hens that were not treated with melatonin.Conversely, egg shell mass of hens treated with melatonin was significantly lower than those of hens not treated with melatonin.

View Article: PubMed Central - PubMed

Affiliation: Department of Animal Science, The Pennsylvania State University, University Park, Pennsylvania, USA.

ABSTRACT
Laying hens often experience unbalanced calcium utilization which can cause deficiencies in bone and egg mineralization. Because melatonin has been shown to affect bone mineralization in other animals, we examined whether treating hens with melatonin would affect eggshell thickness and improve skeletal performance, thereby reducing skeletal and egg shell defects. Birds were given a diet containing either low (30 µg/kg), medium (300 µg/kg), or high (3 mg/kg) concentrations of melatonin, or control feed through approximately one laying cycle. We examined the weight, length, and strength of egg, femur, tibia, and keel. Hens treated with a high concentration of melatonin showed significant strengthening in their femur and tibia, as measured by maximum force sustained and breaking force, compared to controls. Egg weights from hens treated with melatonin were significantly greater than those from hens that were not treated with melatonin. Conversely, egg shell mass of hens treated with melatonin was significantly lower than those of hens not treated with melatonin. Our data suggest that melatonin may affect the allocation of calcium to bone at the expense of egg shell mineralization.

Show MeSH
Related in: MedlinePlus