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Use of a modified spatial-context memory test to detect amnestic mild cognitive impairment.

Wang HM, Yang CM, Kuo WC, Huang CC, Kuo HC - PLoS ONE (2013)

Bottom Line: We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT.Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT.We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chang Gung Memorial Hospital and University Medical College, Linkou Medical Center, Taipei, Taiwan.

ABSTRACT
In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer's type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions affected in early m-DAT. We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT. Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT. Additionally, compared with other screening tests, our spatial context memory test showed high sensitivity and specificity in discerning those with a-MCI from the normal population but, was relatively ineffective in discriminating a-MCI patients from those with m-DAT. We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

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Receiver-operating characteristic curve showing the ability of each neuropsychological test to discriminate between normal controls and amnestic mild cognitive impairment patients.The event-place association and the total spatial context memory test score show higher discriminative power than the other tests used in this study. MMSE: Mini-mental status examination; VAMT: visual association memory test; TMT: trail making test; CERAD: Consortium to Establish Registry for Alzheimer’s disease; SCMT: Spatial Context Memory Test.
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pone-0057030-g005: Receiver-operating characteristic curve showing the ability of each neuropsychological test to discriminate between normal controls and amnestic mild cognitive impairment patients.The event-place association and the total spatial context memory test score show higher discriminative power than the other tests used in this study. MMSE: Mini-mental status examination; VAMT: visual association memory test; TMT: trail making test; CERAD: Consortium to Establish Registry for Alzheimer’s disease; SCMT: Spatial Context Memory Test.

Mentions: Figure 5 shows the receiver-operating curve (ROC) of the normal control and a-MCI groups for all neuropsychological tests. The AUC indicates that event-place association memory subtest was the most powerful of all tests in discriminating normal controls from the a-MCI group, reaching optimal results with cut point 5 (97% sensitivity, 100% specificity, 100% positive predictive values, and 96% negative predictive value). The SCMT total score also showed significant discrimination power, reaching the optimal results with cut point 15 (97% sensitivity, 93% specificity, 93% positive predictive values, and 96% negative predictive value; Table 5). Therefore, while the total SCMT score is comparatively better than the MMSE in detecting the a-MCI from normal controls it is not capable of distinguishing a-MCI from m-DAT (Table 3 and Table 5).


Use of a modified spatial-context memory test to detect amnestic mild cognitive impairment.

Wang HM, Yang CM, Kuo WC, Huang CC, Kuo HC - PLoS ONE (2013)

Receiver-operating characteristic curve showing the ability of each neuropsychological test to discriminate between normal controls and amnestic mild cognitive impairment patients.The event-place association and the total spatial context memory test score show higher discriminative power than the other tests used in this study. MMSE: Mini-mental status examination; VAMT: visual association memory test; TMT: trail making test; CERAD: Consortium to Establish Registry for Alzheimer’s disease; SCMT: Spatial Context Memory Test.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585255&req=5

pone-0057030-g005: Receiver-operating characteristic curve showing the ability of each neuropsychological test to discriminate between normal controls and amnestic mild cognitive impairment patients.The event-place association and the total spatial context memory test score show higher discriminative power than the other tests used in this study. MMSE: Mini-mental status examination; VAMT: visual association memory test; TMT: trail making test; CERAD: Consortium to Establish Registry for Alzheimer’s disease; SCMT: Spatial Context Memory Test.
Mentions: Figure 5 shows the receiver-operating curve (ROC) of the normal control and a-MCI groups for all neuropsychological tests. The AUC indicates that event-place association memory subtest was the most powerful of all tests in discriminating normal controls from the a-MCI group, reaching optimal results with cut point 5 (97% sensitivity, 100% specificity, 100% positive predictive values, and 96% negative predictive value). The SCMT total score also showed significant discrimination power, reaching the optimal results with cut point 15 (97% sensitivity, 93% specificity, 93% positive predictive values, and 96% negative predictive value; Table 5). Therefore, while the total SCMT score is comparatively better than the MMSE in detecting the a-MCI from normal controls it is not capable of distinguishing a-MCI from m-DAT (Table 3 and Table 5).

Bottom Line: We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT.Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT.We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chang Gung Memorial Hospital and University Medical College, Linkou Medical Center, Taipei, Taiwan.

ABSTRACT
In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer's type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions affected in early m-DAT. We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT. Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT. Additionally, compared with other screening tests, our spatial context memory test showed high sensitivity and specificity in discerning those with a-MCI from the normal population but, was relatively ineffective in discriminating a-MCI patients from those with m-DAT. We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

Show MeSH
Related in: MedlinePlus