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Use of a modified spatial-context memory test to detect amnestic mild cognitive impairment.

Wang HM, Yang CM, Kuo WC, Huang CC, Kuo HC - PLoS ONE (2013)

Bottom Line: We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT.Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT.We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chang Gung Memorial Hospital and University Medical College, Linkou Medical Center, Taipei, Taiwan.

ABSTRACT
In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer's type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions affected in early m-DAT. We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT. Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT. Additionally, compared with other screening tests, our spatial context memory test showed high sensitivity and specificity in discerning those with a-MCI from the normal population but, was relatively ineffective in discriminating a-MCI patients from those with m-DAT. We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

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Related in: MedlinePlus

Receiver operating characteristic test showing the ability of each neuropsychological test to discriminate between the amnestic mild cognitive impairment and mild dementia of Alzheimer’s type groups.The MMSE shows the highest discriminative power of the tests used in this study. MMSE: Mini-mental status examination; VAMT: visual association memory test; TMT: trail making test; CERAD: Consortium to Establish Registry for Alzheimer’s disease; SCMT: Spatial Context Memory Test.
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pone-0057030-g004: Receiver operating characteristic test showing the ability of each neuropsychological test to discriminate between the amnestic mild cognitive impairment and mild dementia of Alzheimer’s type groups.The MMSE shows the highest discriminative power of the tests used in this study. MMSE: Mini-mental status examination; VAMT: visual association memory test; TMT: trail making test; CERAD: Consortium to Establish Registry for Alzheimer’s disease; SCMT: Spatial Context Memory Test.

Mentions: The ROCs for the a-MCI and m-DAT groups on each neuropsychological test are shown in Figure 4. This analysis found that among all tests studied, the MMSE was best in differentially diagnosing participants with a-MCI from those with mild m-DAT (93% sensitivity and 96% specificity; Table 3).


Use of a modified spatial-context memory test to detect amnestic mild cognitive impairment.

Wang HM, Yang CM, Kuo WC, Huang CC, Kuo HC - PLoS ONE (2013)

Receiver operating characteristic test showing the ability of each neuropsychological test to discriminate between the amnestic mild cognitive impairment and mild dementia of Alzheimer’s type groups.The MMSE shows the highest discriminative power of the tests used in this study. MMSE: Mini-mental status examination; VAMT: visual association memory test; TMT: trail making test; CERAD: Consortium to Establish Registry for Alzheimer’s disease; SCMT: Spatial Context Memory Test.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585255&req=5

pone-0057030-g004: Receiver operating characteristic test showing the ability of each neuropsychological test to discriminate between the amnestic mild cognitive impairment and mild dementia of Alzheimer’s type groups.The MMSE shows the highest discriminative power of the tests used in this study. MMSE: Mini-mental status examination; VAMT: visual association memory test; TMT: trail making test; CERAD: Consortium to Establish Registry for Alzheimer’s disease; SCMT: Spatial Context Memory Test.
Mentions: The ROCs for the a-MCI and m-DAT groups on each neuropsychological test are shown in Figure 4. This analysis found that among all tests studied, the MMSE was best in differentially diagnosing participants with a-MCI from those with mild m-DAT (93% sensitivity and 96% specificity; Table 3).

Bottom Line: We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT.Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT.We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chang Gung Memorial Hospital and University Medical College, Linkou Medical Center, Taipei, Taiwan.

ABSTRACT
In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer's type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions affected in early m-DAT. We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT. Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT. Additionally, compared with other screening tests, our spatial context memory test showed high sensitivity and specificity in discerning those with a-MCI from the normal population but, was relatively ineffective in discriminating a-MCI patients from those with m-DAT. We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

Show MeSH
Related in: MedlinePlus