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Use of a modified spatial-context memory test to detect amnestic mild cognitive impairment.

Wang HM, Yang CM, Kuo WC, Huang CC, Kuo HC - PLoS ONE (2013)

Bottom Line: We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT.Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT.We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chang Gung Memorial Hospital and University Medical College, Linkou Medical Center, Taipei, Taiwan.

ABSTRACT
In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer's type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions affected in early m-DAT. We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT. Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT. Additionally, compared with other screening tests, our spatial context memory test showed high sensitivity and specificity in discerning those with a-MCI from the normal population but, was relatively ineffective in discriminating a-MCI patients from those with m-DAT. We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

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Related in: MedlinePlus

Flow chart illustrating the place-object.
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pone-0057030-g003: Flow chart illustrating the place-object.

Mentions: A flow chart describing the place-object association memory subset is shown in Figure 3. Briefly, two different backgrounds (a 3D representation of a living room or kitchen) would randomly appear, then a red dot would flash for 3 seconds in the center of the screen, and then the screen would be switched to show the background for one second. This was quickly followed by a presentation of the background in combination with a daily life good or similar object for 4 seconds, followed by a blank screen for one second before continuing to another set. There were a total of 10 sets of combined stimuli with each background eventually being paired with 5 different objects. During the inquiry period, one of the backgrounds would be presented followed by 2 objects located below it. The patient was then asked to identify which one was paired with the presented background. This was repeated for a total of 10 questions with each correct answer given 1 point. The total score was the sum of all three subtests and ranged from 0 to 26.


Use of a modified spatial-context memory test to detect amnestic mild cognitive impairment.

Wang HM, Yang CM, Kuo WC, Huang CC, Kuo HC - PLoS ONE (2013)

Flow chart illustrating the place-object.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585255&req=5

pone-0057030-g003: Flow chart illustrating the place-object.
Mentions: A flow chart describing the place-object association memory subset is shown in Figure 3. Briefly, two different backgrounds (a 3D representation of a living room or kitchen) would randomly appear, then a red dot would flash for 3 seconds in the center of the screen, and then the screen would be switched to show the background for one second. This was quickly followed by a presentation of the background in combination with a daily life good or similar object for 4 seconds, followed by a blank screen for one second before continuing to another set. There were a total of 10 sets of combined stimuli with each background eventually being paired with 5 different objects. During the inquiry period, one of the backgrounds would be presented followed by 2 objects located below it. The patient was then asked to identify which one was paired with the presented background. This was repeated for a total of 10 questions with each correct answer given 1 point. The total score was the sum of all three subtests and ranged from 0 to 26.

Bottom Line: We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT.Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT.We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chang Gung Memorial Hospital and University Medical College, Linkou Medical Center, Taipei, Taiwan.

ABSTRACT
In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer's type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions affected in early m-DAT. We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT. Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT. Additionally, compared with other screening tests, our spatial context memory test showed high sensitivity and specificity in discerning those with a-MCI from the normal population but, was relatively ineffective in discriminating a-MCI patients from those with m-DAT. We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

Show MeSH
Related in: MedlinePlus