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Use of a modified spatial-context memory test to detect amnestic mild cognitive impairment.

Wang HM, Yang CM, Kuo WC, Huang CC, Kuo HC - PLoS ONE (2013)

Bottom Line: We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT.Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT.We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chang Gung Memorial Hospital and University Medical College, Linkou Medical Center, Taipei, Taiwan.

ABSTRACT
In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer's type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions affected in early m-DAT. We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT. Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT. Additionally, compared with other screening tests, our spatial context memory test showed high sensitivity and specificity in discerning those with a-MCI from the normal population but, was relatively ineffective in discriminating a-MCI patients from those with m-DAT. We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

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Related in: MedlinePlus

Flow chart illustrating the event-place memory test.
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pone-0057030-g002: Flow chart illustrating the event-place memory test.

Mentions: A flow chart describing the event-place association memory subset is shown in Figure 2. Briefly, as in the previous test, a city map would be first presented, and a flashing red dot appeared on a specific block in the map so as to minimize any bias between tests resulting from attention differences. This red dot flashed for 3 seconds and then the screen was switched to show a black-and white photo of a scene for one second, after which an event would tightly follow. Then the scene and the event would appear together for 4 seconds, followed by a blank screen for one second before continuing to another set. This was repeated for a total of 10 sets of scene and event associations, after which there would be 5 seconds of blank screen followed by the inquiry. During the inquiry period, the events were shown and the subject was asked which one of the two scenes below it was associated with. There were a total of 10 questions with 1 point given for each correct answer.


Use of a modified spatial-context memory test to detect amnestic mild cognitive impairment.

Wang HM, Yang CM, Kuo WC, Huang CC, Kuo HC - PLoS ONE (2013)

Flow chart illustrating the event-place memory test.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585255&req=5

pone-0057030-g002: Flow chart illustrating the event-place memory test.
Mentions: A flow chart describing the event-place association memory subset is shown in Figure 2. Briefly, as in the previous test, a city map would be first presented, and a flashing red dot appeared on a specific block in the map so as to minimize any bias between tests resulting from attention differences. This red dot flashed for 3 seconds and then the screen was switched to show a black-and white photo of a scene for one second, after which an event would tightly follow. Then the scene and the event would appear together for 4 seconds, followed by a blank screen for one second before continuing to another set. This was repeated for a total of 10 sets of scene and event associations, after which there would be 5 seconds of blank screen followed by the inquiry. During the inquiry period, the events were shown and the subject was asked which one of the two scenes below it was associated with. There were a total of 10 questions with 1 point given for each correct answer.

Bottom Line: We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT.Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT.We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chang Gung Memorial Hospital and University Medical College, Linkou Medical Center, Taipei, Taiwan.

ABSTRACT
In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer's type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions affected in early m-DAT. We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT. Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT. Additionally, compared with other screening tests, our spatial context memory test showed high sensitivity and specificity in discerning those with a-MCI from the normal population but, was relatively ineffective in discriminating a-MCI patients from those with m-DAT. We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

Show MeSH
Related in: MedlinePlus