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Use of a modified spatial-context memory test to detect amnestic mild cognitive impairment.

Wang HM, Yang CM, Kuo WC, Huang CC, Kuo HC - PLoS ONE (2013)

Bottom Line: We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT.Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT.We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chang Gung Memorial Hospital and University Medical College, Linkou Medical Center, Taipei, Taiwan.

ABSTRACT
In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer's type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions affected in early m-DAT. We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT. Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT. Additionally, compared with other screening tests, our spatial context memory test showed high sensitivity and specificity in discerning those with a-MCI from the normal population but, was relatively ineffective in discriminating a-MCI patients from those with m-DAT. We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

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Related in: MedlinePlus

Flow chart illustrating the spatial context memory test.
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pone-0057030-g001: Flow chart illustrating the spatial context memory test.

Mentions: A flow chart illustrating the spatial location memory test is shown in Figure 1. Briefly, during the appearance the stimulus, a city map would be presented with blocks of buildings (identified by name) arranged around the map. A flashing red dot would appear on a particular block in the map and after the red dot flashed for 5 seconds, the screen would be switched to show photos of this building. This was followed by one second of blank screen, and then another randomly chosen block was used for a total of 6 different locations. After all 6 different stimulations were shown, there were 5 seconds of blank screen, and then the inquiry period would begin. This involved presenting photos of a specific building with the subject asked to identify its location on the map. One point was given for every correct answer with a highest possible score of 6.


Use of a modified spatial-context memory test to detect amnestic mild cognitive impairment.

Wang HM, Yang CM, Kuo WC, Huang CC, Kuo HC - PLoS ONE (2013)

Flow chart illustrating the spatial context memory test.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585255&req=5

pone-0057030-g001: Flow chart illustrating the spatial context memory test.
Mentions: A flow chart illustrating the spatial location memory test is shown in Figure 1. Briefly, during the appearance the stimulus, a city map would be presented with blocks of buildings (identified by name) arranged around the map. A flashing red dot would appear on a particular block in the map and after the red dot flashed for 5 seconds, the screen would be switched to show photos of this building. This was followed by one second of blank screen, and then another randomly chosen block was used for a total of 6 different locations. After all 6 different stimulations were shown, there were 5 seconds of blank screen, and then the inquiry period would begin. This involved presenting photos of a specific building with the subject asked to identify its location on the map. One point was given for every correct answer with a highest possible score of 6.

Bottom Line: We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT.Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT.We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chang Gung Memorial Hospital and University Medical College, Linkou Medical Center, Taipei, Taiwan.

ABSTRACT
In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer's type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions affected in early m-DAT. We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT. Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT. Additionally, compared with other screening tests, our spatial context memory test showed high sensitivity and specificity in discerning those with a-MCI from the normal population but, was relatively ineffective in discriminating a-MCI patients from those with m-DAT. We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.

Show MeSH
Related in: MedlinePlus