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A novel statistical prognostic score model that includes serum CXCL5 levels and clinical classification predicts risk of disease progression and survival of nasopharyngeal carcinoma patients.

Zhang H, Xia W, Lu X, Sun R, Wang L, Zheng L, Ye Y, Bao Y, Xiang Y, Guo X - PLoS ONE (2013)

Bottom Line: Sex, age, histology, T classification, clinical classification and local recurrence were not associated with sCXCL5 levels.Furthermore, this novel model successfully divided the patients into four risk subgroups in the training set, the testing set and the entire set of patients.The novel statistical C-C model, which includes sCXCL5 levels and clinical classification, could be helpful in predicting the prognosis of NPC patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou, China.

ABSTRACT

Background: Aberrant expression of C-X-C motif chemokine 5 (CXCL5) contributes to the progression of various cancers. This study analyzed the clinical significance of serum CXCL5 (sCXCL5) levels of nasopharyngeal carcinoma (NPC) patients, with the goal of building a novel prognostic score model.

Experimental design: Serum samples were collected prior to treatment from 290 NPC patients for the detection of sCXCL5 with ELISA. Half of the patients (n = 145) were randomly assigned to the training set to generate the sCXCL5 cutoff point using receiver operator characteristic (ROC) analysis, while the other half (n = 145) were assigned to the testing set for validation. Associations between sCXCL5 levels and clinical characteristics were analyzed. A prognostic score model was built using independent predictors derived from multivariate analysis. A concordance index (C-Index) was used to evaluate prognostic ability.

Results: The sCXCL5 cutoff point was 0.805 ng/ml. Sex, age, histology, T classification, clinical classification and local recurrence were not associated with sCXCL5 levels. However, sCXCL5 levels were positively associated with N classification, distant metastasis and disease progression (P<0.05). A high sCXCL5 level predicted poor 6-year overall survival (OS), poor 6-year distant metastasis-free survival (DMFS), and poor 6-year progression-free survival (PFS). A prognostic score model was subsequently constructed based on sCXCL5 levels and clinical classification (C-C model), which are independent predictors of OS, DMFS, and PFS, as confirmed by the multivariate analysis. Furthermore, this novel model successfully divided the patients into four risk subgroups in the training set, the testing set and the entire set of patients. The C-Indices were 0.751 and 0.762 for the training set and the testing set, respectively.

Conclusions: sCXCL5 level was determined to be an independent prognostic factor for NPC patients. The novel statistical C-C model, which includes sCXCL5 levels and clinical classification, could be helpful in predicting the prognosis of NPC patients.

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Related in: MedlinePlus

The survival curves for the nasopharyngeal carcinoma patients with high/low serum CXCL5-levels in the training set.A high sCXCL5 level correlated with poor overall survival and distant metastasis-free survival rates in the training set patients. (A) The overall survival rate was significantly higher in the low sCXCL5 level patients; (B) The distant metastasis-free survival rate was significantly higher in the low sCXCL5 level patients. Low sCXCL5 level, n = 70; high sCXCL5 level, n = 75.
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pone-0057830-g001: The survival curves for the nasopharyngeal carcinoma patients with high/low serum CXCL5-levels in the training set.A high sCXCL5 level correlated with poor overall survival and distant metastasis-free survival rates in the training set patients. (A) The overall survival rate was significantly higher in the low sCXCL5 level patients; (B) The distant metastasis-free survival rate was significantly higher in the low sCXCL5 level patients. Low sCXCL5 level, n = 70; high sCXCL5 level, n = 75.

Mentions: In the training set, the 6-year-OS rates for the low sCXCL5 level group and the high sCXCL5 level group were 75% and 54%, respectively (P = 0.034). The 6-year-DMFS rates for the low sCXCL5 level group and the high sCXCL5 level group were 82% and 63% (P = 0.014), respectively (Figure 1 shows the complete follow-up). The 6-year-PFS rates for the low sCXCL5 level group and the high sCXCL5 level group were 65% and 45% (P = 0.021), respectively. However, there were no significant differences in the 6-year-LRRFS rates of the two groups, with 75% and 77% (P = 0.955) LRRFS rates for the high and low sCXCL5 level groups, respectively.


A novel statistical prognostic score model that includes serum CXCL5 levels and clinical classification predicts risk of disease progression and survival of nasopharyngeal carcinoma patients.

Zhang H, Xia W, Lu X, Sun R, Wang L, Zheng L, Ye Y, Bao Y, Xiang Y, Guo X - PLoS ONE (2013)

The survival curves for the nasopharyngeal carcinoma patients with high/low serum CXCL5-levels in the training set.A high sCXCL5 level correlated with poor overall survival and distant metastasis-free survival rates in the training set patients. (A) The overall survival rate was significantly higher in the low sCXCL5 level patients; (B) The distant metastasis-free survival rate was significantly higher in the low sCXCL5 level patients. Low sCXCL5 level, n = 70; high sCXCL5 level, n = 75.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585222&req=5

pone-0057830-g001: The survival curves for the nasopharyngeal carcinoma patients with high/low serum CXCL5-levels in the training set.A high sCXCL5 level correlated with poor overall survival and distant metastasis-free survival rates in the training set patients. (A) The overall survival rate was significantly higher in the low sCXCL5 level patients; (B) The distant metastasis-free survival rate was significantly higher in the low sCXCL5 level patients. Low sCXCL5 level, n = 70; high sCXCL5 level, n = 75.
Mentions: In the training set, the 6-year-OS rates for the low sCXCL5 level group and the high sCXCL5 level group were 75% and 54%, respectively (P = 0.034). The 6-year-DMFS rates for the low sCXCL5 level group and the high sCXCL5 level group were 82% and 63% (P = 0.014), respectively (Figure 1 shows the complete follow-up). The 6-year-PFS rates for the low sCXCL5 level group and the high sCXCL5 level group were 65% and 45% (P = 0.021), respectively. However, there were no significant differences in the 6-year-LRRFS rates of the two groups, with 75% and 77% (P = 0.955) LRRFS rates for the high and low sCXCL5 level groups, respectively.

Bottom Line: Sex, age, histology, T classification, clinical classification and local recurrence were not associated with sCXCL5 levels.Furthermore, this novel model successfully divided the patients into four risk subgroups in the training set, the testing set and the entire set of patients.The novel statistical C-C model, which includes sCXCL5 levels and clinical classification, could be helpful in predicting the prognosis of NPC patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou, China.

ABSTRACT

Background: Aberrant expression of C-X-C motif chemokine 5 (CXCL5) contributes to the progression of various cancers. This study analyzed the clinical significance of serum CXCL5 (sCXCL5) levels of nasopharyngeal carcinoma (NPC) patients, with the goal of building a novel prognostic score model.

Experimental design: Serum samples were collected prior to treatment from 290 NPC patients for the detection of sCXCL5 with ELISA. Half of the patients (n = 145) were randomly assigned to the training set to generate the sCXCL5 cutoff point using receiver operator characteristic (ROC) analysis, while the other half (n = 145) were assigned to the testing set for validation. Associations between sCXCL5 levels and clinical characteristics were analyzed. A prognostic score model was built using independent predictors derived from multivariate analysis. A concordance index (C-Index) was used to evaluate prognostic ability.

Results: The sCXCL5 cutoff point was 0.805 ng/ml. Sex, age, histology, T classification, clinical classification and local recurrence were not associated with sCXCL5 levels. However, sCXCL5 levels were positively associated with N classification, distant metastasis and disease progression (P<0.05). A high sCXCL5 level predicted poor 6-year overall survival (OS), poor 6-year distant metastasis-free survival (DMFS), and poor 6-year progression-free survival (PFS). A prognostic score model was subsequently constructed based on sCXCL5 levels and clinical classification (C-C model), which are independent predictors of OS, DMFS, and PFS, as confirmed by the multivariate analysis. Furthermore, this novel model successfully divided the patients into four risk subgroups in the training set, the testing set and the entire set of patients. The C-Indices were 0.751 and 0.762 for the training set and the testing set, respectively.

Conclusions: sCXCL5 level was determined to be an independent prognostic factor for NPC patients. The novel statistical C-C model, which includes sCXCL5 levels and clinical classification, could be helpful in predicting the prognosis of NPC patients.

Show MeSH
Related in: MedlinePlus