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Assessment of olfactory nerve by SPECT-MRI image with nasal thallium-201 administration in patients with olfactory impairments in comparison to healthy volunteers.

Shiga H, Taki J, Washiyama K, Yamamoto J, Kinase S, Okuda K, Kinuya S, Watanabe N, Tonami H, Koshida K, Amano R, Furukawa M, Miwa T - PLoS ONE (2013)

Bottom Line: Separate MRI images were merged with the SPECT images. (201)Tl olfactory migration was also correlated with the volume of the olfactory bulb determined from MRI images, as well as with odor recognition thresholds measured by using T&T olfactometry.The migration of (201)Tl to the olfactory bulb was significantly correlated with odor recognition thresholds obtained with T&T olfactometry and correlated with the volume of the olfactory bulb determined from MRI images when all subjects were included.Assessment of the (201)Tl migration to the olfactory bulb was the new method for the evaluation of the olfactory nerve connectivity in patients with impaired olfaction.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology, Kanazawa Medical University, Ishikawa, Japan. shigah@kanazawa-med.ac.jp

ABSTRACT

Purpose: The aim of this study was to assess whether migration of thallium-201 ((201)Tl) to the olfactory bulb were reduced in patients with olfactory impairments in comparison to healthy volunteers after nasal administration of (201)Tl.

Procedures: 10 healthy volunteers and 21 patients enrolled in the study (19 males and 12 females; 26-71 years old). The causes of olfactory dysfunction in the patients were head trauma (n = 7), upper respiratory tract infection (n = 7), and chronic rhinosinusitis (n = 7). (201)TlCl was administered unilaterally to the olfactory cleft, and SPECT-CT was conducted 24 h later. Separate MRI images were merged with the SPECT images. (201)Tl olfactory migration was also correlated with the volume of the olfactory bulb determined from MRI images, as well as with odor recognition thresholds measured by using T&T olfactometry.

Results: Nasal (201)Tl migration to the olfactory bulb was significantly lower in the olfactory-impaired patients than in healthy volunteers. The migration of (201)Tl to the olfactory bulb was significantly correlated with odor recognition thresholds obtained with T&T olfactometry and correlated with the volume of the olfactory bulb determined from MRI images when all subjects were included.

Conclusions: Assessment of the (201)Tl migration to the olfactory bulb was the new method for the evaluation of the olfactory nerve connectivity in patients with impaired olfaction.

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Related in: MedlinePlus

Correlation between olfactory 201Tl migration and olfactory function as assessed by T&T olfactometry.Nasal 201Tl migration to the olfactory bulb as a function of odor recognition threshold in patients and healthy volunteers (n = 31). Spearman r = –0.62, P = 0.0002. Closed circles, patients; Open squares, healthy volunteers.
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pone-0057671-g004: Correlation between olfactory 201Tl migration and olfactory function as assessed by T&T olfactometry.Nasal 201Tl migration to the olfactory bulb as a function of odor recognition threshold in patients and healthy volunteers (n = 31). Spearman r = –0.62, P = 0.0002. Closed circles, patients; Open squares, healthy volunteers.

Mentions: Nasal 201Tl migration to the olfactory bulb was correlated with the odor recognition threshold obtained by T&T olfactometry (Spearman r = –0.62, P = 0.0002) in the healthy volunteers and the olfaction-impaired patients evaluated as a single group (Fig. 4). Nasal 201Tl migration to the olfactory bulb was not correlated with duration of olfactory deficits at the time of the examination in the patients with impaired olfaction (Spearman r = 0.33, P = 0.15).


Assessment of olfactory nerve by SPECT-MRI image with nasal thallium-201 administration in patients with olfactory impairments in comparison to healthy volunteers.

Shiga H, Taki J, Washiyama K, Yamamoto J, Kinase S, Okuda K, Kinuya S, Watanabe N, Tonami H, Koshida K, Amano R, Furukawa M, Miwa T - PLoS ONE (2013)

Correlation between olfactory 201Tl migration and olfactory function as assessed by T&T olfactometry.Nasal 201Tl migration to the olfactory bulb as a function of odor recognition threshold in patients and healthy volunteers (n = 31). Spearman r = –0.62, P = 0.0002. Closed circles, patients; Open squares, healthy volunteers.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585209&req=5

pone-0057671-g004: Correlation between olfactory 201Tl migration and olfactory function as assessed by T&T olfactometry.Nasal 201Tl migration to the olfactory bulb as a function of odor recognition threshold in patients and healthy volunteers (n = 31). Spearman r = –0.62, P = 0.0002. Closed circles, patients; Open squares, healthy volunteers.
Mentions: Nasal 201Tl migration to the olfactory bulb was correlated with the odor recognition threshold obtained by T&T olfactometry (Spearman r = –0.62, P = 0.0002) in the healthy volunteers and the olfaction-impaired patients evaluated as a single group (Fig. 4). Nasal 201Tl migration to the olfactory bulb was not correlated with duration of olfactory deficits at the time of the examination in the patients with impaired olfaction (Spearman r = 0.33, P = 0.15).

Bottom Line: Separate MRI images were merged with the SPECT images. (201)Tl olfactory migration was also correlated with the volume of the olfactory bulb determined from MRI images, as well as with odor recognition thresholds measured by using T&T olfactometry.The migration of (201)Tl to the olfactory bulb was significantly correlated with odor recognition thresholds obtained with T&T olfactometry and correlated with the volume of the olfactory bulb determined from MRI images when all subjects were included.Assessment of the (201)Tl migration to the olfactory bulb was the new method for the evaluation of the olfactory nerve connectivity in patients with impaired olfaction.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology, Kanazawa Medical University, Ishikawa, Japan. shigah@kanazawa-med.ac.jp

ABSTRACT

Purpose: The aim of this study was to assess whether migration of thallium-201 ((201)Tl) to the olfactory bulb were reduced in patients with olfactory impairments in comparison to healthy volunteers after nasal administration of (201)Tl.

Procedures: 10 healthy volunteers and 21 patients enrolled in the study (19 males and 12 females; 26-71 years old). The causes of olfactory dysfunction in the patients were head trauma (n = 7), upper respiratory tract infection (n = 7), and chronic rhinosinusitis (n = 7). (201)TlCl was administered unilaterally to the olfactory cleft, and SPECT-CT was conducted 24 h later. Separate MRI images were merged with the SPECT images. (201)Tl olfactory migration was also correlated with the volume of the olfactory bulb determined from MRI images, as well as with odor recognition thresholds measured by using T&T olfactometry.

Results: Nasal (201)Tl migration to the olfactory bulb was significantly lower in the olfactory-impaired patients than in healthy volunteers. The migration of (201)Tl to the olfactory bulb was significantly correlated with odor recognition thresholds obtained with T&T olfactometry and correlated with the volume of the olfactory bulb determined from MRI images when all subjects were included.

Conclusions: Assessment of the (201)Tl migration to the olfactory bulb was the new method for the evaluation of the olfactory nerve connectivity in patients with impaired olfaction.

Show MeSH
Related in: MedlinePlus