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Assessment of olfactory nerve by SPECT-MRI image with nasal thallium-201 administration in patients with olfactory impairments in comparison to healthy volunteers.

Shiga H, Taki J, Washiyama K, Yamamoto J, Kinase S, Okuda K, Kinuya S, Watanabe N, Tonami H, Koshida K, Amano R, Furukawa M, Miwa T - PLoS ONE (2013)

Bottom Line: Separate MRI images were merged with the SPECT images. (201)Tl olfactory migration was also correlated with the volume of the olfactory bulb determined from MRI images, as well as with odor recognition thresholds measured by using T&T olfactometry.The migration of (201)Tl to the olfactory bulb was significantly correlated with odor recognition thresholds obtained with T&T olfactometry and correlated with the volume of the olfactory bulb determined from MRI images when all subjects were included.Assessment of the (201)Tl migration to the olfactory bulb was the new method for the evaluation of the olfactory nerve connectivity in patients with impaired olfaction.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology, Kanazawa Medical University, Ishikawa, Japan. shigah@kanazawa-med.ac.jp

ABSTRACT

Purpose: The aim of this study was to assess whether migration of thallium-201 ((201)Tl) to the olfactory bulb were reduced in patients with olfactory impairments in comparison to healthy volunteers after nasal administration of (201)Tl.

Procedures: 10 healthy volunteers and 21 patients enrolled in the study (19 males and 12 females; 26-71 years old). The causes of olfactory dysfunction in the patients were head trauma (n = 7), upper respiratory tract infection (n = 7), and chronic rhinosinusitis (n = 7). (201)TlCl was administered unilaterally to the olfactory cleft, and SPECT-CT was conducted 24 h later. Separate MRI images were merged with the SPECT images. (201)Tl olfactory migration was also correlated with the volume of the olfactory bulb determined from MRI images, as well as with odor recognition thresholds measured by using T&T olfactometry.

Results: Nasal (201)Tl migration to the olfactory bulb was significantly lower in the olfactory-impaired patients than in healthy volunteers. The migration of (201)Tl to the olfactory bulb was significantly correlated with odor recognition thresholds obtained with T&T olfactometry and correlated with the volume of the olfactory bulb determined from MRI images when all subjects were included.

Conclusions: Assessment of the (201)Tl migration to the olfactory bulb was the new method for the evaluation of the olfactory nerve connectivity in patients with impaired olfaction.

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Related in: MedlinePlus

201Tl migration in patients with impaired olfaction in comparison to healthy volunteers.Nasal 201Tl migration to the olfactory bulb in healthy volunteers (n = 10) and patients with impaired olfaction due to head trauma (n = 7), upper respiratory tract infection (respiratory infection; n = 7), or chronic rhinosinusitis (n = 7). P values were obtained with Bonferroni’s multiple comparison test and the Kruskal-Wallis test. Bars: Mean ± S.D.
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pone-0057671-g001: 201Tl migration in patients with impaired olfaction in comparison to healthy volunteers.Nasal 201Tl migration to the olfactory bulb in healthy volunteers (n = 10) and patients with impaired olfaction due to head trauma (n = 7), upper respiratory tract infection (respiratory infection; n = 7), or chronic rhinosinusitis (n = 7). P values were obtained with Bonferroni’s multiple comparison test and the Kruskal-Wallis test. Bars: Mean ± S.D.

Mentions: To determine whether the viability or function of the peripheral olfactory nerve was reduced in the patients with impaired olfaction, we assessed migration of nasally administered 201Tl to the olfactory bulb in the patients and healthy volunteers. Migration of nasal 201Tl to the olfactory bulb was significantly lower in the patients with head trauma, upper respiratory infection, or chronic sinusitis than in the healthy volunteers (Fig. 1; Kruskal-Wallis test for comparing 4 groups, P = 0.0004; unpaired t-tests for comparing 2 groups: head trauma, P = 0.0005; upper respiratory tract infection, P = 0.0001; chronic sinusitis, P = 0.0003; Bonferroni’s multiple comparison test for comparing 2 groups: head trauma, P<0.0001; upper respiratory tract infection, P<0.0001; chronic sinusitis, P<0.0001). There were no significant differences between each patient group in migration of nasally administered 201Tl to the olfactory bulb.


Assessment of olfactory nerve by SPECT-MRI image with nasal thallium-201 administration in patients with olfactory impairments in comparison to healthy volunteers.

Shiga H, Taki J, Washiyama K, Yamamoto J, Kinase S, Okuda K, Kinuya S, Watanabe N, Tonami H, Koshida K, Amano R, Furukawa M, Miwa T - PLoS ONE (2013)

201Tl migration in patients with impaired olfaction in comparison to healthy volunteers.Nasal 201Tl migration to the olfactory bulb in healthy volunteers (n = 10) and patients with impaired olfaction due to head trauma (n = 7), upper respiratory tract infection (respiratory infection; n = 7), or chronic rhinosinusitis (n = 7). P values were obtained with Bonferroni’s multiple comparison test and the Kruskal-Wallis test. Bars: Mean ± S.D.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585209&req=5

pone-0057671-g001: 201Tl migration in patients with impaired olfaction in comparison to healthy volunteers.Nasal 201Tl migration to the olfactory bulb in healthy volunteers (n = 10) and patients with impaired olfaction due to head trauma (n = 7), upper respiratory tract infection (respiratory infection; n = 7), or chronic rhinosinusitis (n = 7). P values were obtained with Bonferroni’s multiple comparison test and the Kruskal-Wallis test. Bars: Mean ± S.D.
Mentions: To determine whether the viability or function of the peripheral olfactory nerve was reduced in the patients with impaired olfaction, we assessed migration of nasally administered 201Tl to the olfactory bulb in the patients and healthy volunteers. Migration of nasal 201Tl to the olfactory bulb was significantly lower in the patients with head trauma, upper respiratory infection, or chronic sinusitis than in the healthy volunteers (Fig. 1; Kruskal-Wallis test for comparing 4 groups, P = 0.0004; unpaired t-tests for comparing 2 groups: head trauma, P = 0.0005; upper respiratory tract infection, P = 0.0001; chronic sinusitis, P = 0.0003; Bonferroni’s multiple comparison test for comparing 2 groups: head trauma, P<0.0001; upper respiratory tract infection, P<0.0001; chronic sinusitis, P<0.0001). There were no significant differences between each patient group in migration of nasally administered 201Tl to the olfactory bulb.

Bottom Line: Separate MRI images were merged with the SPECT images. (201)Tl olfactory migration was also correlated with the volume of the olfactory bulb determined from MRI images, as well as with odor recognition thresholds measured by using T&T olfactometry.The migration of (201)Tl to the olfactory bulb was significantly correlated with odor recognition thresholds obtained with T&T olfactometry and correlated with the volume of the olfactory bulb determined from MRI images when all subjects were included.Assessment of the (201)Tl migration to the olfactory bulb was the new method for the evaluation of the olfactory nerve connectivity in patients with impaired olfaction.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology, Kanazawa Medical University, Ishikawa, Japan. shigah@kanazawa-med.ac.jp

ABSTRACT

Purpose: The aim of this study was to assess whether migration of thallium-201 ((201)Tl) to the olfactory bulb were reduced in patients with olfactory impairments in comparison to healthy volunteers after nasal administration of (201)Tl.

Procedures: 10 healthy volunteers and 21 patients enrolled in the study (19 males and 12 females; 26-71 years old). The causes of olfactory dysfunction in the patients were head trauma (n = 7), upper respiratory tract infection (n = 7), and chronic rhinosinusitis (n = 7). (201)TlCl was administered unilaterally to the olfactory cleft, and SPECT-CT was conducted 24 h later. Separate MRI images were merged with the SPECT images. (201)Tl olfactory migration was also correlated with the volume of the olfactory bulb determined from MRI images, as well as with odor recognition thresholds measured by using T&T olfactometry.

Results: Nasal (201)Tl migration to the olfactory bulb was significantly lower in the olfactory-impaired patients than in healthy volunteers. The migration of (201)Tl to the olfactory bulb was significantly correlated with odor recognition thresholds obtained with T&T olfactometry and correlated with the volume of the olfactory bulb determined from MRI images when all subjects were included.

Conclusions: Assessment of the (201)Tl migration to the olfactory bulb was the new method for the evaluation of the olfactory nerve connectivity in patients with impaired olfaction.

Show MeSH
Related in: MedlinePlus