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Impact of chronodisruption during primate pregnancy on the maternal and newborn temperature rhythms.

Serón-Ferré M, Forcelledo ML, Torres-Farfan C, Valenzuela FJ, Rojas A, Vergara M, Rojas-Garcia PP, Recabarren MP, Valenzuela GJ - PLoS ONE (2013)

Bottom Line: In addition, mean temperature was decreased (34.0±0.6 vs 36.1±0.2°C, in LL and control, respectively P<0.05).Our findings demonstrate that prenatal melatonin is a Zeitgeber for the newborn temperature rhythm and supports normal body temperature maintenance.Altogether these prenatal melatonin effects highlight the physiological importance of the maternal melatonin rhythm during pregnancy for the newborn primate.

View Article: PubMed Central - PubMed

Affiliation: Programa de Fisiopatología, Facultad de Medicina, Universidad de Chile, Santiago, Chile. mseron@med.uchile.cl

ABSTRACT
Disruption of the maternal environment during pregnancy is a key contributor to offspring diseases that develop in adult life. To explore the impact of chronodisruption during pregnancy in primates, we exposed pregnant capuchin monkeys to constant light (eliminating the maternal melatonin rhythm) from the last third of gestation to term. Maternal temperature and activity circadian rhythms were assessed as well as the newborn temperature rhythm. Additionally we studied the effect of daily maternal melatonin replacement during pregnancy on these rhythms. Ten pregnant capuchin monkeys were exposed to constant light from 60% of gestation to term. Five received a daily oral dose of melatonin (250 µg kg/body weight) at 1800 h (LL+Mel) and the other five a placebo (LL). Six additional pregnant females were maintained in a 14∶10 light:dark cycles and their newborns were used as controls (LD). Rhythms were recorded 96 h before delivery in the mother and at 4-6 days of age in the newborn. Exposure to constant light had no effect on the maternal body temperature rhythm however it delayed the acrophase of the activity rhythm. Neither rhythm was affected by melatonin replacement. In contrast, maternal exposure to constant light affected the newborn body temperature rhythm. This rhythm was entrained in control newborns whereas LL newborns showed a random distribution of the acrophases over 24-h. In addition, mean temperature was decreased (34.0±0.6 vs 36.1±0.2°C, in LL and control, respectively P<0.05). Maternal melatonin replacement during pregnancy re-synchronized the acrophases and restored mean temperature to the values in control newborns. Our findings demonstrate that prenatal melatonin is a Zeitgeber for the newborn temperature rhythm and supports normal body temperature maintenance. Altogether these prenatal melatonin effects highlight the physiological importance of the maternal melatonin rhythm during pregnancy for the newborn primate.

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Representative examples of circadian rhythms of activity (left panel) and temperature (right panel) in three pregnant capuchin monkeys.LD: females maintained in light:dark 14∶10 during pregnancy; LL: females maintained in constant light during pregnancy; LL+M: LL females receiving a daily melatonin replacement at 1800 h. The arrows indicates delivery.
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pone-0057710-g001: Representative examples of circadian rhythms of activity (left panel) and temperature (right panel) in three pregnant capuchin monkeys.LD: females maintained in light:dark 14∶10 during pregnancy; LL: females maintained in constant light during pregnancy; LL+M: LL females receiving a daily melatonin replacement at 1800 h. The arrows indicates delivery.

Mentions: Activity and temperature rhythms were detected in all pregnant females, before and after delivery (Figure 1). Regardless of the treatment, the day preceding delivery, and one day postpartum, some females showed decreased activity and tended to spend most of the day in a corner of the cage, usually away from the telemetry receiver, resulting in missing data points in the record. Activity resumed to values observed before delivery in the following postpartum days. Temperature increased during the first 48 h following delivery in most females although comparison of mesor before and after delivery did not reach significance. Activity and temperature rhythms were calculated from the 24-h recordings of each rhythm obtained 96 hours before delivery in order to compare animals in the same condition.


Impact of chronodisruption during primate pregnancy on the maternal and newborn temperature rhythms.

Serón-Ferré M, Forcelledo ML, Torres-Farfan C, Valenzuela FJ, Rojas A, Vergara M, Rojas-Garcia PP, Recabarren MP, Valenzuela GJ - PLoS ONE (2013)

Representative examples of circadian rhythms of activity (left panel) and temperature (right panel) in three pregnant capuchin monkeys.LD: females maintained in light:dark 14∶10 during pregnancy; LL: females maintained in constant light during pregnancy; LL+M: LL females receiving a daily melatonin replacement at 1800 h. The arrows indicates delivery.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585206&req=5

pone-0057710-g001: Representative examples of circadian rhythms of activity (left panel) and temperature (right panel) in three pregnant capuchin monkeys.LD: females maintained in light:dark 14∶10 during pregnancy; LL: females maintained in constant light during pregnancy; LL+M: LL females receiving a daily melatonin replacement at 1800 h. The arrows indicates delivery.
Mentions: Activity and temperature rhythms were detected in all pregnant females, before and after delivery (Figure 1). Regardless of the treatment, the day preceding delivery, and one day postpartum, some females showed decreased activity and tended to spend most of the day in a corner of the cage, usually away from the telemetry receiver, resulting in missing data points in the record. Activity resumed to values observed before delivery in the following postpartum days. Temperature increased during the first 48 h following delivery in most females although comparison of mesor before and after delivery did not reach significance. Activity and temperature rhythms were calculated from the 24-h recordings of each rhythm obtained 96 hours before delivery in order to compare animals in the same condition.

Bottom Line: In addition, mean temperature was decreased (34.0±0.6 vs 36.1±0.2°C, in LL and control, respectively P<0.05).Our findings demonstrate that prenatal melatonin is a Zeitgeber for the newborn temperature rhythm and supports normal body temperature maintenance.Altogether these prenatal melatonin effects highlight the physiological importance of the maternal melatonin rhythm during pregnancy for the newborn primate.

View Article: PubMed Central - PubMed

Affiliation: Programa de Fisiopatología, Facultad de Medicina, Universidad de Chile, Santiago, Chile. mseron@med.uchile.cl

ABSTRACT
Disruption of the maternal environment during pregnancy is a key contributor to offspring diseases that develop in adult life. To explore the impact of chronodisruption during pregnancy in primates, we exposed pregnant capuchin monkeys to constant light (eliminating the maternal melatonin rhythm) from the last third of gestation to term. Maternal temperature and activity circadian rhythms were assessed as well as the newborn temperature rhythm. Additionally we studied the effect of daily maternal melatonin replacement during pregnancy on these rhythms. Ten pregnant capuchin monkeys were exposed to constant light from 60% of gestation to term. Five received a daily oral dose of melatonin (250 µg kg/body weight) at 1800 h (LL+Mel) and the other five a placebo (LL). Six additional pregnant females were maintained in a 14∶10 light:dark cycles and their newborns were used as controls (LD). Rhythms were recorded 96 h before delivery in the mother and at 4-6 days of age in the newborn. Exposure to constant light had no effect on the maternal body temperature rhythm however it delayed the acrophase of the activity rhythm. Neither rhythm was affected by melatonin replacement. In contrast, maternal exposure to constant light affected the newborn body temperature rhythm. This rhythm was entrained in control newborns whereas LL newborns showed a random distribution of the acrophases over 24-h. In addition, mean temperature was decreased (34.0±0.6 vs 36.1±0.2°C, in LL and control, respectively P<0.05). Maternal melatonin replacement during pregnancy re-synchronized the acrophases and restored mean temperature to the values in control newborns. Our findings demonstrate that prenatal melatonin is a Zeitgeber for the newborn temperature rhythm and supports normal body temperature maintenance. Altogether these prenatal melatonin effects highlight the physiological importance of the maternal melatonin rhythm during pregnancy for the newborn primate.

Show MeSH
Related in: MedlinePlus